The authors declare that they have no competing interests.
RDC conceived of the study, and participated in its design and coordination and helped to draft the manuscript. ACLGM carried out the microbiological assay and the test of surface change in the acrylic resin. EOL participated in the design of the study and coordination and helped to performed the microbiological assay. AUDB participated in the design of the study and performed the statistical analysis. JAO participated in the preparation of specimens in acrylic resin and helped to draft the manuscript. ALC carried out the test of color change in the acrylic resin specimens. All authors read and approved the final manuscript.
Given the high prevalence of oral candidiasis and the restricted number of antifungal agents available to control infection, this study investigated the in vitro antifungal activity of alcohol vinegar on Candida spp. and its effect on the physical properties of acrylic resins.
Tests to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of vinegar alcohol (0.04 g/ml of acetic acid) and nystatin (control) were performed. The antifungal activity of alcohol vinegar was assessed through microbial growth kinetic assays and inhibition of Candida albicans adhesion to acrylic resin at different intervals of time. Surface roughness and color of the acrylic resin were analyzed using a roughness meter and color analyzer device.
Alcohol vinegar showed MIC75% and MFC62.5% of 2.5 mg/ml, with fungicidal effect from 120 min, differing from nystatin (p < 0.0001), which showed fungistatic effect. Alcohol vinegar caused greater inhibition of C. albicans adhesion to the acrylic resin (p ≤ 0.001) compared to nystatin and did not change the roughness and color parameters of the material.
Alcohol vinegar showed antifungal properties against Candida strains and caused no physical changes to the acrylic resin.
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- Use of alcohol vinegar in the inhibition of Candida spp. and its effect on the physical properties of acrylic resins
Ricardo Dias de Castro
Ana Carolina Loureiro Gama Mota
Edeltrudes de Oliveira Lima
André Ulisses Dantas Batista
Julyana de Araújo Oliveira
Alessandro Leite Cavalcanti
- BioMed Central
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