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01.12.2012 | Review | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

Vascular memory: can we broaden the concept of the metabolic memory?

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2012
Autor:
György Jermendy
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-44) contains supplementary material, which is available to authorized users.

Competing interests

The author declares that he has no competing interests.

Author’s contribution

GJ conceived, wrote and approved the final manuscript.

Abstract

Based on the results of recent randomized, controlled clinical trials and analyses of their follow-up periods the concept of metabolic memory cannot be restricted to antihyperglycaemic treatment only, rather it can be extended to lipid-lowering and antihypertensive treatment and even life-style modification. This broadened concept can be designated as vascular memory. According to this new concept, not only immediate and short-term but long-term effects of the metabolic and cardiovascular risk milieu are of great importance. Consequently, early and intensive lifestyle interventions, treatment of hyperglycaemia, lipid abnormalities and hypertension can result in beneficial effects on cardiovascular outcomes even in the long run. On the contrary, failing in target-oriented treatment from early detection of abnormalities can be associated with life-threatening cardiovascular events subsequently. Additional experimental studies are needed to characterize the exact pathomechanism of vascular memory and further clinical trials are also essential to explore its real clinical significance.
Zusatzmaterial
Authors’ original file for figure 1
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Literatur
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