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Erschienen in: Clinical & Experimental Metastasis 5-6/2018

17.07.2018 | Research Paper

Update on systemic therapy for advanced cutaneous melanoma and recent development of novel drugs

verfasst von: Thein Swe, Kevin B. Kim

Erschienen in: Clinical & Experimental Metastasis | Ausgabe 5-6/2018

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Abstract

Malignant melanoma is generally chemo- and radio-resistant, and patients with advanced melanoma have a poor prognosis. However, with our increased understanding of the checkpoint immune molecules and genetic alterations of melanoma cells, more effective immunotherapy, such as anti CTLA4 antibody and anti PD-1 antibodies, and targeted drug therapy, such as BRAF inhibitors and MEK inhibitors, have been developed, resulting in improved overall survival and quality of life of patients with advanced melanoma. In addition, emerging technologies to develop prognostic and predictive biomarkers for response to systemic therapy could help clinicians make more accurate assessments of the disease and formulate more effective treatment plans. In this review, current standard systemic therapy options and recently developed novel drugs for advanced melanoma are discussed.
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Metadaten
Titel
Update on systemic therapy for advanced cutaneous melanoma and recent development of novel drugs
verfasst von
Thein Swe
Kevin B. Kim
Publikationsdatum
17.07.2018
Verlag
Springer Netherlands
Erschienen in
Clinical & Experimental Metastasis / Ausgabe 5-6/2018
Print ISSN: 0262-0898
Elektronische ISSN: 1573-7276
DOI
https://doi.org/10.1007/s10585-018-9913-y

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