The online version of this article (doi:10.1186/cc9250) contains supplementary material, which is available to authorized users.
YY is a member of the Pulsion Medical Systems medical advisory board. The other authors declare that they have no competing interests. There was no financial support for this study.
TT conceived of the study, participated in the design of study, performed the statistical analysis, and helped to draft the manuscript. SK, RT, and TK participated in the study design and helped to draft the manuscript. YY, KM, RO, HH, and HY participated in the study design and provided coordination. TA and TM participated in the design of study. All authors read and approved the final manuscript.
Gravimetric validation of single-indicator extravascular lung water (EVLW) and normal EVLW values has not been well studied in humans thus far. The aims of this study were (1) to validate the accuracy of EVLW measurement by single transpulmonary thermodilution with postmortem lung weight measurement in humans and (2) to define the statistically normal EVLW values.
We evaluated the correlation between pre-mortem EVLW value by single transpulmonary thermodilution and post-mortem lung weight from 30 consecutive autopsies completed within 48 hours following the final thermodilution measurement. A linear regression equation for the correlation was calculated. In order to clarify the normal lung weight value by statistical analysis, we conducted a literature search and obtained the normal reference ranges for post-mortem lung weight. These values were substituted into the equation for the correlation between EVLW and lung weight to estimate the normal EVLW values.
EVLW determined using transpulmonary single thermodilution correlated closely with post-mortem lung weight (r = 0.904, P < 0.001). A linear regression equation was calculated: EVLW (mL) = 0.56 × lung weight (g) - 58.0. The normal EVLW values indexed by predicted body weight were approximately 7.4 ± 3.3 mL/kg (7.5 ± 3.3 mL/kg for males and 7.3 ± 3.3 mL/kg for females).
A definite correlation exists between EVLW measured by the single-indicator transpulmonary thermodilution technique and post-mortem lung weight in humans. The normal EVLW value is approximately 7.4 ± 3.3 mL/kg.
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- Validation of extravascular lung water measurement by single transpulmonary thermodilution: human autopsy study
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