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Erschienen in: Breast Cancer Research and Treatment 2/2020

23.10.2019 | Review

Untapped “-omics”: the microbial metagenome, estrobolome, and their influence on the development of breast cancer and response to treatment

verfasst von: A. S. Komorowski, R. C. Pezo

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2020

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Abstract

With the advent of next generation sequencing technologies, there is an increasingly complex understanding of the role of gastrointestinal and local breast microbial dysbiosis in breast cancer. In this review, we summarize the current understanding of the microbiome’s role in breast carcinogenesis, discussing modifiable risk factors that may affect breast cancer risk by inducing dysbiosis as well as recent sequencing data illustrating breast cancer subtype-specific differences in local breast tissue microbiota. We outline how the ‘estrobolome,’ the aggregate of estrogen-metabolizing enteric bacterial genes, may affect the risk of developing postmenopausal estrogen receptor–positive breast cancer. We also discuss the microbiome’s potent capacity for anticancer therapy activation and deactivation, an important attribute of the gastrointestinal microbiome that has yet to be harnessed clinically.
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Metadaten
Titel
Untapped “-omics”: the microbial metagenome, estrobolome, and their influence on the development of breast cancer and response to treatment
verfasst von
A. S. Komorowski
R. C. Pezo
Publikationsdatum
23.10.2019
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 2/2020
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-019-05472-w

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