Skip to main content
Erschienen in: Nuclear Medicine and Molecular Imaging 3/2017

16.05.2016 | Interesting Image

Unusual Soft Tissue Uptake of F-18 Sodium Fluoride in Three Patients Undergoing F-18 NaF PET/CT Bone Scans for Prostate Cancer

verfasst von: Andrew S. Hawkins, Brandon A. Howard

Erschienen in: Nuclear Medicine and Molecular Imaging | Ausgabe 3/2017

Einloggen, um Zugang zu erhalten

Abstract

Three males aged 71 to 80 years with known stage IV metastatic prostate cancer underwent F-18 sodium fluoride (NaF) PET/CT to assess osseous metastatic disease burden and stability. In addition to F-18 NaF avid known osseous metastases, each patient also exhibited increased F-18 NaF activity in soft tissues. The first patient exhibited multiple F-18 NaF avid enlarged retroperitoneal and pelvic lymph nodes on consecutive PET/CT scans. The second patient demonstrated an F-18 NaF avid thyroid nodule on consecutive PET/CT scans. The third patient exhibited increased F-18 NaF activity in a hepatic metastasis.
Literatur
1.
Zurück zum Zitat Segall G, Delbeke D, Stabin MG, Even-Sapir E, Fair J, Sajdak R, et al. SNM practice guideline for sodium 18F-fluoride PET/CT bone scans 1.0. J Nucl Med. 2010;51:1813–20.CrossRefPubMed Segall G, Delbeke D, Stabin MG, Even-Sapir E, Fair J, Sajdak R, et al. SNM practice guideline for sodium 18F-fluoride PET/CT bone scans 1.0. J Nucl Med. 2010;51:1813–20.CrossRefPubMed
2.
Zurück zum Zitat Sabbah N, Jackson T, Mosci C, Jamali M, Minamimoto R, Quon A, et al. 18F-sodium fluoride PET/CT in oncology: an atlas of SUV’s. Clin Nucl Med. 2015;40:e228–31.CrossRefPubMed Sabbah N, Jackson T, Mosci C, Jamali M, Minamimoto R, Quon A, et al. 18F-sodium fluoride PET/CT in oncology: an atlas of SUV’s. Clin Nucl Med. 2015;40:e228–31.CrossRefPubMed
3.
Zurück zum Zitat Sheth S, Colletti PM. Atlas of sodium fluoride PET bone scans: atlas of NaF PET bone scans. Clin Nucl Med. 2012;37:e110–6.CrossRefPubMed Sheth S, Colletti PM. Atlas of sodium fluoride PET bone scans: atlas of NaF PET bone scans. Clin Nucl Med. 2012;37:e110–6.CrossRefPubMed
4.
Zurück zum Zitat Dweck MR, Chow MW, Joshi NV, Williams MC, Jones C, Fletcher AM, et al. Coronary arterial 18F-sodium fluoride uptake: a novel marker of plaque biology. J Am Coll Cardiol. 2012;59:1539–48.CrossRefPubMed Dweck MR, Chow MW, Joshi NV, Williams MC, Jones C, Fletcher AM, et al. Coronary arterial 18F-sodium fluoride uptake: a novel marker of plaque biology. J Am Coll Cardiol. 2012;59:1539–48.CrossRefPubMed
5.
Zurück zum Zitat Yoon DY, Chang SK, Choi CS, Yun EJ, Seo YL, Nam ES, et al. The prevalence and significance of incidental thyroid nodules identified on computed tomography. J Comput Assist Tomogr. 2008;32:810–5.CrossRefPubMed Yoon DY, Chang SK, Choi CS, Yun EJ, Seo YL, Nam ES, et al. The prevalence and significance of incidental thyroid nodules identified on computed tomography. J Comput Assist Tomogr. 2008;32:810–5.CrossRefPubMed
6.
Zurück zum Zitat Shie P, Cardarelli R, Sprawls K, Fulda KG, Taur A. Systematic review: prevalence of malignant incidental thyroid nodules identified on fluorine-18 fluorodeoxyglucose positron emission tomography. Nucl Med Commun. 2009;30:742–8.CrossRefPubMed Shie P, Cardarelli R, Sprawls K, Fulda KG, Taur A. Systematic review: prevalence of malignant incidental thyroid nodules identified on fluorine-18 fluorodeoxyglucose positron emission tomography. Nucl Med Commun. 2009;30:742–8.CrossRefPubMed
7.
Zurück zum Zitat Chun AR, Jo HM, Lee SH, Chun HW, Park JM, Kim KJ, et al. Risk of malignancy in thyroid incidentalomas identified by fluorodeoxyglucose-positron emission tomography. Endocrinol Metab (Seoul). 2015;30:71–7.CrossRef Chun AR, Jo HM, Lee SH, Chun HW, Park JM, Kim KJ, et al. Risk of malignancy in thyroid incidentalomas identified by fluorodeoxyglucose-positron emission tomography. Endocrinol Metab (Seoul). 2015;30:71–7.CrossRef
8.
Zurück zum Zitat Basu S, Kembhavi S. Serendipitous observation of hepatic metastases on (18)F-fluoride PET in a patient with infiltrating ductal carcinoma of breast: correlation with contrast enhanced CT. Clin Nucl Med. 2012;37:1176–8.PubMed Basu S, Kembhavi S. Serendipitous observation of hepatic metastases on (18)F-fluoride PET in a patient with infiltrating ductal carcinoma of breast: correlation with contrast enhanced CT. Clin Nucl Med. 2012;37:1176–8.PubMed
9.
Zurück zum Zitat Swietaszczyk C, Prasad V, Baum RP. Intense 18F-fluoride accumulation in liver metastases from a neuroendocrine tumor after peptide receptor radionuclide therapy. Clin Nucl Med. 2012;37:e82–3.CrossRefPubMed Swietaszczyk C, Prasad V, Baum RP. Intense 18F-fluoride accumulation in liver metastases from a neuroendocrine tumor after peptide receptor radionuclide therapy. Clin Nucl Med. 2012;37:e82–3.CrossRefPubMed
10.
Zurück zum Zitat Wong KK, Piert M. Dynamic bone imaging with 99mTc-labeled diphosphonates and 18F-NaF: mechanisms and applications. J Nucl Med. 2013;54:590–9.CrossRefPubMed Wong KK, Piert M. Dynamic bone imaging with 99mTc-labeled diphosphonates and 18F-NaF: mechanisms and applications. J Nucl Med. 2013;54:590–9.CrossRefPubMed
11.
Zurück zum Zitat Cook GJ, Fogelman I. The role of positron emission tomography in skeletal disease. Semin Nucl Med. 2001;31:50–61.CrossRefPubMed Cook GJ, Fogelman I. The role of positron emission tomography in skeletal disease. Semin Nucl Med. 2001;31:50–61.CrossRefPubMed
12.
Zurück zum Zitat Hawkins RA, Choi Y, Huang SC, Hoh CK, Dahlbom M, Schiepers C, et al. Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET. J Nucl Med. 1992;33:633–42.PubMed Hawkins RA, Choi Y, Huang SC, Hoh CK, Dahlbom M, Schiepers C, et al. Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET. J Nucl Med. 1992;33:633–42.PubMed
13.
Zurück zum Zitat Kurdziel KA, Shih JH, Apolo AB, Lindenberg L, Mena E, McKinney YY, et al. The kinetics and reproducibility of 18F-sodium fluoride for oncology using current PET camera technology. J Nucl Med. 2012;53:1175–84.CrossRefPubMedPubMedCentral Kurdziel KA, Shih JH, Apolo AB, Lindenberg L, Mena E, McKinney YY, et al. The kinetics and reproducibility of 18F-sodium fluoride for oncology using current PET camera technology. J Nucl Med. 2012;53:1175–84.CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Valdes-Martinez A, Kraft SL, Brundage CM, Arceneaux BK, Stewart JA, Gibbons DS. Assessment of blood pool, soft tissue, and skeletal uptake of sodium fluoride F 18 with positron emission tomography-computed tomography in four clinically normal dogs. Am J Vet Res. 2012;73:1589–95.CrossRefPubMed Valdes-Martinez A, Kraft SL, Brundage CM, Arceneaux BK, Stewart JA, Gibbons DS. Assessment of blood pool, soft tissue, and skeletal uptake of sodium fluoride F 18 with positron emission tomography-computed tomography in four clinically normal dogs. Am J Vet Res. 2012;73:1589–95.CrossRefPubMed
Metadaten
Titel
Unusual Soft Tissue Uptake of F-18 Sodium Fluoride in Three Patients Undergoing F-18 NaF PET/CT Bone Scans for Prostate Cancer
verfasst von
Andrew S. Hawkins
Brandon A. Howard
Publikationsdatum
16.05.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Nuclear Medicine and Molecular Imaging / Ausgabe 3/2017
Print ISSN: 1869-3474
Elektronische ISSN: 1869-3482
DOI
https://doi.org/10.1007/s13139-016-0420-2

Weitere Artikel der Ausgabe 3/2017

Nuclear Medicine and Molecular Imaging 3/2017 Zur Ausgabe