Upper respiratory symptoms remain the most common illness in athletes. Upper respiratory symptoms during heavy training and competition may impair performance. Preventing illness is the primary reason for the use of supplements, such as probiotics and prebiotics, for maintaining or promoting gut health and immune function. While exercise-induced perturbations in the immune system may increase susceptibility to illness and infection, growing evidence indicates that upper respiratory symptoms are related to a breakdown in the homeostatic regulation of the mucosal immune system of the airways. Balancing protection of the respiratory tract with normal physiological functioning requires dynamic orchestration between a wide array of immune parameters. The intestinal microbiota regulates extra-intestinal immunity via the common mucosal immune system and new evidence implicates the microbiota of the nose, mouth and respiratory tract in upper respiratory symptoms. Omics’ approaches now facilitate comprehensive profiling at the molecular and proteomic levels to reveal new pathways and molecules of immune regulation. New targets may provide for personalised nutritional and training interventions to maintain athlete health.
Mossad SB. Upper respiratory tract infections. Cleveland (OH): Cleveland Clinic, Department of Infectious Disease; 2011.
Drew M, Vlahovich N, Hughes D, et al. Prevalence of illness, poor mental health and sleep quality and low energy availability prior to the 2016 Summer Olympic Games. Br J Sports Med. 2017. https://doi.org/10.1136/bjsports-2017-098208 ( Epub ahead of print).
Nieman DC, Johanssen LM, Lee JW. Infectious episodes in runners before and after a roadrace. J Sports Med Phys Fit. 1989;29:289–96.
Nieman DC, Johanssen LM, Lee JW, et al. Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fit. 1990;30:316–28.
Bonsignore MR, Morici G, Riccobono L, et al. Airway inflammation in nonasthmatic amateur runners. Am J Physiol. 2001;281:L668–76.
Bonini M, Palange P. Exercise-induced bronchoconstriction: new evidence in pathogenesis, diagnosis and treatment. Asthma Res Pract. 2015;1:1. CrossRef
Smith LL. Overtraining, excessive exercise, and altered immunity. Sports Med. 2003;33:347–64. CrossRef
Walsh NP, Gleeson M, Shephard RJ, et al. Position statement. Part one: immune function and exercise. Exerc Immunol Rev. 2011;17:6–63. PubMed
Simpson RJ, Kunz H, Agha N, et al. Exercise and the regulation of immune functions. Progr Mol Biol Transl Sci. 2015;135:355–80. CrossRef
Sznurkowska K, Żawrocki A, Sznurkowski J, et al. Peripheral and intestinal T-regulatory cells are upregulated in children with inflammatory bowel disease at onset of disease. Immunol Invest. 2016;45:787–96. CrossRef
Moldaver DM, Larché M, Rudulier CD. An update on lymphocyte subtypes in asthma and airway disease. Chest J. 2016;151:1122–30. CrossRef
Cox AJ, West NP, Cripps AW. Obesity, inflammation, and the gut microbiota. Lancet Diab Endocrinol. 2015;3:207–15. CrossRef
Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486:207–14. CrossRef
Kang W, Kudsk KA. Is there evidence that the gut contributes to mucosal immunity in humans? J Parenter Enteral Nutr. 2007;31:246–58. CrossRef
Okumura R, Takeda K. Maintenance of gut homeostasis by the mucosal immune system. Proc Jpn Acad Ser B. 2016;92:423–35. CrossRef
Tims S. Mining microbiota signatures in human intestinal tract metagenomes. Wageningen: Wageningen University; 2016.
Bermon S, Petriz B, Kajeniene A, et al. The microbiota: an exercise immunology perspective. Exerc Immunol Rev. 2015;21:70–9. PubMed
West NP, Pyne DB, Peake JM, et al. Probiotics, immunity and exercise: a review. Exerc Immunol Rev. 2009;15:107–26. PubMed
West NP, Pyne DB, Cripps AW, et al. Lactobacillus fermentum (PCC ®) supplementation and gastrointestinal and respiratory-tract illness symptoms: a randomised control trial in athletes. Nutr J. 2011;10:1. CrossRef
West NP, Christophersen CT, Pyne DB, et al. Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals. Exerc Immunol Rev. 2013;19:102–19. PubMed
Jones AW, March DS, Curtis F, et al. Bovine colostrum supplementation and upper respiratory symptoms during exercise training: a systematic review and meta-analysis of randomised controlled trials. BMC Sports Sci Med Rehab. 2016;8:21. CrossRef
Grassl N, Kulak NA, Pichler G, et al. Ultra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome. Genome Med. 2016;8:1. CrossRef
Horgan RP, Kenny LC. ‘Omic’ technologies: genomics, transcriptomics, proteomics and metabolomics. Obstet Gynaecol. 2011;13:189–95.
Baumgart S, Peddinghaus A, Schulte-Wrede U, et al. OMIP-034: comprehensive immune phenotyping of human peripheral leukocytes by mass cytometry for monitoring immunomodulatory therapies. Cytom Part A. 2017;91:25–33. CrossRef
Cox A, Zhang P, Bowden D, et al. Increased intestinal permeability as a risk factor for type 2 diabetes. Diab Metab. 2017;43:163–6. CrossRef
Wallden B, Storhoff J, Nielsen T, et al. Development and verification of the PAM50-based Prosigna breast cancer gene signature assay. BMC Med Genom. 2015;8:1. CrossRef
Macdonald L, Bellinger P, Minahan C. Reliability of salivary cortisol and immunoglobulin-A measurements from the IPRO ® before and after sprint cycling exercise. J Sports Med Phys Fit. 2017;57(12):1680–6.
- Upper Respiratory Symptoms, Gut Health and Mucosal Immunity in Athletes
Amanda J. Cox
David B. Pyne
Allan W. Cripps
Nicholas P. West
- Springer International Publishing
Neu im Fachgebiet Orthopädie und Unfallchirurgie
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