Background
Methods
Design overview
Settings
Patients
Data collection
Contextual variables
Statistical methods
Results
Study Cohort | Women | Men | p-value | |
---|---|---|---|---|
Number | n = 499 | n = 249 | n = 250 | n = 499 |
Age median(IQR) | 74 (62-81) | 74 (62-81) | 0.96 | |
Admission to invasive heart center | 89 (35.6) | 92 (36.8) | 0.78 | |
Risk factors | ||||
Family history of CVD | 80 (32.1) | 61 (24.4) | 0.06 | |
Arterial hypertension | 122 (49.0) | 119 (47.6) | 0.76 | |
Diabetes mellitus | 36 (14.5) | 39 (15.6) | 0.72 | |
Hypercholesteroleamia | 80 (32.1) | 85 (34.0) | 0.7 | |
Smoking | 69 (27.7) | 82 (32.8) | 0.08 | |
Prior PCI | 6 (2.4) | 16 (6.4) | 0.047 | |
Prior CABG | 6 (2.4) | 21 (8.4) | 0.005 | |
Previous MI | 9 (3.6) | 9 (3.6) | 0.99 | |
Co-morbidities | ||||
Heart-related | ||||
Known IHD | 20 (8.0) | 46 (18.4) | 0.001 | |
Heart failure | 35 (14.1) | 19 (7.6) | 0.020 | |
Valvular heart disease | 26 (10.4) | 19 (7.6) | 0.27 | |
Atrial fibrillation | 39 (15.7) | 40 (16.0) | 0.92 | |
Other | ||||
COPD | 23 (9.2) | 27 (10.8) | 0.56 | |
PAOD | 14 (5.6) | 20 (8.0) | 0.29 | |
Renal failure | 11 (4.4) | 9 (3.6) | 0.66 | |
Neoplasia | 4 (1.6) | 12 (4.8) | 0.07 | |
Liver failure | 0 (0.0) | 1 (0.4) | 1.00 | |
Stroke | 25 (10.0) | 31 (12.4) | 0.40 | |
Symptoms | ||||
Chest pain | 189 (75.9) | 203 (81.2) | 0.15 | |
Dyspnea | 96 (38.6) | 81 (32.4) | 0.15 | |
Neck pain | 25 (10.0) | 21 (8.4) | 0.53 | |
Diaphoresis | 30 (12.1) | 36 (14.4) | 0.44 | |
Nausea/vomiting | 47 (18.9) | 31 (12.4) | 0.046 | |
Fatigue | 7 (2.8) | 8 (3.2) | 0.8 | |
Abdominal pain | 14 (5.6) | 8 (3.2) | 0.19 | |
Back pain | 27 (10.8) | 21 (8.4) | 0.36 | |
Cardiac arrest | 15 (6.0) | 14 (5.6) | 0.84 | |
Other competing acute conditions at admission?a | 42 (16.9) | 34 (13.6) | 0.31 | |
ECG | ||||
ST-elevations | 104 (41.8) | 107 (42.8) | 0.82 | |
ST-depressions | 59 (23.7) | 86 (34.4) | 0.008 | |
LBBB | 24 (9.6) | 16 (6.4) | 0.18 | |
Q-wave | 37 (14.9) | 38 (15.2) | 0.92 | |
Systolic blood pressuree | 140 (126-160) | 137 (119.5-155) | 0.013 | |
Heart ratee | 88 (70-105) | 81 (66-97) | 0.008 | |
Troponin level Ib,c,e | 3.2 (1.4-9.2) | 2.5 (1.0-8.4) | 0.25 | |
Troponin level IIb,d,e | 4.5 (2.1-12.5) | 6.1 (2.0-35) | 0.14 | |
Peak troponin levelb,e | 12.4 (4.7-44.3) | 20.3 (4.1-73.6) | 0.23 | |
Creatinine levele | 70 (59-86.5) | 87 (74-100) | <0.001 |
Female | Male | p-value | |
---|---|---|---|
Uncontrolled hypertension | 29 (13.1) | 18 (8.0) | 0.08 |
Fever or active infection | 0 (0.0) | 1 (1.47) | 0.5 |
Malignant or terminal disease | 11 (5.5) | 4 (2.2) | 0.12 |
Risk of bleeding | 23 (14.7) | 26 (17.3) | 0.54 |
Ongoing bleeding | 5 (2.0) | 9 (3.6) | 0.42 |
Moderate/severe heart failure | 8 (3.2) | 5 (2.0) | 0.6 |
Previous allergy to contrast | 0(0.0) | 0(0.0) | NA |
Digoxin intoxication | 0 (0.0) | 0 (0.0) | NA |
Electrolyte-disturbances (4.6 mM < potassium level < 3.5 mM) | 49 (24.6) | 29 (15.8) | 0.031 |
At least one of the above mentioned relative contraindication (excluding heart failure) | 130 (52.0) | 120 (48.0) | 0.060 |
OR | 95 % CI | p-value | |
---|---|---|---|
Female | 0.79 | 0.52-1.20 | 0.28 |
Age | |||
< 60 years | Reference | ||
60-69 years | 1.26 | 0.33-4.84 | 0.73 |
70-79 years | 0.26 | 0.1-0.72 | <0.001 |
≥ 80 years | 0.04 | 0.02-0.10 | <0.001 |
Admission to a hospital with invasive cardiac facilities | 4.23 | 2.43-7.36 | <0.001 |
Risk factors | |||
Family history of CVD | 6.99 | 3.31-14.79 | <0.001 |
Arterial hypertension | 1.67 | 1.09-2.55 | 0.019 |
Diabetes mellitus | 0.72 | 0.42-1.26 | 0.25 |
Hypercholesteroleamia | 4.21 | 2.36-7.52 | <0.001 |
Smoking | 1.91 | 1.45-2.52 | <0.001 |
Prior PCI | 3.07 | 0.71-13.33 | 0.14 |
Prior CABG | 0.41 | 0.18-0.90 | 0.027 |
Previous AMI | 1.5 | 0.43-5.28 | 0.53 |
Co-morbidities | |||
Heart-related | |||
Known IHD | 1.12 | 0.59-2.10 | 0.73 |
Heart failure | 0.67 | 0.36-1.25 | 0.21 |
Valvular heart disease | 0.40 | 0.21-0.76 | 0.005 |
Atrial Fibrillation | 0.36 | 0.21-0.60 | <0.001 |
Other | |||
COPD | 0.33 | 0.18-0.60 | <0.001 |
PAOD | 0.81 | 0.37-1.79 | 0.60 |
Renal failure | 0.11 | 0.04-0.30 | <0.001 |
Neoplasia | 0.88 | 0.28-2.80 | 0.84 |
Liver failure | - | - | - |
Stroke | 0.19 | 0.10-0.33 | <0.001 |
Symptoms | |||
Chest pain | 5.64 | 3.53-9.00 | <0.001 |
Dyspnea | 0.47 | 0.31-0.72 | 0.001 |
Neck pain | 0.94 | 0.46-1.91 | 0.86 |
Diaphoresis | 1.01 | 0.54-1.87 | 0.98 |
Nausea/vomiting | 0.71 | 0.41-1.23 | 0.22 |
Fatigue | 0.81 | 0.25-2.59 | 0.72 |
Abdominal pain | 0.19 | 0.08-0.45 | <0.001 |
Back pain | 1.54 | 0.70-3.38 | 0.29 |
Cardiac arrest | 0.76 | 0.33-1.78 | 0.53 |
ECG | |||
ST-elevations | 5.36 | 3.12-9.21 | <0.001 |
ST-depressions | 0.69 | 0.44-1.08 | 0.108 |
LBBB | 0.52 | 0.26-1.03 | 0.06 |
Q-wave | 0.62 | 0.36-1.06 | 0.08 |
Other | |||
Systolic BP | 1.01 | 1.00-1.02 | 0.024 |
Diastolic BP | 1.02 | 1.01-1.04 | 0.002 |
HR | 0.99 | 0.98-1.00 | 0.010 |
Troponine 1 | 0.99 | 0.99-1.00 | 0.028 |
Troponine 2 | 1.00 | 1.00-1.00 | 0.34 |
Peak troponine | 1.00 | 1.00-1.00 | 0.59 |
Creatinine | 0.98 | 0.97-0.99 | <0.001 |
OR | 95 % CI | p-value | |
---|---|---|---|
Age | 0.90 | 0.87-0.94 | <0.001 |
Admission to center | 2.8 | 1.27-6.21 | 0.011 |
Family history of CVD | 2.35 | 0.92-5.97 | 0.072 |
Arteriel hypertension | 2.38 | 1.23-4.62 | 0.010 |
Hypercholesteroleamia | 3.00 | 1.38-6.48 | 0.005 |
Smoking | 2.03 | 1.39-2.97 | <0.001 |
Prior CABG | 0.25 | 0.06-0.98 | 0.047 |
Co-morbidities | |||
Heart-related | |||
Known IHD | 3.85 | 1.27-11.63 | 0.017 |
Other | |||
COPD | 0.37 | 0.15-0.87 | 0.023 |
Renal failure | 0.20 | 0.05-0.83 | 0.027 |
Stroke | 0.31 | 0.13-0.70 | 0.005 |
Symptoms | |||
Chest pain | 2.99 | 1.58-5.67 | 0.001 |
ECG | |||
ST-elevations | 4.44 | 2.05-9.60 | 0.000 |
Q-wave | 0.35 | 0.15-0.78 | 0.011 |