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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Oral Health 1/2015

Use of alcohol vinegar in the inhibition of Candida spp. and its effect on the physical properties of acrylic resins

Zeitschrift:
BMC Oral Health > Ausgabe 1/2015
Autoren:
Ricardo Dias de Castro, Ana Carolina Loureiro Gama Mota, Edeltrudes de Oliveira Lima, André Ulisses Dantas Batista, Julyana de Araújo Oliveira, Alessandro Leite Cavalcanti
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

RDC conceived of the study, and participated in its design and coordination and helped to draft the manuscript. ACLGM carried out the microbiological assay and the test of surface change in the acrylic resin. EOL participated in the design of the study and coordination and helped to performed the microbiological assay. AUDB participated in the design of the study and performed the statistical analysis. JAO participated in the preparation of specimens in acrylic resin and helped to draft the manuscript. ALC carried out the test of color change in the acrylic resin specimens. All authors read and approved the final manuscript.

Abstract

Background

Given the high prevalence of oral candidiasis and the restricted number of antifungal agents available to control infection, this study investigated the in vitro antifungal activity of alcohol vinegar on Candida spp. and its effect on the physical properties of acrylic resins.

Methods

Tests to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of vinegar alcohol (0.04 g/ml of acetic acid) and nystatin (control) were performed. The antifungal activity of alcohol vinegar was assessed through microbial growth kinetic assays and inhibition of Candida albicans adhesion to acrylic resin at different intervals of time. Surface roughness and color of the acrylic resin were analyzed using a roughness meter and color analyzer device.

Results

Alcohol vinegar showed MIC75% and MFC62.5% of 2.5 mg/ml, with fungicidal effect from 120 min, differing from nystatin (p < 0.0001), which showed fungistatic effect. Alcohol vinegar caused greater inhibition of C. albicans adhesion to the acrylic resin (p ≤ 0.001) compared to nystatin and did not change the roughness and color parameters of the material.

Conclusion

Alcohol vinegar showed antifungal properties against Candida strains and caused no physical changes to the acrylic resin.
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