Erschienen in:
10.02.2021 | Letter to the Editor
Using health-economic evidence to support policy-level decision-making in Singapore—sensitivity analysis that provides further confidence in fracture probability-based cost-effective intervention thresholds
verfasst von:
M. Chandran, G. Ganesan, K. B. Tan, J.-Y. Reginster, M. Hiligsmann
Erschienen in:
Osteoporosis International
|
Ausgabe 4/2021
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Excerpt
FRAX®-based intervention thresholds (ITs) were identified in Singapore in 2018 [
1]. Subsequently, in a separate study, the impact of age-dependent ITs was determined on a population-based sample [
2]. The mean-weighted age-dependent thresholds identified in the two studies were mostly similar with a minor difference noted at older ages (e.g. at the age of 75 years, major osteoporotic fracture (MOF) IT being 24% for the former study vs 25.7% for the latter). The clinical impact of these minor differences noted at extremely old ages is unlikely to be significant and is presumed secondary to the small methodological differences between the two studies. …