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01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Orphanet Journal of Rare Diseases 1/2017

Urinary glutamine/glutamate ratio as a potential biomarker of pediatric chronic intestinal pseudo-obstruction

Orphanet Journal of Rare Diseases > Ausgabe 1/2017
Jun-Kai Yan, Ke-Jun Zhou, Jian-Hu Huang, Qing-Qing Wu, Tian Zhang, Chao-Chen Wang, Wei Cai
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Electronic supplementary material

The online version of this article (doi:10.​1186/​s13023-017-0615-3) contains supplementary material, which is available to authorized users.


Chronic intestinal pseudo-obstruction (CIPO) is a rare intestinal motility disorder with significant morbidity and mortality in pediatric patients. The diagnosis of CIPO is difficult, because it is clinically based on the symptoms and signs of bowel obstruction which are similar to the clinical manifestations of other gastrointestinal diseases like short bowel syndrome (SBS). Therefore, it is desirable to identify and establish new laboratory diagnostic markers for CIPO that are reliable and easily accessible. In our study we have identified the ratio of the urinary glutamine and glutamic acid as a promising biomarker for distinguishing suspected CIPO cases and simple SBS cases. The area under ROC curve was 0.83, at cutoff value = 7.04 with sensitivity of 65% and specificity of 92%.
Additional file 1: Absolute concentrations of Gln and Glu, as well as Gln/Glu ratios in 3 representative patients. (DOCX 214 kb)
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