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Allergo Journal
Erschienen in: Allergo Journal 3/2020

08.05.2020 | Systemische Mastozytose | Übersicht

Venom immunotherapy in patients with mastocytosis

verfasst von: David González-de-Olano, Iván Álvarez-Twose, Arantza Vega-Castro

Erschienen in: Allergo Journal | Ausgabe 3/2020

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Abstract

Background: A clear relationship has been demonstrated between hymenoptera venom anaphylaxis (HVA) and primary mast cell activation syndromes (MCAS).
Methods: This review describes the clinical and biological characteristics of patients with primary MCAS who present with HVA, the diagnostic tests that have demonstrated to be useful, and the safety and effectiveness of venom immunotherapy (VIT) in these individuals.
Results: Patients presenting with dizziness or hypotension and without skin involvement after an insect sting are at an increased risk of presenting clonal mast cells (MCs). They usually have low MC burden and highly sensitive techniques are mandatory to reach a final assessment. Skin testing and determinations of specific IgE are useful in detecting patients who are candidates for VIT, which has proved to be safe and effective.
Conclusions: Patients with primary MCAS and IgE-mediated HVA are candidates to receive VIT. Their management does not differ much from general population with the exception of VIT duration.
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Metadaten
Titel
Venom immunotherapy in patients with mastocytosis
verfasst von
David González-de-Olano
Iván Álvarez-Twose
Arantza Vega-Castro
Publikationsdatum
08.05.2020
Verlag
Springer Medizin
Erschienen in
Allergo Journal / Ausgabe 3/2020
Print ISSN: 0941-8849
Elektronische ISSN: 2195-6405
DOI
https://doi.org/10.1007/s15007-020-2514-5

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Anaphylaxie

Es wäre so einfach, ein Leben zu retten – Wenn man nur daran denkt…

Anaphylaxie ist eine akute schwere allergische Reaktion und somit die schwerste Komplikation in der Allergologie. Darauf sollten Ärztinnen und Ärzte vorbereitet sein.

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