Background
Methods
Clinical samples
Immunohistochemistry
Histological assessment
Results
Clinicopathological parameters of the study cohort
Case no. | Gender/Age | Etiology | Nodule designation | Size of tumor nodule (mm) | Gradinga
| Growth pattern#
|
---|---|---|---|---|---|---|
1 | M/60 | HBV | i ii | 25 15 | 2 2 | T T |
2 | M/56 | HBV | i ii | 35 30 | 2 2 | T T + A |
3 | M/58 | HBV | i ii iii iv | 50 30 20 10 | 2 2 2 3 | T + A A + T T T |
4 | M/59 | HBV | i ii | 22 18 | 3 2 | T A + T |
5 | M/57 | HCV | i ii | 40 30 | 2 2 | T T |
6 | M/51 | HBV | i ii | 22 10 | 2 2 | T T |
7 | M/66 | HBV | i ii | 63 14 | 2 3 | T T |
8 | M/49 | HBV | i ii iii | 25 20 12 | 2 2 3 | T T T |
9 | M/50 | HCV | i ii | 40 20 | 2 2 | T A + T |
10 | M/65 | HBV | i ii iii | 45 20 15 | 2 2 3 | A + T T T |
11 | M/60 | HBV | i ii | 50 25 | 3 2 | T T |
12 | M/55 | HBV | i ii | 20 10 | 3 2 | T T |
13 | M/58 | HBV | i ii iii | 35 25 20 | 2 2 2 | T T T |
14 | M/46 | HBV | i ii | 20 15 | 2 2 | T T |
15 | M/63 | ALD | i ii iii | 30 25 25 | 3 2 3 | T T T |
16 | M/65 | HCV | i ii | 45 18 | 3 3 | T T |
17 | M/53 | HBV | i ii iii | 20 13 13 | 2 3 2 | T + A T T |
18 | M/53 | HBV | i ii | 34 10 | 2 3 | T + A T |
19 | F/60 | HBV | i ii iii | 40 20 10 | 2 2 2 | T + A T T |
20 | M/63 | HBV | i ii | 45 40 | 2 2 | T T |
21 | F/60 | cryptogenic | i ii | 50 30 | 2 2 | T T |
Immunohistochemical expression of the stemness markers
Case no. | Nodule designation | EpCAM%
| Sox9%
| CK19%
|
---|---|---|---|---|
1 | i ii | 0 0 | 1 0 | 0 0 |
2 | i ii | 0 0 | 0 0 | 0 0 |
3 | i ii iii iv | 1 0 0 0 | 1 1 1 0 | 0 0 1 0 |
4 | i ii | 0 0 | 1 1 | 0 0 |
5 | i ii | 0 0 | 3 1 | 0 0 |
6 | i ii | 0 0 | 3 1 | 0 0 |
7 | i ii | 0 0 | 0 3 | 0 0 |
8 | i ii iii | 0 0 0 | 1 1 2 | 0 0 0 |
9 | i ii | 1 0 | 2 2 | 0 0 |
10 | i ii iii | 0 1 0 | 0 2 1 | 0 1 0 |
11 | i ii | 0 0 | 0 0 | 0 0 |
12 | i ii | 1 0 | 2 1 | 3 0 |
13 | i ii iii | 0 0 0 | 0 0 0 | 0 0 0 |
14 | i ii | 0 0 | 0 1 | 0 1 |
15 | i ii iii | 0 0 0 | 2 1 1 | 0 0 0 |
16 | i ii | 0 0 | 0 1 | 0 0 |
17 | i ii iii | 0 0 0 | 0 1 1 | 0 1 0 |
18 | i ii | 0 0 | 0 0 | 0 0 |
19 | i ii iii | 0 0 0 | 2 0 1 | 1 0 0 |
20 | i ii | 0 0 | 0 0 | 0 0 |
21 | i ii | 0 0 | 0 1 | 0 0 |
Concordance of IHC expression in multi-focal HCC
Correlation of expression pattern and pathological parameters
Sox9 expression in HCC cohort of intra-hepatic metastasis
Case no./Sox9 expression | nodule 1 | nodule 2 | nodule 3 |
---|---|---|---|
22 | 2 | 2 | 2 |
23 | 1 | 1 | 1 |
24 | 3 | 3 | n.a. |
25 | 3 | 3 | n.a. |
26 | 2 | 1 | n.a. |
27 | 1 | 1 | n.a. |