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Esophagus
Erschienen in:

08.08.2023 | Original Article

Usefulness of the aldehyde breath test for predicting metachronous recurrence in patients with esophageal squamous cell carcinoma and hypopharyngeal squamous cell carcinoma

verfasst von: Fumisato Sasaki, Seiichi Mawatari, Kohei Oda, Hiroki Yano, Hidehito Maeda, Akihito Tanaka, Shiho Arima, Kotaro Kumagai, Shiroh Tanoue, Shinichi Hashimoto, Shuji Kanmura, Akio Ido

Erschienen in: Esophagus | Ausgabe 4/2023

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Abstract

Background

The rate of metachronous recurrence after endoscopic submucosal dissection for early-stage esophageal squamous cell carcinoma and hypopharynx squamous cell carcinoma is as high (10–15%). The acetaldehyde breath test may detect acetaldehyde dehydrogenase 2 gene polymorphisms. Therefore, we evaluated its usefulness in assessing metachronous recurrence in patients with esophageal squamous cell carcinoma and hypopharynx squamous cell carcinoma.

Methods

A total of 76 patients underwent endoscopic submucosal dissection for esophageal squamous cell carcinoma and hypopharynx squamous cell carcinoma and were followed up for at least 3 years (non-recurrence group: 52 patients; recurrence group: 24 patients). The risk factors for carcinogenesis were compared between the recurrence and non-recurrence groups, and the acetaldehyde-to-ethanol ratio was assessed. The cutoff acetaldehyde-to-ethanol ratio that correlated with recurrence was established, and the cumulative recurrence rate was evaluated.

Results

The recurrence group had a higher acetaldehyde-to-ethanol ratio, daily alcohol consumption, and Lugol-voiding lesion grade than the non-recurrence group in the univariate analysis. The cutoff acetaldehyde-to-ethanol ratio for recurrence was 28.1 based on the receiver operating characteristic curve. The multivariate analysis revealed an acetaldehyde-to-ethanol ratio of > 28.1 and a Lugol-voiding lesion grade associated with carcinogenesis. Patients with an acetaldehyde-to-ethanol ratio of ≥ 28.1 had a significantly high recurrence rate using the Kaplan–Meier method.

Conclusions

The acetaldehyde-to-ethanol ratio detected using the acetaldehyde breath test could be a novel biomarker of metachronous recurrence after endoscopic submucosal dissection in patients with esophageal squamous cell carcinoma and hypopharynx squamous cell carcinoma.

Trial registration number

UMIN000040615.
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Metadaten
Titel
Usefulness of the aldehyde breath test for predicting metachronous recurrence in patients with esophageal squamous cell carcinoma and hypopharyngeal squamous cell carcinoma
verfasst von
Fumisato Sasaki
Seiichi Mawatari
Kohei Oda
Hiroki Yano
Hidehito Maeda
Akihito Tanaka
Shiho Arima
Kotaro Kumagai
Shiroh Tanoue
Shinichi Hashimoto
Shuji Kanmura
Akio Ido
Publikationsdatum
08.08.2023
Verlag
Springer Nature Singapore
Erschienen in
Esophagus / Ausgabe 4/2023
Print ISSN: 1612-9059
Elektronische ISSN: 1612-9067
DOI
https://doi.org/10.1007/s10388-023-01024-w

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