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Erschienen in: Journal of Nephrology 5/2017

01.10.2017 | Review

Update on the role of bone biopsy in the management of patients with CKD–MBD

verfasst von: P. Evenepoel, G. J. S. Behets, M. R. Laurent, P. C. D’Haese

Erschienen in: Journal of Nephrology | Ausgabe 5/2017

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Abstract

Patients with chronic kidney disease (CKD) are at increased risk of fractures. The fracture risk steadily increases along with the progression of renal disease to become several-fold higher in end-stage renal disease (ESRD) patients as compared to age and sex-matched controls. Renal osteodystrophy (ROD) is a heterogeneous group of metabolic bone diseases complicating progressive chronic kidney disease. Bone biomarkers and bone imaging techniques may help to assess bone health and predict fractures in CKD, but do have important inherent limitations. The gold standard for the diagnosis and specific classification of renal osteodystrophy (ROD) remains the (quantitative) histomorphometric analysis of the bone biopsy. By informing on bone turnover and mineralization, a bone biopsy may help guide prevention and treatment of ROD and its consequences. This review aims to present an update on epidemiological and procedural aspects, clinical indications, and histomorphometric analysis of bone biopsies and to define the role of bone biopsy in current CKD–MBD care.
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Metadaten
Titel
Update on the role of bone biopsy in the management of patients with CKD–MBD
verfasst von
P. Evenepoel
G. J. S. Behets
M. R. Laurent
P. C. D’Haese
Publikationsdatum
01.10.2017
Verlag
Springer International Publishing
Erschienen in
Journal of Nephrology / Ausgabe 5/2017
Print ISSN: 1121-8428
Elektronische ISSN: 1724-6059
DOI
https://doi.org/10.1007/s40620-017-0424-8

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