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Erschienen in: International Urology and Nephrology 8/2016

18.05.2016 | Urology - Original Paper

Upper urinary tract urothelial carcinoma behaviors in patients with end-stage renal disease after kidney transplantation in Taiwan

verfasst von: Chia-Shen Chien, Hao Lun Luo, Chou Shu Ling, Po-Hui Chiang, Yen-Ta Chen, Yuan Tso Cheng

Erschienen in: International Urology and Nephrology | Ausgabe 8/2016

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Abstract

Purpose

To determine upper urinary tract urothelial carcinoma (UT-UC) behavior in patients with end-stage renal disease (ESRD) after kidney transplantation (KT).

Methods

From 2005 to 2012, 117 ESRD patients with localized UT-UC underwent nephroureterectomy at our institution. We divide these patients into two groups according to having had KT or not. Kaplan–Meier survival plot and multivariate analysis were used to evaluate whether kidney transplantation interfered with the UT-UC outcome.

Results

The mean age was younger in ESRD with KT group (p = 0.001), but there was no difference in gender, smoking, or previous bladder cancer history between these two groups. The pathological features were more aggressive in ESRD with KT group compared to those without KT in regard to incidence of carcinoma in situ (p = 0.025) and multifocality (p = 0.001). Kidney transplantation did not interfere with the oncological outcome of UT-UC in ESRD patients. There were no differences in oncological outcome. Five-year metastasis-free survival rate was comparable.

Conclusion

In our sample, for patients with ESRD after kidney transplantation, the postoperative onset of UT-UC was younger and the pathological features were more aggressive. Standard surgical intervention resulted in satisfactory and similar outcome as did ESRD.
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Metadaten
Titel
Upper urinary tract urothelial carcinoma behaviors in patients with end-stage renal disease after kidney transplantation in Taiwan
verfasst von
Chia-Shen Chien
Hao Lun Luo
Chou Shu Ling
Po-Hui Chiang
Yen-Ta Chen
Yuan Tso Cheng
Publikationsdatum
18.05.2016
Verlag
Springer Netherlands
Erschienen in
International Urology and Nephrology / Ausgabe 8/2016
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-016-1308-x

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