Findings
Background
Methods
Patients
Poor ovarian response | Controls | |
---|---|---|
Inclusion-criteria:
| ||
IU of rFSH per day
| 150-200 | 150-200 |
No. of oocytes obtained by oocyte retrieval
| ≤ 3 | 5-13 |
Exclusion-criteria:
| ||
IU of rFSH per day
| < 150 or > 200 | <150 or > 200 |
Age
| > 40 years | > 40 years |
Other
| Polycystic ovary syndrome | As for poor ovarian response. |
Previous adnexal surgery | Present or previous signs of moderate or severe ovarian hyperstimulation syndrome | |
Ovarian endometriosis or other ovarian tumour | ||
Hypogonadism | ||
Ovarian cysts > 3 cm |
Genotyping
Statistics
Results
Characteristic | Poor ovarian response (n = 36) | Controls (n = 98) |
---|---|---|
Age mean (95% CI)
| 34.0b (32.8-35.3) | 32.4 (31.9-32.8) |
BMI (kg/m
2
) mean (95% CI)
| 26.5b (24.3-28.7) | 23.8 (23.1-24.5) |
No. of patients of other ethnicities than Caucasian (%)
| 3 (8.3) | 4 (4.1) |
First time COH (%)
| 32 (88.9) | 83 (84.7) |
Early follicular phase s-FSH
a
mean (95% CI)
| 6.0 (5.3-6.7) | 5.8 (5.4-6.3) |
First dose of rFSH (IU) mean (95% CI)
| 160 (152–168) | 159 (155–162) |
Duration of rFSH medication (Days) mean (95% CI)
| 10.8 (10.2-11.3) | 10.9 (10.8-11.1) |
Total dose of rFSH (IU) mean (95% CI)
| 1739 (1616–1863) | 1738 (1692–1784) |
Oocytes retrieved mean (95% CI)
| 1.5b (1.1-2.0) | 9.0 (8.5-9.5) |
No. of embryos transferred mean (95% CI)
| 0.6b (0.4-0.9) | 1.6 (1.5-1.7) |
Live births (% of started COH)
| 2b (6) | 45 (46) |
No. of patients with v-betaLH (%)
| 4 (11) | 17 (17) |
No. of alleles with v-betaLH (%)
| 4 (6) | 18 (9) |