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08.05.2020 | Original Paper

Very late-phase vascular response after everolimus-eluting stent implantation assessed by optical coherence tomography

Zeitschrift:
The International Journal of Cardiovascular Imaging
Autoren:
Amir Kh. M. Khalifa, Yasushi Ino, Takashi Kubo, Takashi Tanimoto, Kunihiro Shimamura, Yasutsugu Shiono, Masahiro Takahata, Kosei Terada, Daisuke Higashioka, Teruaki Wada, Akira Taruya, Hiroki Emori, Yosuke Katayama, Manabu Kashiwagi, Akio Kuroi, Yoshiki Matsuo, Suwako Fujita, Atsushi Tanaka, Takeshi Hozumi, Takashi Akasaka
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Abstract

Long-term safety of second generation drug-eluting stents (DES) has not yet been evaluated. We sought to evaluate the very late phase (> 3 years) vascular response after second generation everolimus-eluting stent (EES) as compared with first generation sirolimus-eluting stent (SES) by using optical coherence tomography (OCT). We examined the vascular response in 39 patients with a total of 55 DESs [31 EESs (mean 54 months after stenting) and 24 first generation SES (mean 66 months after stenting)] by OCT. The frequency of lesions with any malapposed stent struts (19% vs. 46%, p = 0.035) and evagination (6% vs. 42%, p = 0.002) was significantly lower. Segments with malapposed stent struts were significantly shorter (0.4 ± 0.9 mm vs. 1.9 ± 3.5 mm, p = 0.024), maximal malapposition area and malapposition volume were significantly smaller (0.26 ± 0.38 mm2 vs. 0.95 ± 1.54 mm2, p = 0.019, and 0.78 ± 1.35 mm3 vs. 6.22 ± 15.76 mm3, p = 0.016, respectively) in EES. Compared with first generation SES, second generation EES showed more favourable vascular responses at the very late phase.

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