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Current Fungal Infection Reports
Erschienen in: Current Fungal Infection Reports 2/2019

02.05.2019 | Pharmacology and Pharmacodynamics of Antifungal Agents (N Beyda, Section Editor)

Updates in Ocular Antifungal Pharmacotherapy: Formulation and Clinical Perspectives

verfasst von: Ruchi Thakkar, Akash Patil, Tabish Mehraj, Narendar Dudhipala, Soumyajit Majumdar

Erschienen in: Current Fungal Infection Reports | Ausgabe 2/2019

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Abstract

Purpose of Review

In this review, a compilation on the current antifungal pharmacotherapy is discussed, with emphases on the updates in the formulation and clinical approaches of the routinely used antifungal drugs in ocular therapy.

Recent Findings

Natamycin (Natacyn® eye drops) remains the only approved medication in the management of ocular fungal infections. This monotherapy shows therapeutic outcomes in superficial ocular fungal infections, but in case of deep-seated mycoses or endophthalmitis, successful therapeutic outcomes are infrequent, as a result of which alternative therapies are sought. In such cases, amphotericin B, azoles, and echinocandins are used off-label, either in combination with natamycin or with each other (frequently) or as standalone monotherapies, and have provided effective therapeutic outcomes.

Summary

In recent times, amphotericin B, azoles, and echinocandins have come to occupy an important niche in ocular antifungal pharmacotherapy, along with natamycin (still the preferred choice in most clinical cases), in the management of ocular fungal infections.
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Metadaten
Titel
Updates in Ocular Antifungal Pharmacotherapy: Formulation and Clinical Perspectives
verfasst von
Ruchi Thakkar
Akash Patil
Tabish Mehraj
Narendar Dudhipala
Soumyajit Majumdar
Publikationsdatum
02.05.2019
Verlag
Springer US
Erschienen in
Current Fungal Infection Reports / Ausgabe 2/2019
Print ISSN: 1936-3761
Elektronische ISSN: 1936-377X
DOI
https://doi.org/10.1007/s12281-019-00338-6

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