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07.02.2023 | Case reports

Ventricular fibrillation and arrhythmia associated with cardiac fibromas involving both ventricles in a 1.5-year-old girl

verfasst von: Daniel Farkaš, Mária Pisarčíková, Peter Vasovčák, Anna Crhová, Alžbeta Ginelliová, Lucia Mistríková, Lucia Fröhlichová, Silvia Farkašová Iannaccone

Erschienen in: Rechtsmedizin | Ausgabe 3/2023

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Abstract

This article reports the autopsy findings of a 1.5-year-old girl with no history of previous hospital admission who suddenly collapsed at home. After 45 minutes of resuscitation efforts, the cardiac activity was restored. During hospitalization, she had ventricular arrhythmia and extremely elevated cardiac troponin levels. Internal examination and immunohistochemistry revealed cardiac fibromas of the right and left ventricles and extensive hypoxic myocardial damage. The right ventricular fibroma demonstrated interdigitating and entrapped myocardium visible at the edges and within the central portion of the tumor. The left ventricular fibroma originated in the subepicardial region and propagated towards the endocardium.

Burke AP, Rosado-de-Christenson M, Templeton PA, Virmani R (1994) Cardiac fibroma: clinicopathologic correlates and surgical treatment. J Thorac Cardiovasc Surg 108:862–870CrossRefPubMed

Williams DB, Danielson GK, McGoon DC, Feldt RH, Edwards WD (1982) Cardiac fibroma: long-term survival after excision. J Thorac Cardiovasc Surg 84:230–236CrossRefPubMed

Engle MA, Ebert PA, Redo SF (1974) Recurrent ventricular tachycardia due to resectable cardiac tumor. Circulation 50:1052–1057CrossRefPubMed

Carreon CK, Sanders SP, Perez-Atayde AR, Del Nido PD, Walsh EP, Geva T, Alexander ME (2019) Interdigitating myocardial tongues in pediatric cardiac fibromas: a plausible substrate for ventricular tachycardia and cardiac arrest. JACC Clin Electrophysiol 5:563–575. https://doi.org/10.1016/j.jacep.2019.01.022CrossRefPubMed

Mecchia D, Lavezzi AM, Matturri L (2013) Primary cardiac fibroma and cardiac conduction system alterations in a case of the sudden death of a 4-month-old infant. Open Cardiovasc Med J 7:47–49. https://doi.org/10.2174/1874192401307010047CrossRefPubMedPubMedCentral

Uzun O, Wilson DG, Vujanic GM, Parsons JM, De Giovanni JV (2007) Cardiac tumors in children. Orphanet J Rare Dis 2:11. https://doi.org/10.1186/1750-1172-2-11CrossRefPubMedPubMedCentral

Luschka H (1855) Ein Fibroid im Herzfleische. Virchows Arch A Pathol Anat Histol 8:343–347CrossRef

Buja LM, Butany J (2015) Cardiovascular pathology. Academic Press, Elsevier, Cambridge

Matějková A, Fabián O (2020) Diferenciální diagnostika tumorózních lézí srdce. Cesk Patol 56:18–25PubMed

10.

Coffin CM (1992) Congenital cardiac fibroma associated with Gorlin syndrome. Pediatr Pathol 12:255–262. https://doi.org/10.3109/15513819209023303CrossRefPubMed

11.

Bartoš V, Kullová M, Adamicová K, Paučinová I (2019) Gorlin-Goltz syndrome. Klin Onkol 32:124–128. https://doi.org/10.14735/amko2019124CrossRefPubMed

12.

Miyake CY, Del Nido PJ, Alexander ME, Cecchin F, Berul CI, Triedman JK, Geva T, Walsh EP (2011) Cardiac tumors and associated arrhythmias in pediatric patients, with observations on surgical therapy for ventricular tachycardia. J Am Coll Cardiol 58:1903–1909. https://doi.org/10.1016/j.jacc.2011.08.005CrossRefPubMed

13.

Geha AS, Weidman WH, Soule EH, McGoon DC (1967) Intramural ventricular cardiac fibroma. Successful removal in two cases and review of the literature. Circulation 36:427–440. https://doi.org/10.1161/01.cir.36.3.427CrossRefPubMed

14.

Colmorn LB, Jensen T, Petersen BL, Helvind M, Jørgensen FS (2012) Prenatal ultrasound diagnosis of a multiple atypical right atrial cardiac fibroma. Ultraschall Med 33:85–86. https://doi.org/10.1055/s-0029-1245552CrossRefPubMed

15.

István K, Törő K, Kardos M, Imre C, György D, Agnes N (2012) Sudden death due to infiltration of left bundle branches by interventricular septal cardiac fibroma. J Forensic Sci 57:1669–1674. https://doi.org/10.1111/j.1556-4029.2012.02255.xCrossRefPubMed

16.

Coppoletta JM, Wolbach SB (1933) Body length and organ weights of infants and children: a study of the body length and normal weights of the more important vital organs of the body between birth and twelve years of age. Am J Pathol 9:55–70PubMedPubMedCentral

17.

Hadravská Š, Dubová M, Miesbauerová M, Mukenšnabl P, Daum O, Mádle A, Smetana K (2017) Hamartom ze zralých kardiomyocytů. Pitevní kazuistika. Cesk Patol 53:185–187PubMed

18.

Otsuka T, Asano K, Murota Y, Fukuda S, Hada Y, Fujii J (1990) Successful removal of a cardiac fibroma in an elderly patient. J Cardiovasc Surg 31:55–57

19.

Yamaguchi M, Hosokawa Y, Ohashi H, Imai M, Oshima Y, Minamiji K (1992) Cardiac fibroma: long-term fate after excision. J Thorac Cardiovasc Surg 103:140–145CrossRefPubMed

20.

Parks FR Jr, Adams F, Longmire WR Jr (1962) Successful excision of a left ventricular hamartoma. Report of a case. Circulation 26:1316–1320. https://doi.org/10.1161/01.CIR.26.6.1316CrossRefPubMed

21.

Jawa DS, Sircar K, Somani R, Grover N, Jaidka S, Singh S (2009) Gorlin-Goltz syndrome. J Oral Maxillofac Pathol 13:89–92. https://doi.org/10.4103/0973-029X.57677CrossRefPubMedPubMedCentral

22.

Lopes NN, Caran EM, Lee ML, Silva NS, Rocha AC, Macedo CR (2010) Gorlin-Goltz syndrome and neoplasms: a case study. J Clin Pediatr Dent 35:203–206. https://doi.org/10.17796/jcpd.35.2.x01248284w166485CrossRefPubMed

Titel: Ventricular fibrillation and arrhythmia associated with cardiac fibromas involving both ventricles in a 1.5-year-old girl
verfasst von: Daniel Farkaš
Mária Pisarčíková
Peter Vasovčák
Anna Crhová
Alžbeta Ginelliová
Lucia Mistríková
Lucia Fröhlichová
Silvia Farkašová Iannaccone
Publikationsdatum: 07.02.2023
Verlag: Springer Medizin
Erschienen in: Rechtsmedizin / Ausgabe 3/2023
Print ISSN: 0937-9819
Elektronische ISSN: 1434-5196
DOI: https://doi.org/10.1007/s00194-023-00615-2

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