Urinary metabolomics analysis of patients with renal tubular dysfunction after PCI surgery

Compared with the control group, α1-MG, NAG and Cys-C in the urine of the observation group were significantly increased, and the difference was statistically significant (P < 0.05). After the urine samples were processed by LC–MS technology, SIMCA realized the visual visualization of the score plots of PCA, OPLS-DA and other models, and then verified by statistical methods, it was found that there were different metabolites in the urine of patients before and after PCI. The HMDB database was used to search for differential metabolites and 16 different metabolites such as L-ornithine, oleic acid amide, D-histidine, p-hydroxyphenyllactic acid, acetylmethionine, N-(2-furanyl) glycine, cholesterol laurate, cholic acid, 1-methylguanine, L-hydrochloric acid, homovanillic acid, alpha-keto-isocaproic acid, 3-β-hydroxy-D5-cholenoic acid, adenine, palmitic acid, pentadecanoic acid. Pathway Analysis in MetaboAnalyst5.0 was used to analyze the metabolic pathways of 16 different metabolites. Finally, a total of 11 metabolic pathways were matched. Finally, we believe that the biosynthetic pathway of arginine and the metabolic pathway of alanine, aspartate and glutamate are most relevant to tubular dysfunction after percutaneous coronary intervention (PCI).