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Erschienen in: Clinical Journal of Gastroenterology 4/2017

26.04.2017 | Case Report

Uptake of 123I-metaiodobenzylguanidine by gastrointestinal stromal tumor

verfasst von: Patommatat Bhanthumkomol, Susumu Hijioka, Nobumasa Mizuno, Takamichi Kuwahara, Nozomi Okuno, Ayako Ito, Tsutomu Tanaka, Makoto Ishihara, Yutaka Hirayama, Sachiyo Onishi, Yasumasa Niwa, Masahiro Tajika, Yuichi Ito, Eiichi Sasaki, Yoshitaka Inaba, Yasuhiro Shimizu, Yasushi Yatabe, Kazuo Hara

Erschienen in: Clinical Journal of Gastroenterology | Ausgabe 4/2017

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Abstract

A 52-year-old woman was admitted with a large intraabdominal mass. 123I- metaiodobenzylguanidine (123I-MIBG) scintigraphy revealed considerable 123I-MIBG accumulation by the mass that was compatible with a diagnosis of paraganglioma. However, a spindle cell tumor that was identified using endoscopic ultrasound-guided fine needle aspiration before surgery was positive for CD117. The surgically resected mass was confirmed as a gastrointestinal stromal tumor (GIST). Although the mechanism of 123I-MIBG uptake by GIST has not been elucidated, GIST should be included in the differential diagnosis of intra-abdominal tumor with 123I-MIBG uptake.
Literatur
1.
Zurück zum Zitat Shapiro B. Summary, conclusions, and future directions of [131I]metaiodobenzylguanidine therapy in the treatment of neural crest tumors. J Nucl Biol Med. 1991;35(4):357–63.PubMed Shapiro B. Summary, conclusions, and future directions of [131I]metaiodobenzylguanidine therapy in the treatment of neural crest tumors. J Nucl Biol Med. 1991;35(4):357–63.PubMed
2.
Zurück zum Zitat Ilias I, Pacak K. Current approaches and recommended algorithm for the diagnostic localization of pheochromocytoma. J Clin Endocrinol Metab. 2004;89(2):479–91.CrossRefPubMed Ilias I, Pacak K. Current approaches and recommended algorithm for the diagnostic localization of pheochromocytoma. J Clin Endocrinol Metab. 2004;89(2):479–91.CrossRefPubMed
3.
Zurück zum Zitat Sone H, Okuda Y, Nakamura Y, et al. Radioiodinated metaiodobenzylguanidine scintigraphy for pheochromocytoma. A false-positive case of adrenocortical adenoma and literature review. Horm Res. 1996;46:138–42.CrossRefPubMed Sone H, Okuda Y, Nakamura Y, et al. Radioiodinated metaiodobenzylguanidine scintigraphy for pheochromocytoma. A false-positive case of adrenocortical adenoma and literature review. Horm Res. 1996;46:138–42.CrossRefPubMed
4.
Zurück zum Zitat Rainis T, Ben-Haim S, Dickstein G. False positive metaiodobenzylguanidine scan in a patient with a huge adrenocortical carcinoma. J Clin Endocrinol Metab. 2000;85:5–7.CrossRefPubMed Rainis T, Ben-Haim S, Dickstein G. False positive metaiodobenzylguanidine scan in a patient with a huge adrenocortical carcinoma. J Clin Endocrinol Metab. 2000;85:5–7.CrossRefPubMed
5.
Zurück zum Zitat Jung HS, Moon SJ, Kim YM, et al. False positive radioiodinated metaiodobenzylguanidine ((123)I-MIBG) uptake in undifferentiated adrenal malignant tumor. Case Rep Oncol Med. 2015;2015:164280.PubMedPubMedCentral Jung HS, Moon SJ, Kim YM, et al. False positive radioiodinated metaiodobenzylguanidine ((123)I-MIBG) uptake in undifferentiated adrenal malignant tumor. Case Rep Oncol Med. 2015;2015:164280.PubMedPubMedCentral
6.
Zurück zum Zitat Inoue Y, Akahane M, Kitazawa T, et al. False positive uptake of metaiodobenzylguanidine in hepatocellular carcinoma. Br J Radiol. 2002;75:548–51.CrossRefPubMed Inoue Y, Akahane M, Kitazawa T, et al. False positive uptake of metaiodobenzylguanidine in hepatocellular carcinoma. Br J Radiol. 2002;75:548–51.CrossRefPubMed
7.
Zurück zum Zitat Kume H, Nishimura S, Teramoto S, et al. An [123 I]MIBG-positive malignant lymphoma involving the adrenal gland with hypercatecholaminaemia. Clin Radiol. 2008;6:475–7.CrossRef Kume H, Nishimura S, Teramoto S, et al. An [123 I]MIBG-positive malignant lymphoma involving the adrenal gland with hypercatecholaminaemia. Clin Radiol. 2008;6:475–7.CrossRef
8.
Zurück zum Zitat Rottenburger C, Juettner E, Harttrampf AC, et al. False-positive radio-iodinated metaiodobenzylguanidine (123I-MIBG) accumulation in a mast cell-infiltrated infantile haemangioma. Br J Radiol. 2010;83:e168–71.CrossRefPubMedPubMedCentral Rottenburger C, Juettner E, Harttrampf AC, et al. False-positive radio-iodinated metaiodobenzylguanidine (123I-MIBG) accumulation in a mast cell-infiltrated infantile haemangioma. Br J Radiol. 2010;83:e168–71.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Kubota K, Kato S, Mawatari H, et al. Risky endoscopic ultrasonography-guided fine-needle aspiration for asymptomatic retroperitoneal tumors. Dig Endosc. 2010;22:144–6.CrossRefPubMed Kubota K, Kato S, Mawatari H, et al. Risky endoscopic ultrasonography-guided fine-needle aspiration for asymptomatic retroperitoneal tumors. Dig Endosc. 2010;22:144–6.CrossRefPubMed
10.
Zurück zum Zitat Demetri GD, von Mehren M, Antonescu CR, et al. NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors. J Natl Compr Canc Netw. 2010;8(Suppl 2):S1–41.CrossRefPubMedPubMedCentral Demetri GD, von Mehren M, Antonescu CR, et al. NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors. J Natl Compr Canc Netw. 2010;8(Suppl 2):S1–41.CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Jacobson AF, Deng H, Lombard J, et al. 123I-meta-iodobenzylguanidine scintigraphy for the detection of neuroblastoma and pheochromocytoma: results of a meta-analysis. J Clin Endocrinol Metab. 2010;95:2596–606.CrossRefPubMed Jacobson AF, Deng H, Lombard J, et al. 123I-meta-iodobenzylguanidine scintigraphy for the detection of neuroblastoma and pheochromocytoma: results of a meta-analysis. J Clin Endocrinol Metab. 2010;95:2596–606.CrossRefPubMed
12.
Zurück zum Zitat Kindblom LG, Remotti HE, Aldenborg F, et al. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol. 1998;152:1259–69.PubMedPubMedCentral Kindblom LG, Remotti HE, Aldenborg F, et al. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol. 1998;152:1259–69.PubMedPubMedCentral
13.
Zurück zum Zitat Sircar K, Hewlett BR, Huizinga JD, et al. Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am J Surg Pathol. 1999;23:377–89.CrossRefPubMed Sircar K, Hewlett BR, Huizinga JD, et al. Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors. Am J Surg Pathol. 1999;23:377–89.CrossRefPubMed
14.
Zurück zum Zitat Terada T. Smooth muscles and stem cells of embryonic guts express KIT, PDGFRA, CD34 and many other stem cell antigens: Suggestion that GIST arise from smooth muscles and gut stem cells. Int J Clin Exp Pathol. 2013;6:1038–45.PubMedPubMedCentral Terada T. Smooth muscles and stem cells of embryonic guts express KIT, PDGFRA, CD34 and many other stem cell antigens: Suggestion that GIST arise from smooth muscles and gut stem cells. Int J Clin Exp Pathol. 2013;6:1038–45.PubMedPubMedCentral
15.
Zurück zum Zitat Balan KK, Sonoda LI, Pawaroo D. I-123 MIBG uptake in a gastrointestinal stromal tumor (GIST). Clin Nucl Med. 2010;35:196–7.CrossRefPubMed Balan KK, Sonoda LI, Pawaroo D. I-123 MIBG uptake in a gastrointestinal stromal tumor (GIST). Clin Nucl Med. 2010;35:196–7.CrossRefPubMed
16.
Zurück zum Zitat Fukuchi K, Suzuki M, Sato S, et al. Unusually increased metaiodobenzylguanidine uptake in a gastrointestinal stromal tumor of the stomach. Ann Nucl Med. 2012;26:684–7.CrossRefPubMed Fukuchi K, Suzuki M, Sato S, et al. Unusually increased metaiodobenzylguanidine uptake in a gastrointestinal stromal tumor of the stomach. Ann Nucl Med. 2012;26:684–7.CrossRefPubMed
17.
Zurück zum Zitat van Dellen D, Mitu-Pretorian OM, Augustine T. Aberrant I-123 MIBG uptake in a gastrointestinal stromal tumour. Updat Surg. 2013;65:71–6.CrossRef van Dellen D, Mitu-Pretorian OM, Augustine T. Aberrant I-123 MIBG uptake in a gastrointestinal stromal tumour. Updat Surg. 2013;65:71–6.CrossRef
18.
Zurück zum Zitat Harb A, Forster J, Damjanov I. Gastrointestinal autonomic nerve tumor secreting catecholamines. Virchows Arch. 2005;447:892–3.CrossRefPubMed Harb A, Forster J, Damjanov I. Gastrointestinal autonomic nerve tumor secreting catecholamines. Virchows Arch. 2005;447:892–3.CrossRefPubMed
19.
Zurück zum Zitat Meshikhes AW, Al-Momen SA. Gastrointestinal autonomic nerve tumors: a clinical review. J Gastrointest Surg. 2015;19:1144–56.CrossRefPubMed Meshikhes AW, Al-Momen SA. Gastrointestinal autonomic nerve tumors: a clinical review. J Gastrointest Surg. 2015;19:1144–56.CrossRefPubMed
20.
Zurück zum Zitat Bayer M, Kuci Z, Schomig E, Grundemann D, Dittmann H, Handgretinger R, et al. Uptake of mIBG and catecholamines in noradrenaline- and organic cation transporter expressing cells: potential use of corticosterone for a preferred uptake in neuroblastoma- and pheochromocytoma cells. Nucl Med Biol. 2009;36:287–94.CrossRefPubMed Bayer M, Kuci Z, Schomig E, Grundemann D, Dittmann H, Handgretinger R, et al. Uptake of mIBG and catecholamines in noradrenaline- and organic cation transporter expressing cells: potential use of corticosterone for a preferred uptake in neuroblastoma- and pheochromocytoma cells. Nucl Med Biol. 2009;36:287–94.CrossRefPubMed
Metadaten
Titel
Uptake of 123I-metaiodobenzylguanidine by gastrointestinal stromal tumor
verfasst von
Patommatat Bhanthumkomol
Susumu Hijioka
Nobumasa Mizuno
Takamichi Kuwahara
Nozomi Okuno
Ayako Ito
Tsutomu Tanaka
Makoto Ishihara
Yutaka Hirayama
Sachiyo Onishi
Yasumasa Niwa
Masahiro Tajika
Yuichi Ito
Eiichi Sasaki
Yoshitaka Inaba
Yasuhiro Shimizu
Yasushi Yatabe
Kazuo Hara
Publikationsdatum
26.04.2017
Verlag
Springer Japan
Erschienen in
Clinical Journal of Gastroenterology / Ausgabe 4/2017
Print ISSN: 1865-7257
Elektronische ISSN: 1865-7265
DOI
https://doi.org/10.1007/s12328-017-0743-2

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