Skip to main content
Erschienen in: Rheumatology International 2/2016

01.02.2016 | Short Communication - Observational Research

Variation in fatigue may be poorly explained by pain: results from a longitudinal, exploratory study

verfasst von: Anne Christie, Hanne Dagfinrud, Petter Mowinckel, Kåre Birger Hagen

Erschienen in: Rheumatology International | Ausgabe 2/2016

Einloggen, um Zugang zu erhalten

Abstract

It is frequently claimed that fatigue reflects pain and that strategies for alleviating fatigue in patients with ankylosing spondylitis (AS) should focus on pain management. The aim of this study was twofold: to investigate the correlation between fatigue and pain over time and to investigate the temporal relationship between fatigue and pain in patients with AS. Fatigue and pain were assessed twice a week for 35 weeks in 23 patients with AS. Data were reported with text messages on mobile phones, constituting around 70 repeated measurements per patient. To estimate correlation over time, the correlation coefficient within individuals was estimated. When estimating the temporal relationship, we lagged the independent variable and performed individual linear regression. In 16 (70 %) of the patients, ≤36 % of the variance in fatigue was explained by pain. The association between fatigue and pain was synchronous in time in 13 (57 %) patients, while 5 (22 %) patients reported that fatigue precedes pain by 1 week and 5 (22 %) that pain precedes fatigue by 1 week. Fatigue and pain may be two separate and independent symptoms in some patients with AS. The clinical implication is that the two symptoms should be targeted separately because it cannot always be expected that an improvement in one is followed by an improvement in the other.
Literatur
1.
Zurück zum Zitat Hewlett S, Cockshott Z, Byron M, Kitchen K, Tipler S, Pope D et al (2005) Patients’ perceptions of fatigue in rheumatoid arthritis: overwhelming, uncontrollable, ignored. Arthritis Rheum 53(5):697–702CrossRefPubMed Hewlett S, Cockshott Z, Byron M, Kitchen K, Tipler S, Pope D et al (2005) Patients’ perceptions of fatigue in rheumatoid arthritis: overwhelming, uncontrollable, ignored. Arthritis Rheum 53(5):697–702CrossRefPubMed
2.
Zurück zum Zitat Dagfinrud H, Vollestad NK, Loge JH, Kvien TK, Mengshoel AM (2005) Fatigue in patients with ankylosing spondylitis: a comparison with the general population and associations with clinical and self-reported measures. Arthritis Rheum 53(1):5–11CrossRefPubMed Dagfinrud H, Vollestad NK, Loge JH, Kvien TK, Mengshoel AM (2005) Fatigue in patients with ankylosing spondylitis: a comparison with the general population and associations with clinical and self-reported measures. Arthritis Rheum 53(1):5–11CrossRefPubMed
3.
Zurück zum Zitat Brophy S, Davies H, Dennis MS, Cooksey R, Husain MJ, Irvine E, Sibert S (2013) Fatigue in ankylosing spondylitis: treatment should focus on pain management. Semin Arthritis Rheum 42(4):361–367CrossRefPubMed Brophy S, Davies H, Dennis MS, Cooksey R, Husain MJ, Irvine E, Sibert S (2013) Fatigue in ankylosing spondylitis: treatment should focus on pain management. Semin Arthritis Rheum 42(4):361–367CrossRefPubMed
4.
Zurück zum Zitat Repping-Wuts H, Fransen J, van Achterberg T, Bleijenberg G, van Riel P (2007) Persistent severe fatigue in patients with rheumatoid arthritis. J Clin Nurse 16(11c):377–383CrossRef Repping-Wuts H, Fransen J, van Achterberg T, Bleijenberg G, van Riel P (2007) Persistent severe fatigue in patients with rheumatoid arthritis. J Clin Nurse 16(11c):377–383CrossRef
5.
Zurück zum Zitat Zochling J, Braun J (2007) Assessments in ankylosing spondylitis. Best Pract Res Clin Rheumatol 21(4):699–712CrossRefPubMed Zochling J, Braun J (2007) Assessments in ankylosing spondylitis. Best Pract Res Clin Rheumatol 21(4):699–712CrossRefPubMed
6.
Zurück zum Zitat Nikolaus S, Bode C, Taal E, van de Laar MA (2013) Fatigue and factors related to fatigue in rheumatoid arthritis: a systematic review. Arthritis Care Res (Hoboken) 65(7):1128–1146CrossRef Nikolaus S, Bode C, Taal E, van de Laar MA (2013) Fatigue and factors related to fatigue in rheumatoid arthritis: a systematic review. Arthritis Care Res (Hoboken) 65(7):1128–1146CrossRef
7.
Zurück zum Zitat van Tubergen A, Coenen J, Landewe R, Spoorenberg A, Chorus A, Boonen A, van der Linden S, van der Heijde D (2002) Assessment of fatigue in patients with ankylosing spondylitis: a psychometric analysis. Arthritis Rheum 47(1):8–16CrossRefPubMed van Tubergen A, Coenen J, Landewe R, Spoorenberg A, Chorus A, Boonen A, van der Linden S, van der Heijde D (2002) Assessment of fatigue in patients with ankylosing spondylitis: a psychometric analysis. Arthritis Rheum 47(1):8–16CrossRefPubMed
8.
Zurück zum Zitat Pollard LC, Choy EH, Gonzalez J, Khoshaba B, Scott DL (2006) Fatigue in rheumatoid arthritis reflects pain, not disease activity. Rheumatology (Oxford) 45(7):885–889CrossRef Pollard LC, Choy EH, Gonzalez J, Khoshaba B, Scott DL (2006) Fatigue in rheumatoid arthritis reflects pain, not disease activity. Rheumatology (Oxford) 45(7):885–889CrossRef
9.
Zurück zum Zitat van Dartel SA, Repping-Wuts JW, van Hoogmoed D, Bleijenberg G, van Riel PL, Fransen J (2013) Association between fatigue and pain in rheumatoid arthritis: does pain precede fatigue or does fatigue precede pain? Arthritis Care Res (Hoboken) 65(6):862–869CrossRef van Dartel SA, Repping-Wuts JW, van Hoogmoed D, Bleijenberg G, van Riel PL, Fransen J (2013) Association between fatigue and pain in rheumatoid arthritis: does pain precede fatigue or does fatigue precede pain? Arthritis Care Res (Hoboken) 65(6):862–869CrossRef
10.
Zurück zum Zitat Heiberg TMP, Kvien TK, Hagen KB (2009) Patterns of symptom variation: Is level of fatigue independent of pain intensity in patients with rheumatoid arthritis (RA)?. Ann Rheum Dis, EULAR, p 149 Heiberg TMP, Kvien TK, Hagen KB (2009) Patterns of symptom variation: Is level of fatigue independent of pain intensity in patients with rheumatoid arthritis (RA)?. Ann Rheum Dis, EULAR, p 149
11.
Zurück zum Zitat Christie A, Hagen KB, Mowinckel P, Dagfinrud H (2014) Aquatic exercises were associated with an acceptable state of symptoms in patients with inflammatory rheumatic diseases: results from a study with interrupted time-series design. Musculoskelet Care. Des 10. (Epub ahead of print) Christie A, Hagen KB, Mowinckel P, Dagfinrud H (2014) Aquatic exercises were associated with an acceptable state of symptoms in patients with inflammatory rheumatic diseases: results from a study with interrupted time-series design. Musculoskelet Care. Des 10. (Epub ahead of print)
12.
Zurück zum Zitat Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 21(12):2286–2291PubMed Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 21(12):2286–2291PubMed
Metadaten
Titel
Variation in fatigue may be poorly explained by pain: results from a longitudinal, exploratory study
verfasst von
Anne Christie
Hanne Dagfinrud
Petter Mowinckel
Kåre Birger Hagen
Publikationsdatum
01.02.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Rheumatology International / Ausgabe 2/2016
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-015-3357-3

Weitere Artikel der Ausgabe 2/2016

Rheumatology International 2/2016 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.