Skip to main content
Erschienen in:

09.11.2021 | Original Article

Virus-induced FoxO factor facilitates replication of human cytomegalovirus

verfasst von: Sirwan Sleman

Erschienen in: Archives of Virology | Ausgabe 1/2022

Einloggen, um Zugang zu erhalten

Abstract

Recently, it was reported that the forkhead box O (FoxO) transcription factor promotes human cytomegalovirus (HCMV) replication via direct binding to the promoters of the major immediate-early (MIE) genes, but how the FoxO factor impacts HCMV replication remains unknown. Here, it is reported that FoxO1 expression is strongly induced by HCMV infection in cells of fibroblast origin. Suppression of the FoxO1 gene by specific RNA interference significantly inhibited HCMV growth and replication, but viral DNA synthesis was not affected considerably. Interestingly, depletion or overexpression of FoxO1 had a significant effect on the expression of viral early/late transcripts. FoxO1 was found to colocalize with the pUL44 protein subunit of viral replication compartments without direct association with DNA. This study highlights how FoxO enhances HCMV gene transcription and viral replication to promote infection.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Mocarski ES Jr, Shenk T, Pass RF (2007) Cytomegaloviruses. Fields Virol II:2701–2772 Mocarski ES Jr, Shenk T, Pass RF (2007) Cytomegaloviruses. Fields Virol II:2701–2772
2.
Zurück zum Zitat Crumpacker CS (2015) Cytomegalovirus (CMV). In: Bennett J, Dolin R, Blaser M (eds) Bennett’s principles and practice of infectious diseases, 8th edn. Saunders, New York, pp 1738-1753.e4 Crumpacker CS (2015) Cytomegalovirus (CMV). In: Bennett J, Dolin R, Blaser M (eds) Bennett’s principles and practice of infectious diseases, 8th edn. Saunders, New York, pp 1738-1753.e4
3.
Zurück zum Zitat Fehr AR, Yu D (2013) Control the host cell cycle: viral regulation of the anaphase-promoting complex. J Virol 87:8818–8825PubMedPubMedCentral Fehr AR, Yu D (2013) Control the host cell cycle: viral regulation of the anaphase-promoting complex. J Virol 87:8818–8825PubMedPubMedCentral
4.
Zurück zum Zitat Sanchez V, Spector DH (2008) Subversion of cell cycle regulatory pathways. Curr Top Microbiol Immunol 325:243–262PubMed Sanchez V, Spector DH (2008) Subversion of cell cycle regulatory pathways. Curr Top Microbiol Immunol 325:243–262PubMed
5.
Zurück zum Zitat Yu Y, Pierciey FJ Jr, Maguire TG, Alwine JC (2013) PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection. PLoS Pathog 9:e1003266PubMedPubMedCentral Yu Y, Pierciey FJ Jr, Maguire TG, Alwine JC (2013) PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection. PLoS Pathog 9:e1003266PubMedPubMedCentral
6.
Zurück zum Zitat Yu Y, Maguire TG, Alwine JC (2014) ChREBP, a glucose-responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus-infected cells. Proc Natl Acad Sci USA 111:1951–1956PubMedPubMedCentral Yu Y, Maguire TG, Alwine JC (2014) ChREBP, a glucose-responsive transcriptional factor, enhances glucose metabolism to support biosynthesis in human cytomegalovirus-infected cells. Proc Natl Acad Sci USA 111:1951–1956PubMedPubMedCentral
7.
Zurück zum Zitat Yu Y, Clippinger AJ, Alwine JC (2011) Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection. Trends Microbiol 19:360–367PubMedPubMedCentral Yu Y, Clippinger AJ, Alwine JC (2011) Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection. Trends Microbiol 19:360–367PubMedPubMedCentral
8.
Zurück zum Zitat Munger J, Bennett BD, Parikh A, Feng XJ, McArdle J, Rabitz HA, Shenk T, Rabinowitz JD (2008) Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat Biotechnol 26:1179–1186PubMedPubMedCentral Munger J, Bennett BD, Parikh A, Feng XJ, McArdle J, Rabitz HA, Shenk T, Rabinowitz JD (2008) Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy. Nat Biotechnol 26:1179–1186PubMedPubMedCentral
9.
Zurück zum Zitat Munger J, Bajad SU, Coller HA, Shenk T, Rabinowitz JD (2006) Dynamics of the cellular metabolome during human cytomegalovirus infection. PLoS Pathog 2:e132PubMedPubMedCentral Munger J, Bajad SU, Coller HA, Shenk T, Rabinowitz JD (2006) Dynamics of the cellular metabolome during human cytomegalovirus infection. PLoS Pathog 2:e132PubMedPubMedCentral
10.
Zurück zum Zitat DeVito SR, Ortiz-Riano E, Martinez-Sobrido L, Munger J (2014) Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation. Proc Natl Acad Sci USA 111:18019–18024PubMedPubMedCentral DeVito SR, Ortiz-Riano E, Martinez-Sobrido L, Munger J (2014) Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation. Proc Natl Acad Sci USA 111:18019–18024PubMedPubMedCentral
11.
Zurück zum Zitat Buchkovich NJ, Yu Y, Zampieri CA, Alwine JC (2008) The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nat Rev Microbiol 6:266–275PubMedPubMedCentral Buchkovich NJ, Yu Y, Zampieri CA, Alwine JC (2008) The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nat Rev Microbiol 6:266–275PubMedPubMedCentral
12.
Zurück zum Zitat Clippinger AJ, Alwine JC (2012) Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells. Genes Dev 26:2015–2026PubMedPubMedCentral Clippinger AJ, Alwine JC (2012) Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells. Genes Dev 26:2015–2026PubMedPubMedCentral
13.
Zurück zum Zitat Clippinger AJ, Maguire TG, Alwine JC (2011) Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation. J Virol 85:9369–9376PubMedPubMedCentral Clippinger AJ, Maguire TG, Alwine JC (2011) Human cytomegalovirus infection maintains mTOR activity and its perinuclear localization during amino acid deprivation. J Virol 85:9369–9376PubMedPubMedCentral
14.
Zurück zum Zitat Clippinger AJ, Maguire TG, Alwine JC (2011) The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection. J Virol 85:3930–3939PubMedPubMedCentral Clippinger AJ, Maguire TG, Alwine JC (2011) The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection. J Virol 85:3930–3939PubMedPubMedCentral
15.
Zurück zum Zitat Tilton C, Clippinger AJ, Maguire T, Alwine JC (2011) Human cytomegalovirus induces multiple means to combat reactive oxygen species. J Virol 85:12585–12593PubMedPubMedCentral Tilton C, Clippinger AJ, Maguire T, Alwine JC (2011) Human cytomegalovirus induces multiple means to combat reactive oxygen species. J Virol 85:12585–12593PubMedPubMedCentral
16.
Zurück zum Zitat Alwine JC (2008) Modulation of host cell stress responses by human cytomegalovirus. Curr Top Microbiol Immunol 325:263–279PubMed Alwine JC (2008) Modulation of host cell stress responses by human cytomegalovirus. Curr Top Microbiol Immunol 325:263–279PubMed
17.
Zurück zum Zitat Qian Z, Xuan B, Gualberto N, Yu D (2011) The human cytomegalovirus protein pUL38 suppresses endoplasmic reticulum stress-mediated cell death independently of its ability to induce mTORC1 activation. J Virol 85:9103–9113PubMedPubMedCentral Qian Z, Xuan B, Gualberto N, Yu D (2011) The human cytomegalovirus protein pUL38 suppresses endoplasmic reticulum stress-mediated cell death independently of its ability to induce mTORC1 activation. J Virol 85:9103–9113PubMedPubMedCentral
18.
Zurück zum Zitat Terhune S, Torigoi E, Moorman N, Silva M, Qian Z, Shenk T, Yu D (2007) Human cytomegalovirus UL38 protein blocks apoptosis. J Virol 81:3109–3123PubMedPubMedCentral Terhune S, Torigoi E, Moorman N, Silva M, Qian Z, Shenk T, Yu D (2007) Human cytomegalovirus UL38 protein blocks apoptosis. J Virol 81:3109–3123PubMedPubMedCentral
19.
Zurück zum Zitat Eijkelenboom A, Burgering BM (2013) FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol 14:83–97PubMed Eijkelenboom A, Burgering BM (2013) FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol 14:83–97PubMed
20.
Zurück zum Zitat Lam EW, Brosens JJ, Gomes AR, Koo CY (2013) Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer 13:482–495PubMed Lam EW, Brosens JJ, Gomes AR, Koo CY (2013) Forkhead box proteins: tuning forks for transcriptional harmony. Nat Rev Cancer 13:482–495PubMed
21.
Zurück zum Zitat Webb AE, Kundaje A, Brunet A (2016) Characterization of the direct targets of FOXO transcription factors throughout evolution. Aging Cell 15(4):673–685PubMedPubMedCentral Webb AE, Kundaje A, Brunet A (2016) Characterization of the direct targets of FOXO transcription factors throughout evolution. Aging Cell 15(4):673–685PubMedPubMedCentral
22.
Zurück zum Zitat Tzivion G, Dobson M, Ramakrishnan G (2011) FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. Biochim Biophys Acta 1813:1938–1945PubMed Tzivion G, Dobson M, Ramakrishnan G (2011) FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. Biochim Biophys Acta 1813:1938–1945PubMed
23.
Zurück zum Zitat Hay N (2011) Interplay between FOXO, TOR, and Akt. Biochem Biophys Acta 1813(11):1965–1970PubMed Hay N (2011) Interplay between FOXO, TOR, and Akt. Biochem Biophys Acta 1813(11):1965–1970PubMed
24.
Zurück zum Zitat Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL, Burgering BM (2004) FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 23:4802–4812PubMedPubMedCentral Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL, Burgering BM (2004) FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 23:4802–4812PubMedPubMedCentral
25.
Zurück zum Zitat Yuan Z, Lehtinen MK, Merlo P, Villén J, Gygi S, Bonni A (2009) Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem 284(17):11285–11292PubMedPubMedCentral Yuan Z, Lehtinen MK, Merlo P, Villén J, Gygi S, Bonni A (2009) Regulation of neuronal cell death by MST1-FOXO1 signaling. J Biol Chem 284(17):11285–11292PubMedPubMedCentral
26.
Zurück zum Zitat Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, Becker EBE, DiBacco S, de la Iglesia N, Gygi SP, Blackwell TK, Bonni A (2006) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125:987–1001PubMed Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, Becker EBE, DiBacco S, de la Iglesia N, Gygi SP, Blackwell TK, Bonni A (2006) A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 125:987–1001PubMed
27.
Zurück zum Zitat Calnan DR, Brunet A (2008) The FoxO code. Oncogene 27:2276–2288PubMed Calnan DR, Brunet A (2008) The FoxO code. Oncogene 27:2276–2288PubMed
28.
Zurück zum Zitat Munoz-Fontela C, Marcos-Villar L, Gallego P, Arroyo J, Da Costa M, Pomeranz KM, Lam EW, Rivas C (2007) Latent protein LANA2 from Kaposi’s sarcoma-associated herpesvirus interacts with 14-3-3 proteins and inhibits FOXO3a transcription factor. J Virol 81:1511–1516PubMed Munoz-Fontela C, Marcos-Villar L, Gallego P, Arroyo J, Da Costa M, Pomeranz KM, Lam EW, Rivas C (2007) Latent protein LANA2 from Kaposi’s sarcoma-associated herpesvirus interacts with 14-3-3 proteins and inhibits FOXO3a transcription factor. J Virol 81:1511–1516PubMed
29.
Zurück zum Zitat Chen YR, Liu MT, Chang YT, Wu CC, Hu CY, Chen JY (2008) Epstein-Barr virus latent membrane protein 1 represses DNA repair through the PI3K/Akt/FOXO3a pathway in human epithelial cells. J Virol 82:8124–8137PubMedPubMedCentral Chen YR, Liu MT, Chang YT, Wu CC, Hu CY, Chen JY (2008) Epstein-Barr virus latent membrane protein 1 represses DNA repair through the PI3K/Akt/FOXO3a pathway in human epithelial cells. J Virol 82:8124–8137PubMedPubMedCentral
30.
Zurück zum Zitat Deng L, Shoji I, Ogawa W, Kaneda S, Soga T, Jiang DP, Ide YH, Hotta H (2011) Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway. J Virol 85:8556–8568PubMedPubMedCentral Deng L, Shoji I, Ogawa W, Kaneda S, Soga T, Jiang DP, Ide YH, Hotta H (2011) Hepatitis C virus infection promotes hepatic gluconeogenesis through an NS5A-mediated, FoxO1-dependent pathway. J Virol 85:8556–8568PubMedPubMedCentral
31.
Zurück zum Zitat Oteiza A, Mechti N (2011) The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasome. J Virol 85:6480–6491PubMedPubMedCentral Oteiza A, Mechti N (2011) The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasome. J Virol 85:6480–6491PubMedPubMedCentral
32.
Zurück zum Zitat van Grevenynghe J, Procopio FA, He Z, Chomont N, Riou C, Zhang Y et al (2008) Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection. Nat Med 14:266–274PubMed van Grevenynghe J, Procopio FA, He Z, Chomont N, Riou C, Zhang Y et al (2008) Transcription factor FOXO3a controls the persistence of memory CD4(+) T cells during HIV infection. Nat Med 14:266–274PubMed
33.
Zurück zum Zitat Cui M, Huang Y, Zhao Y, Zheng J (2009) New insights for FOXO and cell-fate decision in HIV infection and HIV associated neurocognitive disorder. Adv Exp Med Biol 665:143–159PubMedPubMedCentral Cui M, Huang Y, Zhao Y, Zheng J (2009) New insights for FOXO and cell-fate decision in HIV infection and HIV associated neurocognitive disorder. Adv Exp Med Biol 665:143–159PubMedPubMedCentral
34.
Zurück zum Zitat Kino T, De Martino MU, Charmandari E, Ichijo T, Outas T, Chrousos GP (2005) HIV-1 accessory protein Vpr inhibits the effect of insulin on the FoxO subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients. Diabetes 54:23–31PubMed Kino T, De Martino MU, Charmandari E, Ichijo T, Outas T, Chrousos GP (2005) HIV-1 accessory protein Vpr inhibits the effect of insulin on the FoxO subfamily of forkhead transcription factors by interfering with their binding to 14-3-3 proteins: potential clinical implications regarding the insulin resistance of HIV-1-infected patients. Diabetes 54:23–31PubMed
35.
Zurück zum Zitat Wilk A, Urbanska K, Yang S, Wang JY, Amini S, Del Valle L, Peruzzi F, Meggs L, Reiss K (2011) Insulin-like growth factor-I-forkhead box O transcription factor 3a counteracts high glucose/tumor necrosis factor-alpha-mediated neuronal damage: implications for human immunodeficiency virus encephalitis. J Neurosci Res 89:183–198PubMed Wilk A, Urbanska K, Yang S, Wang JY, Amini S, Del Valle L, Peruzzi F, Meggs L, Reiss K (2011) Insulin-like growth factor-I-forkhead box O transcription factor 3a counteracts high glucose/tumor necrosis factor-alpha-mediated neuronal damage: implications for human immunodeficiency virus encephalitis. J Neurosci Res 89:183–198PubMed
36.
Zurück zum Zitat Zhang S, Liu L, Wang R, Tuo H, Guo Y, Yi L, Wang D, Wang J (2013) MicroRNA-217 promotes the angiogenesis of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and FOXO3A. PLoS ONE 8:e83620PubMedPubMedCentral Zhang S, Liu L, Wang R, Tuo H, Guo Y, Yi L, Wang D, Wang J (2013) MicroRNA-217 promotes the angiogenesis of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and FOXO3A. PLoS ONE 8:e83620PubMedPubMedCentral
38.
Zurück zum Zitat Hale AE, Collins-McMillen D, Lenarcic EM et al (2020) FOXO transcription factors activate alternative major immediate-early promoters to induce human cytomegalovirus reactivation. PNAS 117(31):18764–18770PubMedPubMedCentral Hale AE, Collins-McMillen D, Lenarcic EM et al (2020) FOXO transcription factors activate alternative major immediate-early promoters to induce human cytomegalovirus reactivation. PNAS 117(31):18764–18770PubMedPubMedCentral
39.
Zurück zum Zitat Harada Y, Elly C, Ying G, Paik JH, DePinho RA, Liu YC (2010) Transcription factors FoxO3a and FoxO1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med 207:1381–1391PubMedPubMedCentral Harada Y, Elly C, Ying G, Paik JH, DePinho RA, Liu YC (2010) Transcription factors FoxO3a and FoxO1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med 207:1381–1391PubMedPubMedCentral
40.
Zurück zum Zitat Qian Z, Leung-Pineda V, Xuan B, Piwnica-Worms H, Yu D (2010) Human cytomegalovirus protein pUL117 tar (Baar MP, 2017) gets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. PLoS Pathog 6:e1000814PubMedPubMedCentral Qian Z, Leung-Pineda V, Xuan B, Piwnica-Worms H, Yu D (2010) Human cytomegalovirus protein pUL117 tar (Baar MP, 2017) gets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis. PLoS Pathog 6:e1000814PubMedPubMedCentral
41.
Zurück zum Zitat Everett RD, Boutell C, McNair C, Grant L, Orr A (2010) Comparison of the biological and biochemical activities of several members of the alphaherpesvirus ICP0 family of proteins. J Virol 84:3476–3487PubMedPubMedCentral Everett RD, Boutell C, McNair C, Grant L, Orr A (2010) Comparison of the biological and biochemical activities of several members of the alphaherpesvirus ICP0 family of proteins. J Virol 84:3476–3487PubMedPubMedCentral
42.
Zurück zum Zitat Boussif O et al (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 92:7297–7301PubMedPubMedCentral Boussif O et al (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 92:7297–7301PubMedPubMedCentral
43.
Zurück zum Zitat Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D (2012) Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. PLoS Pathog 8:e1002789PubMedPubMedCentral Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D (2012) Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. PLoS Pathog 8:e1002789PubMedPubMedCentral
44.
Zurück zum Zitat Nakae J, Kitamura T, Silver DL, Accili D (2001) The forkhead transcription factor FoxO1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest 108:1359–1367PubMedPubMedCentral Nakae J, Kitamura T, Silver DL, Accili D (2001) The forkhead transcription factor FoxO1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest 108:1359–1367PubMedPubMedCentral
45.
Zurück zum Zitat Yu D, Smith GA, Enquist LW, Shenk T (2002) Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene. J Virol 76:2316–2328PubMedPubMedCentral Yu D, Smith GA, Enquist LW, Shenk T (2002) Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene. J Virol 76:2316–2328PubMedPubMedCentral
46.
Zurück zum Zitat Xuan B, Qian Z, Torigoi E, Yu D (2009) Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death. J Virol 83:3463–3474PubMedPubMedCentral Xuan B, Qian Z, Torigoi E, Yu D (2009) Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death. J Virol 83:3463–3474PubMedPubMedCentral
47.
Zurück zum Zitat Nelson J, Denisenko O, Bomsztyk K (2006) Protocol for the fast chromatin immunoprecipitation (ChIP) method. Nat Protoc 1:179–185PubMed Nelson J, Denisenko O, Bomsztyk K (2006) Protocol for the fast chromatin immunoprecipitation (ChIP) method. Nat Protoc 1:179–185PubMed
48.
Zurück zum Zitat Yalley A, Schill D, Hatta M, Johnson N, Cirillo LA (2016) Loss of interdependent binding by the FoxO1 and FoxA1/A2 forkhead transcription factors culminates in perturbation of active chromatin marks and binding of transcriptional regulators at insulin-sensitive genes. J Biol Chem 291:8848–8861PubMedPubMedCentral Yalley A, Schill D, Hatta M, Johnson N, Cirillo LA (2016) Loss of interdependent binding by the FoxO1 and FoxA1/A2 forkhead transcription factors culminates in perturbation of active chromatin marks and binding of transcriptional regulators at insulin-sensitive genes. J Biol Chem 291:8848–8861PubMedPubMedCentral
49.
Zurück zum Zitat Nakamura M, Takakura M, Fujii R, Maida Y, Bono Y, Mizumoto Y, Zhang X, Kiyono T, Kyo S (2013) The PRB-dependent FOXO1/IGFBP-1 axis is essential for progestin to inhibit endometrial epithelial growth. Cancer Lett 336(1):68–75PubMed Nakamura M, Takakura M, Fujii R, Maida Y, Bono Y, Mizumoto Y, Zhang X, Kiyono T, Kyo S (2013) The PRB-dependent FOXO1/IGFBP-1 axis is essential for progestin to inhibit endometrial epithelial growth. Cancer Lett 336(1):68–75PubMed
50.
Zurück zum Zitat Hatta M, Cirillo LA (2007) Chromatin opening and stable perturbation of core histone:DNA contacts by FoxO1. J Biol Chem 282(49):35583–35593PubMed Hatta M, Cirillo LA (2007) Chromatin opening and stable perturbation of core histone:DNA contacts by FoxO1. J Biol Chem 282(49):35583–35593PubMed
51.
Zurück zum Zitat Schill D, Nord J, Cirillo LA (2019) FoxO1 and FoxA1/2 form a complex on DNA and cooperate to open chromatin at insulin-regulated genes FoxO1 and FoxA1/2 form a complex on DNA and cooperate to open chromatin at insulin-regulated genes. Biochem Cell Biol 97(2):118–129PubMed Schill D, Nord J, Cirillo LA (2019) FoxO1 and FoxA1/2 form a complex on DNA and cooperate to open chromatin at insulin-regulated genes FoxO1 and FoxA1/2 form a complex on DNA and cooperate to open chromatin at insulin-regulated genes. Biochem Cell Biol 97(2):118–129PubMed
52.
Zurück zum Zitat Perng YC, Qian Z, Fehr AR, Xuan B, Yu D (2011) The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts. J Virol 85:4841–4852PubMedPubMedCentral Perng YC, Qian Z, Fehr AR, Xuan B, Yu D (2011) The human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts. J Virol 85:4841–4852PubMedPubMedCentral
53.
Zurück zum Zitat Quinlan MP, Chen LB, Knipe DM (1984) The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication. Cell 36:857–868PubMed Quinlan MP, Chen LB, Knipe DM (1984) The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication. Cell 36:857–868PubMed
54.
Zurück zum Zitat Penfold ME, Mocarski ES (1997) Formation of cytomegalovirus DNA replication compartments defined by localization of viral proteins and DNA synthesis. Virology 239:46–61PubMed Penfold ME, Mocarski ES (1997) Formation of cytomegalovirus DNA replication compartments defined by localization of viral proteins and DNA synthesis. Virology 239:46–61PubMed
55.
Zurück zum Zitat Taylor TJ, Knipe DM (2004) Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8. J Virol 78:5856–5866PubMedPubMedCentral Taylor TJ, Knipe DM (2004) Proteomics of herpes simplex virus replication compartments: association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8. J Virol 78:5856–5866PubMedPubMedCentral
56.
Zurück zum Zitat Qian Z, Xuan B, Hong TT, Yu D (2008) The full-length protein encoded by human cytomegalovirus gene UL117 is required for the proper maturation of viral replication compartments. J Virol 82:3452–3465PubMedPubMedCentral Qian Z, Xuan B, Hong TT, Yu D (2008) The full-length protein encoded by human cytomegalovirus gene UL117 is required for the proper maturation of viral replication compartments. J Virol 82:3452–3465PubMedPubMedCentral
57.
Zurück zum Zitat Isomura H, Stinski MF, Kudoh A et al (2007) The late promoter of the human cytomegalovirus viral DNA polymerase processivity factor has an impact on delayed early and late viral gene products but not on viral DNA synthesis. J Virol 81(12):6197–6206PubMedPubMedCentral Isomura H, Stinski MF, Kudoh A et al (2007) The late promoter of the human cytomegalovirus viral DNA polymerase processivity factor has an impact on delayed early and late viral gene products but not on viral DNA synthesis. J Virol 81(12):6197–6206PubMedPubMedCentral
58.
Zurück zum Zitat Isomura H, Stinski MF, Kudoh A, Murata T, Nakayama S, Sato Y, Iwahori S, Tsurumi T (2008) Noncanonical TATA sequence in the UL44 late promoter of human cytomegalovirus is required for the accumulation of late viral transcripts. J Virol 82(4):1638–1646PubMed Isomura H, Stinski MF, Kudoh A, Murata T, Nakayama S, Sato Y, Iwahori S, Tsurumi T (2008) Noncanonical TATA sequence in the UL44 late promoter of human cytomegalovirus is required for the accumulation of late viral transcripts. J Virol 82(4):1638–1646PubMed
59.
Zurück zum Zitat Nevels M, Paulus C, Shenk T (2004) Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation. PNAS 101(49):17234–17239PubMedPubMedCentral Nevels M, Paulus C, Shenk T (2004) Human cytomegalovirus immediate-early 1 protein facilitates viral replication by antagonizing histone deacetylation. PNAS 101(49):17234–17239PubMedPubMedCentral
Metadaten
Titel
Virus-induced FoxO factor facilitates replication of human cytomegalovirus
verfasst von
Sirwan Sleman
Publikationsdatum
09.11.2021
Verlag
Springer Vienna
Erschienen in
Archives of Virology / Ausgabe 1/2022
Print ISSN: 0304-8608
Elektronische ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-021-05279-5

Kompaktes Leitlinien-Wissen Innere Medizin (Link öffnet in neuem Fenster)

Mit medbee Pocketcards schnell und sicher entscheiden.
Leitlinien-Wissen kostenlos und immer griffbereit auf ihrem Desktop, Handy oder Tablet.

Neu im Fachgebiet Innere Medizin

Vorhofflimmern: Antikoagulation vor Schlaganfall von Vorteil

Erleiden Menschen mit Vorhofflimmern einen ischämischen Schlaganfall, ist dieser weniger schwer, auch sind Infarktgröße und Blutungsrisiko geringer, wenn sie zuvor orale Antikoagulanzien erhalten haben. Die Art der Antikoagulation spielt dabei keine Rolle.

HCL-Systeme bei Typ-1-Diabetes: Blutzuckerkontrolle besser, Risiko für Ketoazidose aber höher

Eine bessere Blutzuckerkontrolle und weniger Fälle von hypoglykämischem Koma, dafür mehr diabetische Ketoazidosen. Dieses HCL-Insulin-Therapie-Profil zeigte sich in einem Vergleich von Hybrid-Closed-Loop(HCL)- und Open-Loop-Systemen bei Typ-I-Diabetes im DPV-Register.

Kein (großer) Schutz vor Kolorektalkarzinom-Rezidiven durch ASS

Die erste Phase-3-Studie zum Nutzen von ASS in der adjuvanten Therapie des kolorektalen Karzinoms ist negativ verlaufen. Das abschließende Urteil über eine Sekundärprävention mit ASS ist trotzdem noch nicht gefallen.

Möglicher Zusatzeffekt von SGLT-2-Hemmern und GLP-1-Analoga bei COPD

Menschen mit Typ-2-Diabetes, die gleichzeitig an COPD leiden, könnten von der Behandlung mit SGLT-2-Hemmern und GLP-1-Rezeptoragonisten doppelt profitieren: Eine Analyse aus den USA deutet auf ein vermindertes Exazerbationsrisiko hin.

EKG Essentials: EKG befunden mit System (Link öffnet in neuem Fenster)

In diesem CME-Kurs können Sie Ihr Wissen zur EKG-Befundung anhand von zwölf Video-Tutorials auffrischen und 10 CME-Punkte sammeln.
Praxisnah, relevant und mit vielen Tipps & Tricks vom Profi.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.