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Erschienen in: Osteoporosis International 4/2021

10.02.2021 | Letter to the Editor

Using health-economic evidence to support policy-level decision-making in Singapore—sensitivity analysis that provides further confidence in fracture probability-based cost-effective intervention thresholds

verfasst von: M. Chandran, G. Ganesan, K. B. Tan, J.-Y. Reginster, M. Hiligsmann

Erschienen in: Osteoporosis International | Ausgabe 4/2021

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Excerpt

FRAX®-based intervention thresholds (ITs) were identified in Singapore in 2018 [1]. Subsequently, in a separate study, the impact of age-dependent ITs was determined on a population-based sample [2]. The mean-weighted age-dependent thresholds identified in the two studies were mostly similar with a minor difference noted at older ages (e.g. at the age of 75 years, major osteoporotic fracture (MOF) IT being 24% for the former study vs 25.7% for the latter). The clinical impact of these minor differences noted at extremely old ages is unlikely to be significant and is presumed secondary to the small methodological differences between the two studies. …
Literatur
1.
Zurück zum Zitat Chandran M, McCloskey EV, Thu WPP, Logan S, Hao Y, Tay D, Ang WC, Aung TKK, Choo KS, Ali A, Yan SX, Huang XF, Liu XM, Yong EL, Lekamwasam S (2018) FRAX® based intervention thresholds for management of osteoporosis in Singaporean women. Arch Osteoporos 13(1):130CrossRef Chandran M, McCloskey EV, Thu WPP, Logan S, Hao Y, Tay D, Ang WC, Aung TKK, Choo KS, Ali A, Yan SX, Huang XF, Liu XM, Yong EL, Lekamwasam S (2018) FRAX® based intervention thresholds for management of osteoporosis in Singaporean women. Arch Osteoporos 13(1):130CrossRef
2.
Zurück zum Zitat Kanis JA, Chandran M, Chionh SB, Ganeson G, Harvey NC, Koh WP, Kwok T, Lau TC, Liu E, Lorentzon M, McCloskey EV, Tan KB, Vandenput L, Johansson H (2020) Use of age-dependent FRAX-based intervention thresholds for Singapore. Arch Osteoporos 15(1):104CrossRef Kanis JA, Chandran M, Chionh SB, Ganeson G, Harvey NC, Koh WP, Kwok T, Lau TC, Liu E, Lorentzon M, McCloskey EV, Tan KB, Vandenput L, Johansson H (2020) Use of age-dependent FRAX-based intervention thresholds for Singapore. Arch Osteoporos 15(1):104CrossRef
Metadaten
Titel
Using health-economic evidence to support policy-level decision-making in Singapore—sensitivity analysis that provides further confidence in fracture probability-based cost-effective intervention thresholds
verfasst von
M. Chandran
G. Ganesan
K. B. Tan
J.-Y. Reginster
M. Hiligsmann
Publikationsdatum
10.02.2021
Verlag
Springer London
Erschienen in
Osteoporosis International / Ausgabe 4/2021
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-021-05876-9

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