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Erschienen in: Neurological Sciences 12/2019

26.07.2019 | Original Article

Validation of the Italian version of the PSP Quality of Life questionnaire

verfasst von: Marina Picillo, Sofia Cuoco, Marianna Amboni, Francesco Paolo Bonifacio, Fabio Bruschi, Immacolata Carotenuto, Rosa De Micco, Anna De Rosa, Eleonora Del Prete, Francesca Di Biasio, Francesca Elifani, Roberto Erro, Margherita Fabbri, Marika Falla, Giulia Franco, Daniela Frosini, Sebastiano Galantucci, Giulia Lazzeri, Luca Magistrelli, Maria Chiara Malaguti, Anna Vera Milner, Brigida Minafra, Enrica Olivola, Andrea Pilotto, Cristina Rascunà, Maria Cristina Rizzetti, Tommaso Schirinzi, Barbara Borroni, Roberto Ceravolo, Alessio Di Fonzo, Roberta Marchese, Nicola B. Mercuri, Nicola Modugno, Alessandra Nicoletti, Alessandro Padovani, Gabriella Santangelo, Alessandro Stefani, Alessandro Tessitore, Maria Antonietta Volontè, Roberta Zangaglia, Mario Zappia, Maurizio Zibetti, Paolo Barone

Erschienen in: Neurological Sciences | Ausgabe 12/2019

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Abstract

Background

Progressive supranuclear palsy (PSP) is a rare rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. The use of health-related quality of life (HR-QoL) measures allows assessing changes in health status induced by therapeutic interventions or disease progress in neurodegenerative diseases. The PSP-QoL is a 45-item, self-administered questionnaire designed to evaluate HR-QoL in PSP.

Methods and Results

Here, the PSP-QoL was translated into Italian and validated in 190 PSP (96 women and 94 men; mean age ± standard deviation, 72 ± 6.5; mean disease duration, 4.2 ± 2.3) patients diagnosed according to the Movement Disorder Society criteria and recruited in 16 third level movement disorders centers participating in the Neurecanet project. The mean PSP-QoL total score was 77.8 ± 37 (physical subscore, 46.5 ± 18.7; mental subscore, 33.6 ± 19.2). The internal consistency was high (Cronbach’s alpha = 0.954); corrected item-total correlation was > 0.40 for the majority of items. The significant and moderate correlation of the PSP-QoL with other HR-QoL measures as well as with motor and disability assessments indicated adequate convergent validity of the scale. Gender and geographic location presented a significant impact on the PSP-QoL in our sample with women and patients from the South of Italy scoring higher than their counterparts.

Conclusion

In conclusion, the Italian version of the PSP-QoL is an easy, reliable and valid tool for assessment of HR-QoL in PSP.
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Metadaten
Titel
Validation of the Italian version of the PSP Quality of Life questionnaire
verfasst von
Marina Picillo
Sofia Cuoco
Marianna Amboni
Francesco Paolo Bonifacio
Fabio Bruschi
Immacolata Carotenuto
Rosa De Micco
Anna De Rosa
Eleonora Del Prete
Francesca Di Biasio
Francesca Elifani
Roberto Erro
Margherita Fabbri
Marika Falla
Giulia Franco
Daniela Frosini
Sebastiano Galantucci
Giulia Lazzeri
Luca Magistrelli
Maria Chiara Malaguti
Anna Vera Milner
Brigida Minafra
Enrica Olivola
Andrea Pilotto
Cristina Rascunà
Maria Cristina Rizzetti
Tommaso Schirinzi
Barbara Borroni
Roberto Ceravolo
Alessio Di Fonzo
Roberta Marchese
Nicola B. Mercuri
Nicola Modugno
Alessandra Nicoletti
Alessandro Padovani
Gabriella Santangelo
Alessandro Stefani
Alessandro Tessitore
Maria Antonietta Volontè
Roberta Zangaglia
Mario Zappia
Maurizio Zibetti
Paolo Barone
Publikationsdatum
26.07.2019
Verlag
Springer International Publishing
Erschienen in
Neurological Sciences / Ausgabe 12/2019
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-019-04010-2

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