Use of Hepatitis C-Positive Donor Livers in Liver Transplantation
- 26.01.2017
- Hepatitis C (J Ahn and A Aronsohn, Section Editors)
- Verfasst von
- Daniel Bushyhead
- David Goldberg
- Erschienen in
- Current Hepatology Reports | Ausgabe 1/2017
Abstract
Purpose of Review
The purpose of this article is to review recent literature regarding the use of hepatitis C virus (HCV)-positive donor livers in liver transplantation. Given the prevalence of HCV-positive patients on the waitlist coupled with high waitlist mortality, use of HCV-positive livers may be a means to meet patient needs. This review seeks to primarily answer the following questions: can HCV-positive livers be used safely and effectively? Are new direct-acting antiviral medications safe and effective in HCV-positive liver recipients?
Recent Findings
Use of HCV-positive donor livers for liver transplantation in HCV-positive recipients is increasing. These donor livers have equivalent patient and graft survival when compared to HCV-negative donor livers in HCV-positive liver transplant recipients. Recent studies suggest that use of direct-acting antiviral medications in HCV-positive liver transplant recipients can be successful, although there is insufficient data for their use in recipients of HCV-positive donor livers.
Summary
HCV-positive donor livers may be safely and effectively used in HCV-positive liver transplant recipients. Direct-acting antiviral medications appear safe and effective in HCV-positive liver transplant recipients, but data on their efficacy in HCV-positive donor liver transplant recipients are limited. Future research should focus on the use of HCV-positive donor livers in HCV-negative liver transplant recipients.
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- Titel
- Use of Hepatitis C-Positive Donor Livers in Liver Transplantation
- Verfasst von
-
Daniel Bushyhead
David Goldberg
- Publikationsdatum
- 26.01.2017
- Verlag
- Springer US
- Erschienen in
-
Current Hepatology Reports / Ausgabe 1/2017
Elektronische ISSN: 2195-9595 - DOI
- https://doi.org/10.1007/s11901-017-0327-0
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