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01.12.2011 | Research | Ausgabe 1/2011 Open Access

Journal of the International AIDS Society 1/2011

Uptake of prevention of mother to child transmission interventions in Kenya: health systems are more influential than stigma

Zeitschrift:
Journal of the International AIDS Society > Ausgabe 1/2011
Autoren:
John Kinuthia, James N Kiarie, Carey Farquhar, Barbra A Richardson, Ruth Nduati, Dorothy Mbori-Ngacha, Grace John-Stewart
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

JK undertook conception and design of the study, data acquisition, analysis, interpretation and drafting of the manuscript. JNK assisted with study design, implementation, analysis and manuscript drafting. CF assisted with data interpretation and manuscript drafting. BR assisted with statistical analyses and manuscript writing. RN assisted with study design, data interpretation and manuscript drafting. DMN assisted with study design and data interpretation. GJS provided primary mentorship of JK, oversight of study conception and design, data analysis, manuscript writing and obtained grant funding. All authors read and approved the final manuscript.

Abstract

Background

We set out to determine the relative roles of stigma versus health systems in non-uptake of prevention of mother to child transmission (PMTCT) of HIV-1 interventions: we conducted cross-sectional assessment of all consenting mothers accompanying infants for six-week immunizations.

Methods

Between September 2008 and March 2009, mothers at six maternal and child health clinics in Kenya's Nairobi and Nyanza provinces were interviewed regarding PMTCT intervention uptake during recent pregnancy. Stigma was ascertained using a previously published standardized questionnaire and infant HIV-1 status determined by HIV-1 polymerase chain reaction.

Results

Among 2663 mothers, 2453 (92.1%) reported antenatal HIV-1 testing. Untested mothers were more likely to have less than secondary education (85.2% vs. 74.9%, p = 0.001), be from Nyanza (47.1% vs. 32.2%, p < 0.001) and have lower socio-economic status. Among 318 HIV-1-infected mothers, 90% reported use of maternal or infant antiretrovirals. Facility delivery was less common among HIV-1-infected mothers (69% vs. 76%, p = 0.009) and was associated with antiretroviral use (p < 0.001). Although internal or external stigma indicators were reported by between 12% and 59% of women, stigma was not associated with lower HIV-1 testing or infant HIV-1 infection rates; internal stigma was associated with modestly decreased antiretroviral uptake. Health system factors contributed to about 60% of non-testing among mothers who attended antenatal clinics and to missed opportunities in offering antiretrovirals and utilization of facility delivery. Eight percent of six-week-old HIV-1-exposed infants were HIV-1 infected.

Conclusions

Antenatal HIV-1 testing and antiretroviral uptake was high (both more than 90%) and infant HIV-1 infection risk was low, reflecting high PMTCT coverage. Investment in health systems to deliver HIV-1 testing and antiretrovirals can effectively prevent infant HIV-1 infection despite substantial HIV-1 stigma.
Literatur
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