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2014 | OriginalPaper | Buchkapitel

9. Verlaufsformen von Epilepsien fokaler Genese

verfasst von : Prof. Dr. B. Neubauer, PD Dr. A. Hahn

Erschienen in: Dooses Epilepsien im Kindes- und Jugendalter

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Unter den Epilepsien mit Anfällen fokaler und multifokaler Genese finden sich weniger als bei Epilepsien mit primär generalisierten Anfällen Verlaufsformen, die als nosographische Einheiten abgegrenzt werden können. Der Verlauf von Epilepsien fokaler Genese zeigt vielmehr eine kaum übersehbare Variabilität. Sie wird in ihrer Gänze erst erkennbar, wenn man langjährige Krankheitsverläufe bei vielen Kindern überblickt. Man kann dann oft einen Wechsel des syndromatischen Charakters beobachten. So kann eine infantile epileptische Enzephalopathie (Ohtahara-Syndrom) in ein West-Syndrom und dieses in ein Lennox-Gastaut-Syndrom übergehen. Ein West- und ein Lennox-Gastaut-Syndrom wiederum können in eine Epilepsie mit komplexen Partialanfällen einmünden. Benigne Partialepilepsien können selten von primär generalisierten Epilepsien abgelöst werden.

Aicardi J, Chevrie JJ (1982) Atypical benign partial epilepsy of childhood. Dev Med Child Neurol 24:281–292CrossRefPubMed

Aicardi J, Goutieres F (1978) Neonatal myoclonic encephalopathy. Rev Electroenceph alogr. Neurophysiol Clin 8:99–101

Arzimanoglou A, French J, Blume WT et al (2009) Lennox- Gastaut syndrome: a consensus approach on diagnosis, assessment, management, and trial methodology. Lancet Neurol 8:82–93CrossRefPubMed

Bali B, Kull LL, Strug LJ et al (2007) Autosomal dominant inheritance of centrotemporal sharp waves in rolandic epilepsy families. Epilepsia 48:2266–2272PubMedPubMedCentral

Barcia G, Fleming MR, Deligniere A et al (2012) De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy. Nat Genet 44:1255–1259CrossRefPubMedPubMedCentral

Bass N, Wyllie E, Comair Y et al (1995) Supplementary sensorimotor area seizures in children and adolescents. J Pediatr 126:537–544CrossRefPubMed

Bast T, Völp A, Wolf C, Rating D; Sulthiame Study Group (2003) The influence of sulthiame on EEG in children with benign childhood epilepsy with centrotemporal spikes (BECTS). Epilepsia 44:215–220CrossRef

Bauer G, Aichner F, Saltuari L (1983) Epilepsies with diffuse slow spikes and waves of late onset. Eur Neurol 22:344–350CrossRefPubMed

Bertrand D, Picard F, Le Hellard S et al (2002) How mutations in the nAChRs can cause ADNFLE epilepsy. Epilepsia 43(Suppl 5):112–122CrossRefPubMed

Bien CG, Elger CE (2008) Epilepsia partialis continua: semiology and differential diagnoses. Epileptic Disord 10:3–7PubMed

Cendes F (2003) Partial epilepsies: overview. Arq Neuropsiquiatr 61(Suppl 1):1–7CrossRefPubMed

Chadwick D, Shukralla A, Marson T (2009) Comparing drug treatments in epilepsy. Ther Adv Neurol Disord 2:181–187CrossRefPubMedPubMedCentral

Coppola G, Plouin P, Chiron C et al (1995) Migrating partial seizures in infancy: a malignant disorder with developmental arrest. Epilepsia 36:1017–1024CrossRefPubMed

Crompton DE, Scheffer IE, Taylor I et al (2010) Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance. Brain 133:3221–3231CrossRefPubMed

Dalla Bernardina B, , Bureau M, , Dravet C et al. (1980) Affective symptoms during attacks of epilepsy in children. Rev Electroencephalogr Neurophysiol Clin 10: 8–18

Darke K, Edwards SW, Hancock E; trial steering committee on behalf of participating investigators (2010) Developmental and epilepsy outcomes at age 4 years in the UKISS trial comparing hormonal treatments to vigabatrin for infantile spasms: a multi-centre randomised trial. Arch Dis Child 95:382–386CrossRefPubMed

Debus OM, Kurlemann G; Study group (2004) Sulthiame in the primary therapy of West syndrome: a randomized double-blind placebo-controlled add-on trial on baseline pyridoxine medication. Epilepsia 45:103–108CrossRef

Deonna T, Roulet-Perez E (2010) Early-onset acquired epileptic aphasia (Landau-Kleffner syndrome, LKS) and regressive autistic disorders with epileptic EEG abnormalities: the continuing debate. Brain Development 32:746–752CrossRefPubMed

De Tiège X, , Goldman S, , Verheulpen D et al. (2006) Coexistence of idiopathic rolandic epilepsy and CSWS in two families. Epilepsia 47: 1723–1727

Doose H (2002) Das EEG bei Epilepsien im Kindes- und Jugend alter. Desitin, Hamburg

Doose H, Baier WK (1989) Benign partial epilepsy and related conditions: multifactorial pathogenesis with hereditary impairment of brain maturation. Eur J Pediatr 149:152–158CrossRefPubMed

Doose H, Brigger-Heuer B, Neubauer B (1997) Children with focal sharp waves: clinical and genetic aspects. Epilepsia 38:788–796CrossRefPubMed

Doose H, Hahn A, Neubauer BA, Pistohl J, Stephani U (2001) Atypical »benign« partial epilepsy of childhood or pseudo- lennox syndrome. Part II: family study. Neuropediatrics 32:9–13CrossRefPubMed

Doose H, Petersen B, Neubauer BA (2002) Occipital sharp waves in idiopathic partial epilepsies - clinical and genetic aspects. Epilepsy Res 48:121–130CrossRefPubMed

Dravet C, Giraud N, Bureau M et al (1986) Benign myoclonus of early infancy or benign non-epileptic infantile spasms. Neuropediatrics 17:33–38CrossRefPubMed

Dulac O Malignant migrating partial seizures in infancy. In: Roger J, Bureau M, Dravet C, Genton P, Tassinari CA, Wolf P (eds) Epileptic syndromes in infancy, childhood and adolescence (3rd edition). John Libbey, London, pp 65–68

Engelsen BA, Tzoulis C, Karlsen B et al (2008) POLG1 mutations cause a syndromic epilepsy with occipital lobe predilection. Brain 131:818–828CrossRefPubMed

Fogarasi A, Jokeit H, Faveret E, Janszky J, Tuxhorn I (2002) The effect of age on seizure semiology in childhood temporal lobe epilepsy. Epilepsia 43:638–643CrossRefPubMed

Fogarasi A, Janszky J, Faveret E, Pieper T, Tuxhorn I (2001) A detailed analysis of frontal lobe seizure semiology in children younger than 7 years. Epilepsia 42:80–85CrossRefPubMed

Frost JD Jr, Hrachovy RA (2005) Pathogenesis of infantile spasms: a model based on developmental desynchronization. J Clin Neurophysiol 22:25–36CrossRefPubMed

Glauser TA (2004) Following catastrophic epilepsy patients from childhood to adulthood. Epilepsia 45(Suppl 5):23–26CrossRefPubMed

Gobbi G, Boni A, Filippini M (2006) The spectrum of idiopathic Rolandic epilepsy syndromes and idiopathic occipital epilepsies: from the benign to the disabling. Epilepsia 47(Suppl 2):62–66CrossRefPubMed

Gobbi G, Bruno L, Pini A, Giovanardi Rossi P, Tassinari CA (1987) Periodic spasms: an unclassified type of epileptic seizure in childhood. Dev Med Child Neurol 29:766–775CrossRefPubMed

Guerrini R (2009) Physiology of epilepsia partialis continua and subcortical mechanisms of status epilepticus. Epilepsia 50(Suppl 12):7–9CrossRefPubMed

Hahn A, Heckel M, Neubauer BA (2007) Pronounced microcephaly in a patient with malignant migrating partial seizures in infancy. Epileptic Disord 9:94–97PubMed

Hahn A, Neubauer BA (2009) Sodium and potassium channel dysfunctions in rare and common idiopathic epilepsy syndromes. Brain Development 31:515–520CrossRefPubMed

Hahn A, Pistohl J, Neubauer BA, Stephani U (2001) Atypical »benign« partial epilepsy or pseudo-Lennox syndrome. Part I: symptomatology and long-term prognosis. Neuropediatrics 32:1–8CrossRefPubMed

Hancock EC, Cross HH (2009) Treatment of Lennox-Gastaut syndrome. Cochrane Database Syst Rev 8:CD00327–7

Hancock EC, Osborne JP, Edwards SW (2008) Treatment of infantile spasms. Cochrane Database Syst Rev 8:CD00327–7

Herlenius E, Heron SE, Grinton BE et al (2007) SCN2A mutations and benign familial neonatal-infantile seizures: the phenotypic spectrum. Epilepsia 48:1138–1142CrossRefPubMed

Hong AM, Turner Z, Hamdy RF, Kossoff EH (2010) Infantile spasms treated with the ketogenic diet: prospective single-center experience in 104 consecutive infants. Epilepsia 51:1403–1407CrossRefPubMed

Hughes JR (2011) A review of the relationships between Landau-Kleffner syndrome, electrical status epilepticus during sleep, and continuous spike-waves during sleep. Epilepsy Behav 20:247–253CrossRefPubMed

Jobst BC, Williamson PD, Thadani VM et al (2010) Intractable occipital lobe epilepsy: clinical characteristics and surgical treatment. Epilepsia 51:2334–2337CrossRefPubMed

Kavros PM, Clarke T, Strug LJ et al (2008) Attention impairment in rolandic epilepsy: systematic review. Epilepsia 49:1570–1580CrossRefPubMed

Kim CH, Chung CK, Lee SK, Lee YK, Chi JG (2004) Parietal lobe epilepsy: surgical treatment and outcome. Stereotact Funct Neurosurg 82:175–185CrossRefPubMed

Kossoff EH, Andermann F (2010) Migraine and epilepsy. Semin Pediatr Neurol 17:117–122CrossRefPubMed

Lagae L (2009) The need for broad spectrum and safe antiepileptic drugs in childhood epilepsy. Acta Neurol Belg 109:167–170PubMed

Lemke, , Lal D, , Reinthaler EM, , Steiner I et al. (2013) Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. Nat Genet 45: 1067–1072

Lerman P, Kivity S (1991) The benign partial nonrolandic epilepsies. J Clin Neurophysiol 8:275–287CrossRefPubMed

Liukkonen E, Kantola-Sorsa E, Paetau R et al (2010) Long-term outcome of 32 children with encephalopathy with status epilepticus during sleep, or ESES syndrome. Epilepsia 51:2023–2032CrossRefPubMed

Lux AL (2007) Is hypsarrhythmia a form of non-convulsive status epilepticus in infants? Acta Neurol Scand 115(Suppl 4):37–44CrossRefPubMed

Lux AL, Edwards SW, Hancock E et al. (2004) The United Kingdom Infantile Spasms Study comparing vigabatrin with prednisolone or tetracosactide at 14 days: a multicentre, randomised controlled trial. Lancet 364: 1773– 1778

Lux AL, Edwards SW, Hancock E; United Kingdom Infantile Spasms Study (2005) The United Kingdom Infantile Spasms Study (UKISS) comparing hormone treatment with vigabatrin on developmental and epilepsy outcomes to age 14 months: a multicentre randomised trial. Lancet Neurol 4:712–717CrossRefPubMed

Marson AG, Appleton R, Baker GA et al. (2007) A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial. Health Technol Assess 11: iii-iv, ix-x, 1–134

Maurer VO, Rizzi M, Bianchetti MG, Ramelli GP (2010) Benign neonatal sleep myoclonus: a review of the literature. Pediatrics 125:e919–e924CrossRefPubMed

Michoulas A, Farrell K (2010) Medical management of Lennox- Gastaut-Syndrome. CNS Drugs 24:363–374CrossRefPubMed

Nabbout R, Dulac O (2008) Epileptic syndromes in infancy and childhood. Curr Opin Neurol 21:161–166CrossRefPubMed

Nakken KO, Røste GK, Hauglie-Hanssen E (2005) Coeliac disease, unilateral occipital calcifications, and drug-resistant epilepsy: successful lesionectomy. Acta Neurol Scand 111:202–204CrossRefPubMed

Neubauer BA, Hahn A, Stephani U, Doose H (2002) Clinical spectrum and genetics of Rolandic epilepsy. Adv Neurol 89:475–479PubMed

Neubauer BA, Fiedler B, Himmelein B et al (1998) Centrotemporal spikes in families with rolandic epilepsy: linkage to chromosome 15q14. Neurology 51:1608–1612CrossRefPubMed

Neubauer BA, Waldegger S, Heinzinger J et al (2008) KCNQ2 and KCNQ3 mutations contribute to different idiopathic epilepsy syn dromes. Neurology 71:177–183CrossRefPubMed

Nickels K, Wirrell E (2008) Electrical status epilepticus in sleep. Semin Pediatr Neurol 15:50–60CrossRefPubMed

Ohtahara S, Yamatogi Y (2006) Ohtahara syndrome: with special reference to its developmental aspects for differentiating from early myoclonic encephalopathy. Epilepsy Res 70(Suppl 1):S58–S67CrossRefPubMed

Okumura A, Watanabe K, Negoro T et al (2006) The clinical characterizations of benign partial epilepsy in infancy. Neuropediatrics 37:359–363CrossRefPubMed

Okumura A, Watanabe K, Negoro T et al (2007) Ictal EEG in benign partial epilepsy in infancy. Pediatr Neurol 36:8–12CrossRefPubMed

Osborne JP, Lux AL, Edwards SW et al (2010) The underlying etiology of infantile spasms (West syndrome): information from the United Kingdom Infantile Spasms Study (UKISS) on contemporary causes and their classification. Epilepsia 51:2168–2174CrossRefPubMed

Overvliet GM, Besseling RM, Vles JS et al (2010) Nocturnal epileptiform EEG discharges, nocturnal epileptic seizures, and language impairments in children: review of the literature. Epilepsy Behav 19:550–558CrossRefPubMed

Patry G, Lyagoubi S, Tassinari CA (1971) Subclinical »electrical status epilepticus« induced by sleep in children. A clinical and electroencephalographic study of six cases. Arch Neurol 24:242–252CrossRefPubMed

Prats JM, Garaizar C, García-Nieto ML, Madoz P (1998) Antiepileptic drugs and atypical evolution of idiopathic partial epilepsy. Pediatr Neurol 18:402–406CrossRefPubMed

Ramelli GP, Donati F, Moser H, Vassella F (1998) Concomitance of childhood absence and Rolandic epilepsy. Clin Electroencephalogr 29:177–180CrossRefPubMed

Ray A, Kotagal P (2005) Temporal lobe epilepsy in children: overview of clinical semiology. Epileptic Disord 7:299–307PubMed

Sakurai K, Tanaka N, Kamada K et al (2007) Magnetoencephalographic studies of focal epileptic activity in three patients with epilepsy suggestive of Lennox-Gastaut syndrome. Epileptic Disord 9:158–163PubMed

Schmitt B (2009) Therapie der Blitz-Nick-Salaam Epilepsie (West-Syndrom) Leitlinie Neuropädiatrie. www.neuropaediatrie.com

Sveinbjornsdottir S, Duncan JS (1993) Parietal and occipital lobe epilepsy: a review. Epilepsia 34:493–521CrossRefPubMed

Talwar D, Baldwin MA, Hutzler R, Griesemer DA (1995) Epileptic spasms in older children: persistence beyond infancy. Epilepsia 36:151–155CrossRefPubMed

Taylor I, Berkovic SF, Kivity S, Scheffer IE (2008) Benign occipital epilepsies of childhood: clinical features and genetics. Brain 131:2287–2294CrossRefPubMed

Vadlamudi L, Kjeldsen MJ, Corey LA et al (2006) Analyzing the etiology of benign rolandic epilepsy: a multicenter twin collaboration. Epilepsia 47:550–555CrossRefPubMed

Verrotti A, D’Adamo E, Parisi P, Chiarelli F, Curatolo P (2010) Levetiracetam in childhood epilepsy. Paediatr Drugs 12:177–186CrossRefPubMed

Verrotti A, Coppola G, Manco R et al (2007) Levetiracetam monotherapy for children and adolescents with benign rolandic seizures. Seizure 16:271–275CrossRefPubMed

Weber YG, Jacob M, Weber G, Lerche H (2008) A BFIS-like syndrome with late onset and febrile seizures: suggestive linkage to chromosome 16p11.2-16q12.1. Epilepsia 49:1959–1964CrossRefPubMed

Wild JM, Chiron C, Ahn H et al (2009) Visual field loss in patients with refractory partial epilepsy treated with vigabatrin: final results from an open-label, observational, multicentre study. CNS Drugs 23:965–982CrossRefPubMed

Woermann FG, Vollmar C (2009) Clinical MRI in children and adults with focal epilepsy: a critical review. Epilepsy Behav 15:40–49CrossRefPubMed

Yamamoto H, Okumura A, Fukuda M (2011) Epilepsies and epileptic syndromes starting in the neonatal period. Brain Development 33:213–220CrossRefPubMed

Titel: Verlaufsformen von Epilepsien fokaler Genese
verfasst von: Prof. Dr. B. Neubauer
PD Dr. A. Hahn
Verlag: Springer Berlin Heidelberg
Buch: Dooses Epilepsien im Kindes- und Jugendalter
Print ISBN: 978-3-642-41953-9

Electronic ISBN: 978-3-642-41954-6

Copyright-Jahr: 2014
DOI: https://doi.org/10.1007/978-3-642-41954-6_9

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