Skip to main content
main-content

30.06.2017 | Therapeutics and Medical Management (S Jan de Beur and B Clarke, Section Editors) | Ausgabe 4/2017

Current Osteoporosis Reports 4/2017

Using Osteoporosis Therapies in Combination

Zeitschrift:
Current Osteoporosis Reports > Ausgabe 4/2017
Autor:
Michael R. McClung
Wichtige Hinweise
This article is part of the Topical Collection on Therapeutics and Medical Management

Abstract

Purpose of review

The objective of this review is to update evidence regarding the use of osteoporosis drugs in sequence or in combination to optimize increases in bone mass and strength.

Recent findings

Simultaneous use of denosumab plus teriparatide produces larger increases in BMD than does monotherapy. The use of bisphosphonates or denosumab after teriparatide results in progressive gains in BMD. When switching from bisphosphonates and especially denosumab to teriparatide, an overlap of 6-12 months may prevent the transient loss of BMD in cortical sites. Phase 3 trials document fracture risk reduction with anabolic therapy for 12-18 months followed by an anti-remodeling drug.

Summary

With the exception of adding teriparatide to ongoing denosumab therapy, there is little evidence to support the use of more than one osteoporosis drug at a time. In contrast, sequential therapy regimens of anabolic drugs followed by potent anti-remodeling agents will be the new standard for treating patients at imminent risk of fracture.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Bis zum 22.10. bestellen und 100 € sparen!

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 4/2017

Current Osteoporosis Reports 4/2017Zur Ausgabe

Pediatrics (L Ward and E Imel, Section Editors)

Denosumab: an Emerging Therapy in Pediatric Bone Disorders

Rare Bone Disease (C Langman and E Shore, Section Editors)

Melorheostosis: a Rare Sclerosing Bone Dysplasia

Cancer-induced Musculoskeletal Diseases (M Reagan and E Keller, Section Editors)

Hypoxia and Bone Metastatic Disease

Pediatrics (L Ward and E Imel, Section Editors)

Recent Discoveries in Monogenic Disorders of Childhood Bone Fragility

Neu im Fachgebiet Orthopädie und Unfallchirurgie

 

 

 
 

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Orthopädie und Unfallchirurgie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise