Skip to main content
Erschienen in: International Urogynecology Journal 9/2020

31.10.2019 | Original Article

Urinary tract infection after clean-contaminated pelvic surgery: a retrospective cohort study and prediction model

verfasst von: May Sara Sanaee, Kathy Pan, Terry Lee, Nicole A. Koenig, Roxana Geoffrion

Erschienen in: International Urogynecology Journal | Ausgabe 9/2020

Einloggen, um Zugang zu erhalten

Abstract

Introduction and hypothesis

Postoperative urinary tract infection (UTI) leads to increased patient morbidity and health care costs. A prediction model may identify patients at highest risk for UTI development. Our primary objective was to determine the rate of UTI in the first 6 weeks after benign gynecologic surgery. Our secondary objective was to identify risk factors and build a predictive model for postoperative UTI.

Methods

We reviewed 310 patient records, which represent all patients who underwent clean-contaminated surgery at a tertiary center (2016–2017). UTI was defined as positive urine culture (> 100,000,000 CFU/l) in a symptomatic patient. Pre-, intra- and postoperative variables were collected. The relation between these variables and UTI was assessed through logistic regression. A clinical prediction model was built.

Results

Patients’ mean age was 58.5 years and mean body mass index was 27.5 kg/m2. Most were inpatients (65.8%) and 269 had urogynecologic procedures, with the remainder undergoing pelvic surgery for other indications. The most common operation was vaginal reconstruction for prolapse (59.7%), associated with concomitant synthetic midurethral sling in 1/3 cases. Forty patients (12.9%) developed UTI. Multivariate prediction modeling showed increasing age (OR 1.33, CI 1.01–1.75), increasing number of procedures (OR 1.42, CI 1.14–1.78) and prolonged voiding dysfunction (OR 3.78, CI 1.66–8.60) to be significant UTI predictors.

Conclusions

Urinary tract infection in the first 6 weeks after complex pelvic surgery is common. Our prediction model identifies that patients who are older women, have prolonged voiding dysfunction and have a greater number of concomitant pelvic floor surgeries have higher risk of postoperative UTI.
Literatur
1.
Zurück zum Zitat Wu JM, Matthews CA, Conover MM, et al. Lifetime risk of stress urinary incontinence or pelvic organ prolapse surgery. Obstet Gynecol. 2014;123:1201.CrossRef Wu JM, Matthews CA, Conover MM, et al. Lifetime risk of stress urinary incontinence or pelvic organ prolapse surgery. Obstet Gynecol. 2014;123:1201.CrossRef
2.
Zurück zum Zitat Keshavarz H, Hillis SD, Kieke BA, et al. Hysterectomy surveillance–United States, 1994–1999. MMWR CDC Surveill Summ. 2002;51:SS–5. Keshavarz H, Hillis SD, Kieke BA, et al. Hysterectomy surveillance–United States, 1994–1999. MMWR CDC Surveill Summ. 2002;51:SS–5.
3.
Zurück zum Zitat de Lissovoy G, Fraeman K, Hutchins V, et al. Surgical site infection: incidence and impact on hospital utilization and treatment costs. Am J Infect Control. 2009;37:387.CrossRef de Lissovoy G, Fraeman K, Hutchins V, et al. Surgical site infection: incidence and impact on hospital utilization and treatment costs. Am J Infect Control. 2009;37:387.CrossRef
4.
Zurück zum Zitat Lachiewicz MP, Moulton LJ, Jaiyeoba O. Pelvic surgical site infections in gynecologic surgery. Infect Dis Obstet Gynecol. 2015;2015:614950.CrossRef Lachiewicz MP, Moulton LJ, Jaiyeoba O. Pelvic surgical site infections in gynecologic surgery. Infect Dis Obstet Gynecol. 2015;2015:614950.CrossRef
5.
Zurück zum Zitat Ayeleke RO, Mourad S, Marjoribanks J, Calis KA, Jordan V. Antibiotic prophylaxis for elective hysterectomy. Cochrane Database Syst Rev. 2017;6:CD004637.PubMed Ayeleke RO, Mourad S, Marjoribanks J, Calis KA, Jordan V. Antibiotic prophylaxis for elective hysterectomy. Cochrane Database Syst Rev. 2017;6:CD004637.PubMed
6.
Zurück zum Zitat Lake AG, McPencow AM, Dick-Biascoechea MA, et al. Surgical site infection after hysterectomy. Am J Obstet Gynecol. 2013;209:e1.CrossRef Lake AG, McPencow AM, Dick-Biascoechea MA, et al. Surgical site infection after hysterectomy. Am J Obstet Gynecol. 2013;209:e1.CrossRef
7.
Zurück zum Zitat Bolling DR, Plunkett GD. Prophylactic antibiotics for vaginal hysterectomies. Obstet Gynecol. 1973;41:3. Bolling DR, Plunkett GD. Prophylactic antibiotics for vaginal hysterectomies. Obstet Gynecol. 1973;41:3.
8.
Zurück zum Zitat Vij SC, Kartha G, Krishnamurthi V, et al. Simple operating room bundle reduces superficial surgical site infections after major urologic surgery. Urology. 2017;112:66.CrossRef Vij SC, Kartha G, Krishnamurthi V, et al. Simple operating room bundle reduces superficial surgical site infections after major urologic surgery. Urology. 2017;112:66.CrossRef
9.
Zurück zum Zitat Zywot A, Lau CSM, Fletcher HS, et al. Bundles prevent surgical site infections after colorectal surgery: meta-analysis and systematic review. J Gastrointest Surg. 2017;21:1915.CrossRef Zywot A, Lau CSM, Fletcher HS, et al. Bundles prevent surgical site infections after colorectal surgery: meta-analysis and systematic review. J Gastrointest Surg. 2017;21:1915.CrossRef
10.
Zurück zum Zitat Harris JA, Sammarco AG, Swenson CW, et al. Are perioperative bundles associated with reduced postoperative morbidity in women undergoing benign hysterectomy? Retrospective cohort analysis of 16,286 cases in Michigan. Am J Obstet Gynecol. 2017;216:e1.CrossRef Harris JA, Sammarco AG, Swenson CW, et al. Are perioperative bundles associated with reduced postoperative morbidity in women undergoing benign hysterectomy? Retrospective cohort analysis of 16,286 cases in Michigan. Am J Obstet Gynecol. 2017;216:e1.CrossRef
11.
Zurück zum Zitat Taylor JS, Marten CA, Munsell MF, et al. The DISINFECT initiative: decreasing the incidence of surgical INFECTions in gynecologic oncology. Ann Surg Oncol. 2017;24:362.CrossRef Taylor JS, Marten CA, Munsell MF, et al. The DISINFECT initiative: decreasing the incidence of surgical INFECTions in gynecologic oncology. Ann Surg Oncol. 2017;24:362.CrossRef
12.
Zurück zum Zitat Martin EK, Beckmann MM, Barnsbee LN, et al. Best practice perioperative strategies and surgical techniques for preventing caesarean section surgical site infections: a systematic review of reviews and meta-analyses. Br J Obstet Gynaecol. 2018;125:956.CrossRef Martin EK, Beckmann MM, Barnsbee LN, et al. Best practice perioperative strategies and surgical techniques for preventing caesarean section surgical site infections: a systematic review of reviews and meta-analyses. Br J Obstet Gynaecol. 2018;125:956.CrossRef
13.
Zurück zum Zitat Steiner HL, Strand EA. Surgical-site infection in gynecologic surgery: pathophysiology and prevention. Am J Obstet Gynecol. 2017;217:121.CrossRef Steiner HL, Strand EA. Surgical-site infection in gynecologic surgery: pathophysiology and prevention. Am J Obstet Gynecol. 2017;217:121.CrossRef
14.
Zurück zum Zitat Van Eyk N, van Schalkwyk J. Antibiotic prophylaxis in gynaecologic procedures. J Obstet Gynaecol Can. 2012;34:382.CrossRef Van Eyk N, van Schalkwyk J. Antibiotic prophylaxis in gynaecologic procedures. J Obstet Gynaecol Can. 2012;34:382.CrossRef
15.
Zurück zum Zitat Anger JT, Litwin MS, Wang Q, et al. Complications of sling surgery among female medicare beneficiaries. Obstet Gynecol. 2007;109:707.CrossRef Anger JT, Litwin MS, Wang Q, et al. Complications of sling surgery among female medicare beneficiaries. Obstet Gynecol. 2007;109:707.CrossRef
16.
Zurück zum Zitat Nygaard I, Brubaker L, Chai TC, et al. Risk factors for urinary tract infection following incontinence surgery. Int Urogynecol J. 2011;22:1255.CrossRef Nygaard I, Brubaker L, Chai TC, et al. Risk factors for urinary tract infection following incontinence surgery. Int Urogynecol J. 2011;22:1255.CrossRef
17.
Zurück zum Zitat Chung CP, Kuehl TJ, Harris SK, et al. Incidence and risk factors of postoperative urinary tract infection after uterosacral ligament suspension. Int Urogynecol J. 2012;23:947.CrossRef Chung CP, Kuehl TJ, Harris SK, et al. Incidence and risk factors of postoperative urinary tract infection after uterosacral ligament suspension. Int Urogynecol J. 2012;23:947.CrossRef
18.
Zurück zum Zitat Wei JT, Nygaard I, Richter HE, et al. A midurethral sling to reduce incontinence after vaginal prolapse repair. N Engl J Med. 2012;366:2358.CrossRef Wei JT, Nygaard I, Richter HE, et al. A midurethral sling to reduce incontinence after vaginal prolapse repair. N Engl J Med. 2012;366:2358.CrossRef
19.
Zurück zum Zitat El-Nashar SA, Singh R, Schmitt JJ, et al. Urinary tract infection after hysterectomy for benign gynecologic conditions or pelvic reconstructive surgery. Obstet Gynecol. 2018;132:1347-1357. El-Nashar SA, Singh R, Schmitt JJ, et al. Urinary tract infection after hysterectomy for benign gynecologic conditions or pelvic reconstructive surgery. Obstet Gynecol. 2018;132:1347-1357.
20.
Zurück zum Zitat Yoshikawa TT. Epidemiology and unique aspects of aging and infectious diseases. Clin Infect Dis. 2000;30:931.CrossRef Yoshikawa TT. Epidemiology and unique aspects of aging and infectious diseases. Clin Infect Dis. 2000;30:931.CrossRef
21.
Zurück zum Zitat Castle SC. Clinical relevance of age-related immune dysfunction. Clin Infect Dis. 2000;31:578.CrossRef Castle SC. Clinical relevance of age-related immune dysfunction. Clin Infect Dis. 2000;31:578.CrossRef
22.
Zurück zum Zitat Liu F, Ling Z, Xiao Y, et al. Characterization of the urinary microbiota of elderly women and the effects of type 2 diabetes and urinary tract infections on the microbiota. Oncotarget. 2017;8:678. Liu F, Ling Z, Xiao Y, et al. Characterization of the urinary microbiota of elderly women and the effects of type 2 diabetes and urinary tract infections on the microbiota. Oncotarget. 2017;8:678.
23.
Zurück zum Zitat Simmering JE, Tang F, Cavanaugh JE, et al. The increase in hospitalizations for urinary tract infections and the associated costs in the United States, 1998-2011. Open Forum Infect Dis. 2017;4:1.CrossRef Simmering JE, Tang F, Cavanaugh JE, et al. The increase in hospitalizations for urinary tract infections and the associated costs in the United States, 1998-2011. Open Forum Infect Dis. 2017;4:1.CrossRef
24.
Zurück zum Zitat Sutkin G, Alperin M, Meyn L, et al. Symptomatic urinary tract infections after surgery for prolapse and/or incontinence. Int Urogynecol J. 2010;21:955.CrossRef Sutkin G, Alperin M, Meyn L, et al. Symptomatic urinary tract infections after surgery for prolapse and/or incontinence. Int Urogynecol J. 2010;21:955.CrossRef
25.
Zurück zum Zitat Hakvoort RA, Thijs SD, Bouwmeester FW, et al. Comparing clean intermittent catheterization and transurethral indwelling catheterization for incomplete voiding after vaginal prolapse surgery: a multicenter randomized trial. BJOG. 2011;118:1055.CrossRef Hakvoort RA, Thijs SD, Bouwmeester FW, et al. Comparing clean intermittent catheterization and transurethral indwelling catheterization for incomplete voiding after vaginal prolapse surgery: a multicenter randomized trial. BJOG. 2011;118:1055.CrossRef
26.
Zurück zum Zitat Gotoh M, Kobayashi T, Sogabe K. Characterization of symptom bother and health-related quality of life in Japanese female patients with overactive bladder. Neurourol Urodyn. 2015;34:730.CrossRef Gotoh M, Kobayashi T, Sogabe K. Characterization of symptom bother and health-related quality of life in Japanese female patients with overactive bladder. Neurourol Urodyn. 2015;34:730.CrossRef
27.
Zurück zum Zitat Fok CS, McKinley K, Mueller ER, et al. Day of surgery urine cultures identify urogynecologic patients at increased risk for postoperative urinary tract infection. J Urol. 2013;189:1721.CrossRef Fok CS, McKinley K, Mueller ER, et al. Day of surgery urine cultures identify urogynecologic patients at increased risk for postoperative urinary tract infection. J Urol. 2013;189:1721.CrossRef
28.
Zurück zum Zitat Sutkin G, Lowder JL, Smith KJ. Prophylactic antibiotics to prevent urinary tract infection during clean intermittent self-catheterization (CICS) for management of voiding dysfunction after prolapse and incontinence surgery: a decision analysis. Int Urogynecol J. 2009;20:933.CrossRef Sutkin G, Lowder JL, Smith KJ. Prophylactic antibiotics to prevent urinary tract infection during clean intermittent self-catheterization (CICS) for management of voiding dysfunction after prolapse and incontinence surgery: a decision analysis. Int Urogynecol J. 2009;20:933.CrossRef
29.
Zurück zum Zitat Foxman B, Cronenwett AE, Spino C, et al. Cranberry juice capsules and urinary tract infection after surgery: results of a randomized trial. Am J Obstet Gynecol. 2015;213:e1.CrossRef Foxman B, Cronenwett AE, Spino C, et al. Cranberry juice capsules and urinary tract infection after surgery: results of a randomized trial. Am J Obstet Gynecol. 2015;213:e1.CrossRef
Metadaten
Titel
Urinary tract infection after clean-contaminated pelvic surgery: a retrospective cohort study and prediction model
verfasst von
May Sara Sanaee
Kathy Pan
Terry Lee
Nicole A. Koenig
Roxana Geoffrion
Publikationsdatum
31.10.2019
Verlag
Springer International Publishing
Erschienen in
International Urogynecology Journal / Ausgabe 9/2020
Print ISSN: 0937-3462
Elektronische ISSN: 1433-3023
DOI
https://doi.org/10.1007/s00192-019-04119-0

Weitere Artikel der Ausgabe 9/2020

International Urogynecology Journal 9/2020 Zur Ausgabe

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.