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Erschienen in: Wiener klinische Wochenschrift 7-8/2016

12.01.2016 | short report

Use of nonsteroidal anti-inflammatory drugs and renal failure in nursing home residents—results of the study “Inappropriate Medication in Patients with Renal Insufficiency in Nursing Homes”

verfasst von: Dr. rer. nat. Michael Dörks, Prof. Dr. med. Stefan Herget-Rosenthal, PD. Dr. med. Guido Schmiemann, MPH, Prof. Dr. P.H. Falk Hoffmann, MPH

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 7-8/2016

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Summary

Background

Use of potentially inappropriate medications may result in increased morbidity, mortality and resource utilisation. Due to polypharmacy and age-related decline in renal function the elderly population is at particular risk. Therefore, the Beers Criteria include use of nonsteroidal anti-inflammatory drugs in chronic renal failure stage 4 and 5 as these drugs may worsen renal function. According to the summary of product characteristics, the nonsteroidal anti-inflammatory drugs ibuprofen and diclofenac are contraindicated in these patients.
Objective was to assess the extent of nonsteroidal anti-inflammatory drug use in nursing homes with a focus on residents with severe renal failure.

Methods

Multi-centre cross-sectional study in 21 German nursing homes. The study population comprised residents for whom at least one serum creatinine value and information about sex were available, so that creatinine clearance rate could be estimated.

Results

In all, 685 of 852 residents were included as they fulfilled the abovementioned criteria. Renal failure was severe (estimated creatinine clearance rate < 30 ml/min) in 106 residents (15.5 %). Approximately one-fifth was treated with at least one nonsteroidal anti-inflammatory drug in both the total study population (20.3 %) and that with severe renal failure (20.8 %). With one exception, all residents prescribed nonsteroidal anti-inflammatory drugs with severe renal failure were treated with at least one nonsteroidal anti-inflammatory drug that was contraindicated due to the underlying renal function.

Conclusions

Notwithstanding their classification as potentially inappropriate medications and underlying contraindications, use of nonsteroidal anti-inflammatory drugs is common among nursing home residents with severe renal failure.
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Metadaten
Titel
Use of nonsteroidal anti-inflammatory drugs and renal failure in nursing home residents—results of the study “Inappropriate Medication in Patients with Renal Insufficiency in Nursing Homes”
verfasst von
Dr. rer. nat. Michael Dörks
Prof. Dr. med. Stefan Herget-Rosenthal
PD. Dr. med. Guido Schmiemann, MPH
Prof. Dr. P.H. Falk Hoffmann, MPH
Publikationsdatum
12.01.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 7-8/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-015-0919-z

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