Background
Methods
Objectives of the study and study design
Subjects of the study
Transabdominal Doppler ultrasound
Acquisition of 2D Doppler velocity waveforms
Acquisition of 3D placental vascular indexes
ANA assay
Statistical analysis
Results
Clinical characteristics
RPL (n = 20) | RPL (n = 24) | Controls (n = 27) | One-way ANOVA | |||||
Not-treated | LMWH-treated | |||||||
ANA - (n = 10) | ANA + (n = 10) | ANA - (n = 10) | ANA + (n = 14) | ANA - (n = 11) | ANA + (n = 16) | F | P value | |
Age (years) | 34 + 5 | 35 + 6 | 36 + 4 | 35 + 5 | 36 + 2 | 36 + 3 | 0.4 | ns |
BMI (Kg/m2) | 25 + 4 | 26 + 5 | 24 + 4 | 24+ 5 | 24 + 3 | 26 + 2 | 0.78 | NS |
Number of miscarriages | 3 + 0.9 | 3 + 1 | 2.9 + 0.8 | 3.1 + 0.8 | – | – | 0.1 | NS |
Week of miscarriage | 8.4 + 2 | 8.7 + 2.6 | 8.5 + 2 | 9 + 2.5 | – | – | 0.16 | NS |
Blood pressure | 97,2 / 73,2 | 108,7 / 75,7 | 109,7 / 77,2 | 110,2 / 78,07 | 113,1 / 74,91 | 104,3 / 77,75 | 1,08/1,7 | NS |
gestational week of the delivery | 39,1 + 1,1 | 39,2 + 1,8 | 39,4 + 0,97 | 39,2 + 1,48 | 39,9 + 0,94 | 39,4 + 1,26 | 0,87 | NS |
Birth weight | 3228 + 269,2 | 3308 + 287 | 3436 + 313,5 | 3233 + 358,3 | 3279 + 368,0 | 3241 + 287,6 | 0,34 | NS |
Uterine arteries flow, vascularization indexes and antinuclear antibodies status
Control women | Not-treated RPL women | LMWH-treated RPL women | ||||
---|---|---|---|---|---|---|
ANA- | ANA+ | ANA- | ANA+ | ANA- | ANA+ | |
PI | 1.35 ± 0.52 | 1.16 ± 0.43 | 1.12 ± 0.21 | 1.31 ± 0.46 | 1.37 ± 0.48 | 1.26 ± 0.42 |
FI | 42.46 ± 2.81 | 40.53 ± 4.39 | 43.24 ± 8.46 | 38.71 ± 6.97 | 44.18 ± 6.85 | 46.22 ± 4.57 |
VFI | 5.41 ± 2.05 | 6.34 ± 4.51 | 9.31 ± 2.57 | 5.13 ± 2.1 | 4.93 ± 2.94 | 6.91 ± 5.32 |
VI | 12.79 ± 4.76 | 15.31 ± 9.3 | 20.35 ± 6.16 | 13.35 ± 5.32 | 8.61 ± 5.39 | 11.11 ± 4.09 |