Urinary tract infection is associated with hypokalemia: a case control study

Hypokalemia is a common electrolyte abnormality in hospitalized patients. Unrecognized hypokalemia may trigger arrhythmias [1] and is associated with increased mortality in patients with chronic diseases such as heart failure, diabetes, or chronic kidney disease [2, 3]. Urinary tract infection (UTI) is a common bacterial infection in women and the elderly [4‐6]. Clinical manifestations of UTI include dysuria, frequency, urgency, fever, nausea, vomit, and gross hematuria. It may not be surprised that hypokalemia may be occurred because of increased potassium loss after vomit and fever. However, the association between UTI and hypokalemia is not clear [7‐11]. We observed that hypokalemia is common among UTI patients in clinical settings. This study was conducted to determine the association between UTI and hypokalemia. Inpatients were selected because serum potassium is rarely measured in outpatient settings as UTI has not been considered as a risk factor for hypokalemia.

We extracted data from the Longitudinal Health Insurance Database 2005 (LHID2005) as prescribed in the previous study [12]. The dataset used in this study is a de-identified secondary data and is released to the public for research purposes. A review of the institutional review board is not required. All inpatients with UTI between 1 January 2000 and 31 December 2008 were extracted. The first hospitalization for UTI was selected in the patients with more than one episode of UTI. The control patients were patients who are hospitalized for other reasons with matching for confoundings at a 1:1 ratio. The confoundings include cerebrovascular accident (CVA), chronic obstructive pulmonary disease (COPD), diabetes mellitus (DM), hypertension (HTN), acute kidney injury (AKI), chronic kidney disease (CKD), Cushing syndrome, hyperthyroidism, leukorrhea, medications, and urethral catheterization. These confoundings were used because they are associated with UTI or hypokalemia in the literature.

The patients hospitalized with UTI were identified with ICD-9-CM code 599 on discharge. Patients on dialysis were excluded in this study because pyuria is common in auric dialysis patients. The development of hypokalemia was identified using ICD-9-CM code (276.8) in the same hospitalization. The comorbidities diagnosed before the episode of UTI in at least 3 visits were retrieved. The comorbidities include CVA (ICD-9-CM code 430–436 and 438), COPD (490–496), DM (250), HTN (401–405), CHF (428), AKI (584.9), CKD (585), Cushing’s syndrome (255.0), hyperthyroidism (242), hypothyroidism (244), alkalosis (276.3), diarrhea (787.91), malnutrition (269.9, 262, 263), poor intake (783.0), magnesium disorder (275.2), and leukorrhea (616 and 623.5). Urethral catheterization in 1 week before hospitalization was identify using procedure code 47013–47014. Recurrent UTI was defined as individuals who had more than two episodes of UTI in 6 months or three episodes in 1 year [13]. Medications used for more than 14 days in 1 month before the UTI diagnosed were extracted. Medications include potassium-sparing diuretics (ATC code C03D, C03E), thiazides (C03A, C03B), sulfonamides (C03CA01, C03CA02), beta-2-adrenoreceptor agonists (R03CC), xanthines (R03DA, R03DB), antibiotics (J01CA, J01CR, J01GB, A01AB04), meropenem (J01DH02), insulin (A10), steroids (H02AB), potassium binders (V03AE01), and laxatives (A06AG07).

A total of 43,719 inpatients with UTI and matched control patients were analyzed (Table 1). 4540 (10.4%) UTI patients and 1842 (4.2%) control patients had hypokalemia (p < 0.001, chi-square test). The duration of hospitalization was longer in UTI patients 12.7 ± 24.8 days vs 7.4 ± 14.5 days in the control patients (p < 0.001). The average age of UTI patients was 63.5 ± 17.7 years old and 63.6 ± 18.2 years old in the control patients (p = 0.492). 39.3% of UTI patients and 39.2% of control patients were male. The percentage of patients with different comorbidities were similar in UTI patients and control patients after matching. The percentage of CVA was 28.8% in UTI patients and 28.4% in control patients. COPD 30.9 and 30.7%, DM 33.8 and 33.4%, HTN 59.2 and 58.9%, CHF 14.1 and 14.0%, AKI 0.3 and 0.3%, CKD 7.2 and 7.2%. Diarrhea, poor intake, and malnutrition were identified in 0.1% of the patients. The percentage of patients on potassium-sparing diuretics was 0.1% in UTI patients and 0.2% in control patients. Thiazides 0.6 and 0.6%, sulfonamides 0.4 and 0.5%, beta-2-adrenoreceptor agonists 0.7 and 0.7%, xanthiums 4.1 and 4.1%, antibiotics 0.7 and 0.7%, insulin 1.7 and 1.7%, steroids 1.5 and 1.5%, potassium binders 0.2 and 0.2%, laxatives 10.2 and 10.1%. The percentage of patients with urethral catheterization was 6.7% in both groups.

UTI was associated with hypokalemia in univariable and multivariable logistic regression (Table 2). The ORs were 2.48 (95% CI: 2.33–2.64, p < 0.001) in univariable logistic regression and 2.27 (95% CI: 2.13–2.41, p < 0.001) in multivariable logistic regression. Factors associated with hypokalemia in univariable logistic regression include age, CVA, COPD, DM, HTN, CHF, CKD, diarrhea, potassium-sparing diuretics, thiazides, sulfonamides, beta-2-adrenoreceptor agonists, xanthines, steroids, and laxatives. DM, CKD, beta-2-adrenoreceptor agonists, and steroids were not significantly associated with hypokalemia in multivariable logistic regression. The ORs of age was 1.01 (95% CI: 1.01–1.01) for every one additional year, CVA 1.29 (95% CI: 1.20–1.39), COPD 1.47 (95% CI: 1.37–1.57), HTN 1.56 (95% CI: 1.44–1.68), CHF 1.40 (95% CI: 1.28–1.53), diarrhea 2.25 (95% CI: 1.24–3.82), thiazides 1.57 (95% CI: 1.21–2.00), sulfonamides 1.44 (95% CI: 1.03–1.97), xanthines 1.44 (95% CI: 1.22–1.69), and laxatives 1.32 (95% CI: 1.16–1.52).

Recurrent UTI was significantly associated with hypokalemia in UTI patients (Table 3). The ORs were 1.31 (95% CI: 1.21–1.41) in univariable logistic regression and 1.13 (95% CI: 1.05–1.23) in multivariable logistic regression. Patient’s age, CVA, COPD, HTN, CHF, thiazides, sulfonamides, xanthines, and laxatives were independently associated with hypokalemia in UTI patients in univariable logistic regression, but diarrhea was not. The OR of age in the multivariable logistic regression was 1.01 (95% CI: 1.01–1.01), CVA 1.16 (95% CI: 1.08–1.24), COPD 1.45 (95% CI: 1.35–1.55), HTN 1.42 (95% CI: 1.31–1.53), CHF 1.41 (95% CI: 1.31–1.53), xanthines 1.42 (95% CI: 1.25–1.62), and laxatives 1.29 (95% CI: 1.17–1.41).

In this case-control cross-sectional study, we demonstrated the association between UTI and hypokalemia among inpatients. This finding is supported by the increased OR of hypokalemia in the multivariable logistic regression. The association between hypokalemia and UTI is independent of comorbidities and mediations. Besides, recurrent UTI is also associated with hypokalemia in UTI patients. Hypokalemia in UTI may explain the cardiac arrest following infectious disease in the previous study [14]. Inpatients with UTI were selected in this study because the serum potassium was more likely to be measured in inpatient settings. The development of hypokalemia in the patients with UTI may be explained by multiple factors including renal [9, 15, 16], medications [17], gastrointestinal loss. Medications including thiazides, sulfonamides, xanthines, and laxatives were independently associated with hypokalemia. We hypothesized that hypokalemia developed because of renal potassium loss. The renal tubule potassium resorption was impaired after tubule injury in UTI and therefore the urine potassium loss is increased [18, 19]. We measured the urine potassium of several UTI patients (data not shown) and the urine potassium secretion was increased in patients with UTI. More studies are needed to verify our findings.

Because hypokalemia may be related to multiple comorbidities, we include comorbidities that may be associated with both UTI [20, 21] and hypokalemia [22] in the analysis. DM, CKD, potassium-sparing diuretics, beta-2-adrenoreceptor agonists, and steroids were associated with hypokalemia in univariable regression but not in multivariable regression. This suggests that these may be not major contributors to hypokalemia in UTI patients. A few patients (0.1%) had diarrhea, malnutrition, or poor intake in our study. We suspected these conditions were underdiagnosed because physicians rarely coded these conditions in the diagnosis. Although the numbers of patients are limited, diarrhea was associated with hypokalemia in univariable and multivariable regressions. Duration of hospitalization, alkalosis, malnutrition, poor intake, magnesium disorder, and meropenem [23] were analyzed and was not linked to hypokalemia.

Urinary tract infection is associated with an increased risk of hypokalemia and measurements of serum potassium should be considered in clinical practice. UTI and hypokalemia are associated with multiple chronic diseases and medications. The association of hypokalemia and UTI is independent of comorbidities and medications.