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Current Breast Cancer Reports

Erschienen in:

19.11.2018 | Systemic Therapies (M Liu and T Haddad, Section Editors)

Use of Multigene Prognostic Indices to Guide Clinical Decision-Making Regarding Adjuvant Systemic Therapy

verfasst von: Karthik V. Giridhar, Minetta C. Liu

Erschienen in: Current Breast Cancer Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

Several multigene assays have been developed to guide adjuvant therapy decisions for early-stage invasive breast cancer, including the 21-gene recurrence score, 70-gene assay, EndoPredict, PAM50 Risk of Recurrence, and Breast Cancer Index.

Recent Findings

Each assay has varying levels of evidence to support the analytical validity, clinical validity, and clinical utility in providing prognostic information complementary to conventional clinical characteristics. While each test is able to identify patients at low risk of distant recurrence, understanding the differences in development and studies used for clinical validation is important for guiding test selection for each unique patient.

Summary

We provide an in depth analysis on each of these commercially available multigene tests to help providers determine which test may be most useful in a particular clinical context.

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Titel: Use of Multigene Prognostic Indices to Guide Clinical Decision-Making Regarding Adjuvant Systemic Therapy
verfasst von: Karthik V. Giridhar
Minetta C. Liu
Publikationsdatum: 19.11.2018
Verlag: Springer US
Erschienen in: Current Breast Cancer Reports / Ausgabe 4/2018
Print ISSN: 1943-4588
Elektronische ISSN: 1943-4596
DOI: https://doi.org/10.1007/s12609-018-0297-4

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Abstract

Purpose of Review

Recent Findings

Summary

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