Virchows Archiv

In this issue

• NEWS

Massive parallel sequencing of head and neck conventional squamous cell carcinomas: A comprehensive review

• Open Access
• REVIEW

Alfons Nadal, Antonio Cardesa, Abbas Agaimy, Alhadi Almangush, Alessandro Franchi, Henrik Hellquist, Ilmo Leivo, Nina Zidar, Alfio Ferlito

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): what do we need to know?

• REVIEW

Andrés Coca-Pelaz, Juan P. Rodrigo, Abbas Agaimy, Dana M. Hartl, Göran Stenman, Vincent Vander Poorten, Antti A. Mäkitie, Mark Zafereo, Karthik N. Rao, Gregory W. Randolph, Alessandra Rinaldo, Alfio Ferlito

Morphological and immunohistochemical evaluation in distinguishing post-radiotherapy serous-like endometrial change (PoRSEC) and serous endometrial intraepithelial carcinoma (SEIC)

• Open Access
• ORIGINAL ARTICLE

Damiano Arciuolo, Giulia Scaglione, Antonio Travaglino, Nicoletta D’Alessandris, Angela Santoro, Frediano Inzani, Belen Padial Urtueta, Stefania Sfregola, Antonio Raffone, Caterina Fulgione, Michele Valente, Roberta Benvenuto, Federica Cianfrini, Gian Franco Zannoni

EWSR1::ATF1 fusions characterize a group of extra-abdominal epithelioid and round cell mesenchymal neoplasms, phenotypically overlapping with sclerosing epithelioid fibrosarcomas, and intra-abdominal FET::CREB fusion neoplasms

• Open Access
• ORIGINAL ARTICLE

Bharat Rekhi, Josephine K. Dermawan, Karen J. Fritchie, Annette Zimpfer, Tareq M. Mohammad, Fatima S. Ali, Koushik Nandy, Youran Zou, Robert Stoehr, Abbas Agaimy

Extra-abdominal and intra-abdominal FET::CREM fusion mesenchymal neoplasms: comparative clinicopathological study of 9 new cases further supporting a distinct potentially aggressive sarcoma and report of novel sites

• Open Access
• ORIGINAL ARTICLE

Abbas Agaimy, Morgan Blakely, Gerben E. Breimer, Annett Hölsken, Sjors A. Koppes, Norbert Meidenbauer, Johannes A. Rijken, Arno Schad, Adrian G. Simon, Robert Stoehr, Justin A. Bishop, Nasir Ud Din

The challenge of diagnosing neuroendocrine neoplasms: experience from a national reference center

• ORIGINAL ARTICLE

Xixi Zeng, Mengke Ma, Cong Tan, Shujuan Ni, Lei Wang, Meng Zhang, Weiqi Sheng, Shaolei Lu, Dan Huang

Reporting of somatic variants in clinical cancer care: recommendations of the Swiss Society of Molecular Pathology

• Open Access
• ORIGINAL ARTICLE

Yann Christinat, Baptiste Hamelin, Ilaria Alborelli, Paolo Angelino, Valérie Barbié, Bettina Bisig, Heather Dawson, Milo Frattini, Tobias Grob, Wolfram Jochum, Ronny Nienhold, Thomas McKee, Matthias Matter, Edoardo Missiaglia, Francesca Molinari, Sacha Rothschild, Anna Bettina Sobottka-Brillout, Erik Vassella, Martin Zoche, Kirsten D. Mertz

A clinicopathological and molecular series of five TFEB-altered renal cell carcinoma (RCC) cases: highlighting an aggressive subset of TFEB-rearranged RCC concomitant with TFEB amplification/gene copy number gains

• ORIGINAL ARTICLE

Minhua Yan, Ruifen Wang, Wenbin Guan, Ruiqi Jiang, Kezhou Wang, Yi Liu, Lifeng Wang

Molecular characteristics of tubo-ovarian carcinosarcoma at different anatomic locations

• Open Access
• ORIGINAL ARTICLE

Ben Davidson, Arild Holth, Kristina Lindemann, Ane Gerda Zahl Eriksson, Thale Andrea Nilsen, Annette Torgunrud

A potential conundrum in dermatopathology: molecularly confirmed superficial ossifying fibromyxoid tumors with unusual histomorphologic findings and a novel fusion

• ORIGINAL ARTICLE

Antonia Syrnioti, Kyriakos Chatzopoulos, Darcy A. Kerr, Dianne E. Torrence, Meera Hameed, Narasimhan P. Agaram, Cristina Antonescu, Konstantinos Linos

Flanagan’s condensed protocol for neurodegenerative diseases. Implementation in a clinical autopsy setting with partial supervision of a neuropathologist

• ORIGINAL ARTICLE

Aitana López, Samuel López-Muñoz, Gabriela Caballero, Natalia Castrejon, Leonardo Rojo, Nuria Vidal-Robau, Abel Muñoz, Estrella Ortiz, Iván Archilla, Sherley M. Diaz, Ana Belen Larque, Ricardo Lopez del Campo, Daniel Martinez, Natalia Rakislova, Jose Ramirez, Karmele Saez de Gordoa, Esther Sanfeliu, Maite Rodrigo, Adriana García, Miriam Cuatrecasas, Teresa Ribalta, Iban Aldecoa

Endometrial endometrioid adenocarcinoma with a malignant squamous component: is the unusual metastatic pattern unique of these tumors?

• ORIGINAL ARTICLE

M. Ruhul Quddus, Renan Ribeiro e Ribeiro, Jessica B. DiSilvestro, C. James Sung, Kamaljeet Singh

A deep-learning-based model for assessment of autoimmune hepatitis from histology: AI(H)

• Open Access
• ORIGINAL ARTICLE

Caner Ercan, Kattayoun Kordy, Anna Knuuttila, Xiaofei Zhou, Darshan Kumar, Ville Koponen, Peter Mesenbrink, Serenella Eppenberger-Castori, Parisa Amini, Marcos C. Pedrosa, Luigi M. Terracciano

Quantification of Gremlin 1 throughout the tumor stroma using whole slide imaging and its clinicopathological significance in gastric cancer

• ORIGINAL ARTICLE

Takumi Kitaoka, Kenji Harada, Shingo Sakashita, Motohiro Kojima, Tetsuro Taki, Takeshi Kuwata, Takahiro Kinoshita, Mitsuru Futakuchi, Genichiro Ishii, Naoya Sakamoto

Impact of immunohistochemistry staining conditions on the incidence of human epidermal growth factor receptor 2 (HER2)-low breast cancer

• Original Article

Min Chong Kim, Sun Young Kwon, Hye Ra Jung, Young Kyung Bae

Utility of special AT-rich sequence-binding protein 2 (SATB2) immunohistochemistry as a marker for secondary perianal paget disease

• ORIGINAL ARTICLE

Krithika Shenoy, Kathleen Byrnes

Integrating single cell and bulk RNA sequencing data identifies RBM17 as a novel response biomarker for immunotherapy in bladder cancer

• ORIGINAL ARTICLE

Bo Song, Peishan Wu, Chong Wan, Qiangqiang Sun, Guangqi Kong

Colitis associated with persistent drug-induced immune dysregulation

• BRIEF REPORT

Johanna Köhler, Randolf Hammerl, Daniel M. Mayer, Johannes Fessler, Cord Langner

Pseudomyogenic hemangioendothelioma presenting as a penile lesion

• BRIEF REPORT

Reem Youssef, Jessica L. Davis, William J. Anderson, Andres M. Acosta

ETV6::NTRK3-associated papillary adenocarcinoma: let us play it by ear

• BRIEF REPORT

Diana Bell, Ellie Maghami, Rania Bakkar, Michelle Afkhami

Morphological diversity in SDH-deficient renal carcinomas: a three-case exploration of variant features and dedifferentiation

• BRIEF REPORT

Fanni Sánta, Antranik Dabaghian, Boglárka Pósfai, Béla Vasas, László Kaizer, Alex Jenei, Bálint Scheich, Vanda Téglási, Zoltán Sápi, Krisztina Bíró, Anikó Maráz, Mavrogenis Stelios, Henriett Butz, Petr Martínek, Kristýna Pivovarčíková, Zsombor Melegh, Mahmut Akgul, Levente Kuthi

Multifocal vascular neoplasm with an EWSR1::NFATC2 gene fusion and progression to epithelioid angiosarcoma – a case report

• BRIEF REPORT

Jože Pižem, Emanuela Boštjančič, Andrej Zupan, Vladka Salapura, Blaž Mavčič, Ana Blatnik, Olga Blatnik, Mojca Unk, Izidor Kern, Miha Švarc, Alenka Matjašič