Virchows Archiv

In this issue

• NEWS

The role of the pathologist in the design and conducting of biomarker-driven clinical trials in cancer: position paper of the European Society of Pathology

• Open Access
• REVIEW

Xavier Matias-Guiu, Maria Rosaria Raspollini, Janina Kulka, Ales Ryska, Raed Al Dieri, Peter Schirmacher

Molecular analysis of apocrine mixed tumors and cutaneous myoepitheliomas: a comparative study confirming a continuous spectrum of one entity with near-ubiquitous PLAG1 and rare mutually exclusive HMGA2 gene rearrangements

• Original Article

Boulos Mansour, Michele Donati, Tamás Pancsa, Petr Grossman, Petr Šteiner, Tomáš Vaněček, Kateřina Comová, Michal Michal, Michael Michal

Reducing reflex first-line prescriptions in a surgical pathology laboratory: toward sustainable practice with positive economic and clinical effects

• ORIGINAL ARTICLE

Rémi Vergara, Rudy Chouvel, Béatrice Vergier, Brigitte Le Bail, Marie-Laure Négrier-Leibreich, Geneviève Belleannée, Anne Rullier, Marion Marty

Immunophenotypic analysis of angiomyolipoma with epithelial cysts, comparison to mixed epithelial and stromal tumors and epithelial and stromal elements of normal kidney and ovaries

• ORIGINAL ARTICLE

Irem Kilic, Sheila Segura, Thomas M. Ulbright, Hector Mesa

Heterogeneity of molecular subtyping and therapy-related marker expression in primary tumors and paired lymph node metastases of small cell lung cancer

• ORIGINAL ARTICLE

Yanli Zhu, Wenhao Ren, Sheng Li, Jianghua Wu, Xiao Hu, Haiyue Wang, Kaiwen Chi, Minglei Zhuo, Dongmei Lin

Tumor stroma ratio, tumor stroma maturity, tumor-infiltrating immune cells in relation to prognosis, and neoadjuvant therapy response in esophagogastric junction adenocarcinoma

• ORIGINAL ARTICLE

Na Cheng, Bingzhi Wang, Jiaqi Xu, Liyan Xue, Jianming Ying

Predominance of T-bet-positive Th1 cells in infiltrating T-lymphocytes in most of active arteritis lesions of giant cell arteritis

• ORIGINAL ARTICLE

Hidetoshi Satomi, Mikiko Kobayashi, Ichiro Ito, Koji Asano, Mutsuki Makino, Kenji Kawaguchi, Hiroyuki Kanno

Digital counting of tissue cells for molecular analysis: the QuANTUM pipeline

• Open Access
• ORIGINAL ARTICLE

Vincenzo L’Imperio, Giorgio Cazzaniga, Mauro Mannino, Davide Seminati, Francesco Mascadri, Joranda Ceku, Gabriele Casati, Francesca Bono, Catarina Eloy, Elena Guerini Rocco, Chiara Frascarelli, Matteo Fassan, Umberto Malapelle, Fabio Pagni

Intratumoral heterogeneity of Ki67 proliferation index outperforms conventional immunohistochemistry prognostic factors in estrogen receptor-positive HER2-negative breast cancer

• Original Article

Dovile Zilenaite-Petrulaitiene, Allan Rasmusson, Justinas Besusparis, Ruta Barbora Valkiuniene, Renaldas Augulis, Aida Laurinaviciene, Benoit Plancoulaine, Linas Petkevicius, Arvydas Laurinavicius

Breast tissue imaging atlas using ultra-fast confocal microscopy to identify cancer lesions

• Open Access
• ORIGINAL ARTICLE

Marie-Christine Mathieu, Moira Ragazzi, Malek Ferchiou, Paul J. van Diest, Odile Casiraghi, Aicha Ben Lakhdar, Nizar Labaied, Angelica Conversano, Muriel Abbaci

Esophageal squamous cell carcinoma with pagetoid spread: a clinicopathologic study

• ORIGINAL ARTICLE

Tiffany R. Miller, Xuchen Zhang, Huaibin M. Ko, Stephen M. Lagana, Namrata Setia, Lindsay Yassan, Maria Westerhoff, Vikram Deshpande, Jason L. Hornick, Mark S. Redston, Lei Zhao

Prognostic implications of tumor histology and microenvironment in surgically resected intrahepatic cholangiocarcinoma: a single institutional experience

• ORIGINAL ARTICLE

Irene Y. Chen, Richard F. Dunne, Xiaoyan Liao

The pattern-based interpretation of p53 immunohistochemical expression as a surrogate marker for TP53 mutations in colorectal cancer

• Open Access
• ORIGINAL ARTICLE

Mitsumasa Osakabe, Noriyuki Yamada, Ryo Sugimoto, Noriyuki Uesugi, Eiichi Nakao, Michitaka Honda, Naoki Yanagawa, Tamotsu Sugai

Expression patterns of HNF4α, TTF-1, and SMARCA4 in lung adenocarcinomas: impacts on clinicopathological and genetic features

• Open Access
• ORIGINAL ARTICLE

Hitomi Kawai, Tamaki Miura, Natsumi Kawamatsu, Tomoki Nakagawa, Aya Shiba-Ishii, Taichiro Yoshimoto, Yusuke Amano, Atsushi Kihara, Yuji Sakuma, Kazutaka Fujita, Tomoki Shibano, Shumpei Ishikawa, Tetsuo Ushiku, Masashi Fukayama, Hiroyoshi Tsubochi, Shunsuke Endo, Koichi Hagiwara, Daisuke Matsubara, Toshiro Niki

Ovarian endometrioid carcinoma with a sex cord-like pattern: a morphological, immunohistochemical, and molecular analysis

• Open Access
• ORIGINAL ARTICLE

Antonio Travaglino, Damiano Arciuolo, Angela Santoro, Caterina Fulgione, Alessia Piermattei, Manuela Martinelli, Maria Elisabetta Onori, Angelo Minucci, Antonio Raffone, Frediano Inzani, Gian Franco Zannoni

Beyond histology: A tissue algorithm predictive of post-surgical recurrence in hepatocellular carcinomas, including TERT promoter mutation

• Open Access
• ORIGINAL ARTICLE

Francesco Vasuri, Stefano Chillotti, Thais Maloberti, Elisa Albertini, Giuliana Germinario, Matteo Cescon, Matteo Ravaioli, Dario de Biase, Antonia D’Errico

Nuclear morphological atypia in biopsy accurately reflects the prognosis of myxoid liposarcoma

• ORIGINAL ARTICLE

Kengo Kawaguchi, Kenichi Kohashi, Takeshi Iwasaki, Taro Mori, Hiroshi Furukawa, Chiaki Sato, Hiroki Sonoda, Sakura Shiraishi, Makoto Endo, Yasuharu Nakashima, Yoshinao Oda

Evaluation of the prognostic potential of histopathological subtyping in high-grade serous ovarian carcinoma

• Open Access
• ORIGINAL ARTICLE

Hein S. Zelisse, Robin A. Hwan, Marc J. van de Vijver, Frederike Dijk, Constantijne H. Mom, Gerrit K. J. Hooijer, Mignon D. J. M. van Gent, Malou L. H. Snijders

Comparative epigenomics indicate a common origin of ectopic and intrasellar corticotroph pituitary neuroendocrine tumors/adenomas: a case report

• Open Access
• BRIEF REPORT

Alonso Barrantes-Freer, Max Braune, Benjamin Sandner, Matthias Dottermusch, Dirk Lindner

Sclerosing epithelioid fibrosarcoma: a new mesenchymal non-meningothelial tumor involving the central nervous system?

• BRIEF REPORT

Thibaut Wolf, Victor Sinnes, Damien Reita, Agathe Chammas, Justine Gantzer, Noelle Weingertner, Marie-Pierre Chenard, Julien Todeschi, Chinar Salmanli, Marlène Deschuyter, Georges Noel, Natacha Entz-Werle, Benoît Lhermitte

Myeloid sarcoma with RBM15::MRTFA (MKL1) mimicking vascular neoplasm

• Open Access
• BRIEF REPORT

Fatma Gündoğdu, Abbas Agaimy, Selin Aytaç, Volkan Hazar, Ayşegül Üner, Kemal Kösemehmetoğlu

Clinical significance of location of perineural cancer invasion detected on prostate needle core biopsy

• BRIEF REPORT

Benjamin G. Gertsen, Yuki Teramoto, Ying Wang, Toyonori Tsuzuki, Hiroshi Miyamoto

Correction to: Sclerosing epithelioid fibrosarcoma: a new mesenchymal non-meningothelial tumor involving the central nervous system?

• Correction

Thibaut Wolf, Victor Sinnes, Damien Reita, Agathe Chammas, Justine Gantzer, Noelle Weingertner, Marie-Pierre Chenard, Julien Todeschi, Chinar Salmanli, Marlène Deschuyter, Georges Noel, Natacha Entz-Werle, Benoît Lhermitte

Correction to: Abstracts 

• Correction

Correction to: 34th European Congress of Pathology - Abstracts

• Correction

Correction to: ETV6::ABL1 fusion: from overlooked minor clone in myeloproliferative neoplasm to major player in leukemic transformation

• Open Access
• Correction

Hyun‑Woo Lee, Min‑Seung Park, Boram Kim, Chul Won Jung, Hee‑Jin Kim, Hyun‑Young Kim