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High Blood Pressure & Cardiovascular Prevention
Erschienen in:

01.06.2019 | Review article

Vascular Aging and Disease of the Small Vessels

verfasst von: Damiano Rizzoni, Marco Rizzoni, Matteo Nardin, Giulia Chiarini, Claudia Agabiti-Rosei, Carlo Aggiusti, Anna Paini, Massimo Salvetti, Maria Lorenza Muiesan

Erschienen in: High Blood Pressure & Cardiovascular Prevention | Ausgabe 3/2019

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Abstract

Cardiovascular events are the consequence of vascular damage at both the macro and microcirculatory level. The relationship between large stiffening artery and microvascular disease may be bidirectional, since wave reflection from microvascular sites could increase systolic blood pressure and pulse pressure, while transmission of increased arterial pulsatility to microvessels could represent a mechanism of damage. Hypertension and aging share similar mechanisms of vascular dysfunction. In fact, vascular remodelling, endothelial dysfunction and vascular stiffness are common features in hypertension and aging. Structural and functional changes in small arteries occur during normal and accelerated aging, possibly triggered by hypertension. A cross-talk may be present between large and small artery changes, interacting with pressure wave transmission and reflection, exaggerating cardiac, brain and kidney damage, and finally leading to cardiovascular and renal complications.
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Metadaten
Titel
Vascular Aging and Disease of the Small Vessels
verfasst von
Damiano Rizzoni
Marco Rizzoni
Matteo Nardin
Giulia Chiarini
Claudia Agabiti-Rosei
Carlo Aggiusti
Anna Paini
Massimo Salvetti
Maria Lorenza Muiesan
Publikationsdatum
01.06.2019
Verlag
Springer International Publishing
Erschienen in
High Blood Pressure & Cardiovascular Prevention / Ausgabe 3/2019
Print ISSN: 1120-9879
Elektronische ISSN: 1179-1985
DOI
https://doi.org/10.1007/s40292-019-00320-w

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