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Archives of Virology

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01.09.2008 | Brief Report

Vimentin is required for dengue virus serotype 2 infection but microtubules are not necessary for this process

verfasst von: Wei Chen, Na Gao, Jia-li Wang, Yan-ping Tian, Zong-tao Chen, Jing An

Erschienen in: Archives of Virology | Ausgabe 9/2008

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Abstract

The present study investigated the effect of microtubules (MTs) and vimentin during dengue virus serotype 2 (DV2) infection. Immunostaining showed that DV2 infection induced MT and vimentin reorganization. Colocalization of DV2 antigens with MTs or vimentin were often observed in ECV304 cells. MT-disrupting agents could enhance DV2 release but did not affect other steps of virus replication. In contrast, disruption of vimentin inhibited DV2 infection. Our results suggest that an MT-dependent mechanism may not be necessary for DV2 infection, and MT disruption may promote DV2 release. However, vimentin is required for DV2 infection.

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Titel: Vimentin is required for dengue virus serotype 2 infection but microtubules are not necessary for this process
verfasst von: Wei Chen
Na Gao
Jia-li Wang
Yan-ping Tian
Zong-tao Chen
Jing An
Publikationsdatum: 01.09.2008
Verlag: Springer Vienna
Erschienen in: Archives of Virology / Ausgabe 9/2008
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-008-0183-x

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