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Angiogenesis

Erschienen in:

07.11.2019 | Review Paper

Vascular co-option in brain metastasis

verfasst von: Pedro García-Gómez, Manuel Valiente

Erschienen in: Angiogenesis | Ausgabe 1/2020

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Abstract

Vascular co-option by brain metastasis-initiating cells has been demonstrated as a critical step in organ colonization. The physical interaction between the cancer cell and the endothelial cell is mediated by integrins and L1CAM and could be involved in aggressive growth but also latency and immune evasion. The key involvement of vascular co-option in brain metastasis has created an emerging field that aims to identify critical targets as well as effective inhibitors with the goal of preventing brain metastases.

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Titel: Vascular co-option in brain metastasis
verfasst von: Pedro García-Gómez
Manuel Valiente
Publikationsdatum: 07.11.2019
Verlag: Springer Netherlands
Erschienen in: Angiogenesis / Ausgabe 1/2020
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-019-09693-x

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