Introduction
Methods
Study Design
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A/BPO + supplementary educational material (SEM): supplementary patient educational material in addition to SOCPE (package insert and oral instruction) with visits at baseline and weeks 6 and 12. The SEM included a 3-min video about the mode of action of A/BPO, the method of application, treatment expectations, and management of irritation. Subjects also received an information card containing the key messages of the video, as well as additional information about acne and A/BPO available online. Briefly, the key messages contained in the video are as follows:
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Use A/BPO once a day in the evening.
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Cleanse all areas affected by acne with a gentle cleanser and dry with a clean towel.
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Use one small pea-sized amount of A/BPO spread over all affected areas, not just on the spots.
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Moisturize afterwards to help improve the condition of the skin.
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You should notice an improvement in 1–4 weeks.
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Manage irritation if it occurs by applying the treatment every other day at first.
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A/BPO + more visits: subjects received only SOCPE. However, these subjects attended two additional visits (baseline and weeks 3, 6, 9, and 12).
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A/BPO alone: subjects received only SOCPE with visits at baseline and weeks 6 and 12.
Assessments
Statistical Analysis
Results
Disposition and Baseline Disease Characteristics
A/BPO + educational material (N = 33) | A/BPO + more visits (N = 31) | A/BPO (N = 33) | Total (N = 97) | |
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Gender | ||||
Male | 11 (33.3%) | 12 (38.7%) | 7 (21.2%) | 30 (30.9%) |
Female | 22 (66.7%) | 19 (61.3%) | 26 (78.8%) | 67 (69.1%) |
Age | ||||
Mean | 24.1 | 22.5 | 21.0 | 22.5 |
Min, max | 12, 49 | 12, 51 | 12, 44 | 12, 51 |
Race | ||||
White | 29 (87.9%) | 27 (87.1%) | 26 (78.8%) | 82 (84.5%) |
Asian | 3 (9.1%) | 4 (12.9%) | 6 (18.2%) | 13 (13.4%) |
Other | 1 (3.0%) | 0 | 1 (3.0%) | 2 (2.1%) |
Phototype | ||||
I | 2 (6.1%) | 2 (6.5%) | 3 (9.1%) | 7 (7.2%) |
II | 11 (33.3%) | 11 (35.5%) | 9 (27.3%) | 31 (32.0%) |
III | 14 (42.4%) | 12 (38.7%) | 13 (39.4%) | 39 (40.2%) |
IV | 5 (15.2%) | 4 (12.9%) | 6 (18.2%) | 15 (15.5%) |
V | 1 (3.0%) | 2 (6.5%) | 2 (6.1%) | 5 (5.2%) |
IIGA | ||||
1: Almost clear | 8 (24.2%) | 3 (9.7%) | 1 (3.0%) | 12 (12.4%) |
2: Mild | 17 (51.5%) | 20 (64.5%) | 22 (66.7%) | 59 (60.8%) |
3: Moderate | 8 (24.2%) | 8 (25.8%) | 10 (30.3%) | 26 (26.8%) |
Mean ± SD | 2.0 ± 0.7 | 2.2 ± 0.6 | 2.3 ± 0.5 | 2.1 ± 0.6 |
Acne history (duration in years) | ||||
Mean ± SD | 5.7 ± 9.3 | 4.7 ± 5.6 | 4.4 ± 4.6 | 4.9 ± 6.8 |