Background
Methods
Subjects
Clinical assessment
Evaluation of body composition
Laboratory analysis
Biological and inflammatory parameters
Carotid IMT measurements
Statistical analysis
Results
Baseline
Patient characteristics, body composition by DXA and metabolic parameters.
Without Lipodystrophy defined by FMR | With Lipodystrophy defined by FMR |
P
| |
---|---|---|---|
n (%) | 64 | 51 | – |
Gender [n(%)] | |||
Male | 49 (76.6%) | 42(82.4%) | 0.448 |
Female | 15(23.4%) | 9(17.6%) | |
Age [years, mean (sd)] | 45 (12.2) | 49(9.9) | 0.052 |
Duration of HIV infection [years, mean (sd)] | 7.2 (3.8) | 8.5(3.7) | 0.036 |
cART [years, mean (sd)] | 5.9 (3.6) | 7.9 (3.5) | 0.001 |
Weight [Kg, mean (sd)] | 69.5 (13.5) | 67.8 (9.6) | 0.410 |
Height [m, mean (sd)] | 1.66 (0.09) | 1.64 (0.08) | 0.188 |
BMI [(Kg/m2), mean (sd)] | 25.2 (4.7) | 25.2 (3.8) | 0.976 |
Waist circumference [cm, mean (sd)] | 91.3 (12.7) | 91.6 (9.9) | 0.877 |
Hip circumference [cm, mean (sd)] | 95.7(8.5) | 91.9(6.4) | 0.006 |
Thigh circumference [cm, mean (sd)] | 48,7 (5.1) | 47.1(5.2) | 0.113 |
Arm circumference [cm, mean (sd)] | 26.9 (3.0) | 27.0 (2.7) | 0.939 |
Neck circumference [cm, mean (sd)] | 37.8 (3.6) | 37.6 (3.3) | 0.829 |
Waist/ hip circumference ratio [mean (sd)] | 0.95 (0.09) | 0.99 (0.07) | 0.003 |
CD4 cell count [cells/mm3, mean (sd)] | 522.9 (288.7) | 584.6 (331.9) | 0.289 |
HIV RNA (<50) [n (%)] | 52 (81.3%) | 47 (92.92%) | 0.093 |
HIV risk factor [n (%)] | |||
Injecting drug user | 19 (29.7%) | 11 (21.6%) | 0.073 |
Homosexual contact | 39 (60.9%) | 27 (52.9%) | |
Heterosexual contact | 4 (6.3%) | 11 (21.6%) | |
Others | 1(1.6%) | 2 (3.9%) | |
CDC [n (%)] | |||
A | 32 (50.0%) | 31(60.8%) | 0.248 |
B | – | – | |
C | 32 (50.0) | 20 (39.2) | |
ART [n (%)] | |||
PI | 32 (50.0%) | 30 (58.8%) | 0.346 |
NNRTI | 31 (48.4%) | 23 (45.1%) | 0.721 |
NRTI | 60 (93.8%) | 50 (98.0%) | 0.380 |
Smoking history [n (%)] | |||
Never | 19 (30.2%) | 20 (39.2) | 0.556 |
Current | 33 (52.4%) | 22 (43.1%) | |
Former | 11 (17.5%) | 9 (17.6%) | |
Familial history of CVD [n (%)] | 23 (35.9%) | 21 (41.2%) | 0.566 |
Taking medications [n (%)] | |||
Statins | 14 (22.2%) | 15 (29.4%) | 0.381 |
Fibrates | 29 (46.0%) | 27 (52.9%) | 0.463 |
Oral anti-diabetics | 9 (14.3%) | 12 (23.5%) | 0.306 |
Insulin | 4 (6.3%) | 4 (7.8%) | 0.999 |
Anti-hypertensive drugs | 13 (20.3%) | 12 (24.0%) | 0.637 |
Fat mass [%, mean (sd)] DXA | |||
Total | 22.6 (13.1) | 17.8 (8.0) | 0.017 |
Trunk | 24.1 (13.5) | 22.7 (8.6) | 0.508 |
Leg | 22.3 (15.4) | 9.7 (6.7) | <0.001 |
Arm | 23.4 (16.3) | 18.7 (13.3) | 0.095 |
Fat mass [Kg, mean (sd)] DXA | |||
Total | 16.4 (11.0) | 12.1 (6.6) | 0.012 |
Trunk | 9.1 (6.2) | 8.4 (4.3) | 0.470 |
Leg | 4.7 (3.4) | 1.8 (1.3) | <0.001 |
Arm | 1.9 (1.7) | 13.8 (1.2) | 0.063 |
Body Fat Mass by Quantitative CT | |||
Total fat [cm2, mean (sd)] | 272.6 (188.1) | 259.6 (112.9) | 0.651 |
VAT [cm2, mean (sd)] | 116.8 (95.4) | 154.8 (59.7) | 0.011 |
SAT [cm2, mean (sd)] | 155.8 (123.2) | 104.8 (85.2) | 0.011 |
VAT/SAT ratio [cm2, mean (sd)] | 1.3 (1.8) | 2.4 (1.7) | 0.002 |
Systolic blood pressure [mmHg, mean (sd)] | 122.0 (19.4) | 124.0 (16.0) | 0.558 |
Diastolic blood pressure [mmHg, mean (sd)] | 78.5 (12.1) | 79.2 (11.1) | 0.750 |
Leukocytes [109/L, mean (sd)] | 5.7 (1.7) | 6.5 (1.9) | 0.034 |
Glucose 0 min [mg/dL, mean (sd)] | 106.4 (47.1) | 119.1 (52.1) | 0.175 |
Glucose 2 h [mg/dL, mean (sd)] | 122.3 (46.3) | 138.5 (47.7) | 0.126 |
Insulin 0 min [μU/mL, mean (sd)] | 10.5 (12.8) | 10.9 (6.5) | 0.863 |
Insulin 2 h [μU/mL, mean (sd)] | 53.1 (49.2) | 105.9 (186.8) | 0.072 |
HOMA [mean (sd)] | 2.9 (3.6) | 3.2 (2.6) | 0.601 |
A1c [% mean (sd)] | 5.6 (1.2) | 6.0 (1.1) | 0.123 |
Total cholesterol [mg/dL, mean (sd)] | 213.6 (56.0) | 226.9 (57.6) | 0.216 |
LDL-cholesterol [mg/dL, mean (sd)] | 113.5 (49.2) | 123.7 (49.2) | 0.270 |
HDL-cholesterol [mg/dL, mean (sd)] | 43.9 (12.1) | 43.6 (11.3) | 0.911 |
Non-HDL cholesterol [mg/dL, mean (sd)] | 169.8 (52.0) | 183.2 (52.2) | 0.170 |
Triglycerides[mg/dL, mean (sd)] | 284.4 (191.7) | 298.9 (186.9) | 0.683 |
Apo A1 [mg/dL, mean (sd)] | 110.4 (24.0) | 111.6 (16.6) | 0.763 |
Apo B [mg/dL, mean (sd)] | 104.7 (24.4) | 104.8 (26.7) | 0.975 |
Ratio apo B/apo A1 [mean (sd)] | 0.98 (0.3) | 0.95 (0.3) | 0.604 |
Lp (a) [mg/dL, mean (sd)] | 28.9 (31.0) | 27.5 (33.5) | 0.821 |
Homocysteine [μmol/L, mean (sd)] | 9.4 (4.1) | 9.7 (3.5) | 0.701 |
CRP [mg/L, mean (sd)] | 6.6 (16.6) | 4.3 (4.7) | 0.496 |
hsCRP [mg/dL, mean (sd)] | 0.83 (1.5) | 0.34 (0.31) | 0.496 |
Lactates [mmol/L, mean (sd)] | 1.1 (0.5) | 1.3 (0.6) | 0.056 |
NT-ProBNP [pg/mL, mean (sd)] | 41.2 (74.8) | 31.6 (31.9) | 0.450 |
Fibrinogen [mg/dL, mean (sd)] | 350.8 (103.8) | 342.9 (105.9) | 0.696 |
Microalbumin [mg/L, mean (sd)] | 76.7 (196.6) | 40.6 (91.3) | 0.441 |
Uric acid [mg/L, mean (sd)] | 46.0 (14.6) | 49.8 (12.8) | 0.140 |
Carotid IMT [mm, mean (sd)] | 0.73 (0.196) | 0.82 (0.257) | 0.050 |
Metabolic Syndrome (%) | 31 (49.2%) | 27 (54.0%) | 0.705 |
Carotid IMT measurements
Correlations between cIMT and: | R |
P
|
---|---|---|
Age | 0.709 | <0.001 |
Waist/Hip Ratio | 0.387 | <0.001 |
Neck circumference | 0.202 | 0.007 |
Systolic Blood Pressure | 0.419 | <0.001 |
Glucose 0 min | 0.284 | <0.001 |
Glucose 2 h OGTT | 0.220 | 0.006 |
A1c | 0.285 | <0.001 |
Non-HDL cholesterol | 0.254 | <0.001 |
CRP | 0.196 | 0.005 |
hsCRP | 0.334 | 0.003 |
Homocysteine | 0.150 | 0.032 |
Uric Acid | 0.146 | 0.034 |
Trunk Fat Mass by DXA (g) | 0.168 | 0.0018 |
Total fat on Abdominal CT scan | 0.218 | 0.002 |
VAT on abdominal CT scan | 0.418 | <0.001 |
VAT/SAT on abdominal CT scan | 0.290 | <0.001 |
FMR | 0.250 | <0.001 |
Duration of HIV infection | −0.019 | 0.779 |
Leg Fat Mass by DXA (g) | −0.037 | 0.604 |
Thigh Circumference | −0.095 | 0.169 |
CD4 cell count | −0.027 | 0.701 |
Leukocytes | −0.049 | 0.478 |
SAT on abdominal CT scan | −0.009 | 0.901 |
Insulin 2 h OGTT | −0.089 | 0.271 |
HOMA | 0.094 | 0.185 |
Insulin 0 min | 0.026 | 0.711 |
Lactates | 0.081 | 0.253 |
Triglycerides | 0.109 | 0.113 |
Total Fat Mass by DXA (g) | 0.084 | 0.236 |
Arm Fat Mass by DXA (g) | 0.029 | 0.686 |
cART | 0.024 | 0.727 |
Total Population | With Lipodystrophy | Without Lipodystrophy | |||||||
---|---|---|---|---|---|---|---|---|---|
Baseline | 1 year after |
p
| Baseline | 1 year after |
P
| Baseline | 1 year after |
p
| |
Weight [Kg, mean (sd)] | 68.7 (11.9) | 67.8 (11.8) | 0.474 | 67.8 (9.6) | 65.7 (12.0) | 0.360 | 69.5 (13.5) | 69.5 (13.5) | 0.977 |
Height [m, mean (sd)] | 1.65 (0.1) | 1.65 (0.1) | – | 1.64 (0.08) | 1.64 (0.08) | – | 1.66 (0.09) | 1.66 (0.09) | – |
BMI [(Kg/m2), mean (sd)] | 25.2 (4.3) | 25.0 (4.9) | 0.547 | 25.2 (3.8) | 24.5 (4.7) | 0.359 | 25.2 (4.7) | 25.4 (5.1) | 0.849 |
Waist circumference [cm, mean (sd)] | 91.4 (11.5) | 90.9 (10.8) | 0.654 | 91.6 (9.9) | 89.7 (11.2) | 0.402 | 91.4 (12.8) | 92.0 (10.4) | 0.804 |
Hip circumference [cm, mean (sd)] | 94.0 (7.8) | 93.2 (6.8) | 0.496 | 91.9(6.4) | 92.6 (7.0) | 0.561 | 95.7(8.6) | 93.6 (6.7) | 0.120 |
Thigh circumference [cm, mean (sd)] | 48.0 (5.2) | 45.3 (4.2) | <0.001 | 47.2 (5.2) | 45.0 (4.14) | 0.023 | 48,7 (5.1) | 45.5 (4.4) | <0.001 |
Arm circumference [cm, mean (sd)] | 27.0 (2.9) | 26.1 (2.8) | 0.049 | 27.0 (2.7) | 25.9 (2.9) | 0.082 | 27.0 (3.1) | 26.5 (2.8) | 0.353 |
Neck circumference [cm, mean (sd)] | 37.7 (3.5) | 36.9 (3.5) | 0.143 | 37.6 (3.3) | 36.8 (3.9) | 0.327 | 37.8 (3.6) | 37.1 (3.2) | 0.322 |
Waist/ hip circumference ratio [mean (sd)] | 0.97 (0.08) | 0.97 (0.08) | 0.786 | 1.00 (0.07) | 0.97 (0.09) | 0.086 | 0.95 (0.09) | 0.98 (0.08) | 0.066 |
Fat mass [%, mean (sd)] DXA | |||||||||
Total | 20.5 (11.4) | 21.6 (10.4) | 0.554 | 17.8 (8.0) | 19.9 (10.5) | 0.264 | 22.6 (13.1) | 22.9 (10.1) | 0.941 0.418 |
Trunk | 23.5 (11.6) | 24.8 (10.8) | 0.561 | 22.7 (8.6) | 22.7 (11.2) | 0.980 | 24.1 (13.5) | 26.5 (10.2) | |
Leg | 16.7 (13.8) | 16.2 (11.0) | 0.898 | 9.7 (6.7) | 15.0 (10.4) | 0.007 | 22.3 (15.4) | 17.2 (11.5) | 0.088 |
Arm | 21.3 (15.2) | 23.8 (15.0) | 0.267 | 18.7(13.3) | 22.4 (15.8) | 0.232 | 23.4 (16.3) | 24.9 (14.4) | 0.631 |
Fat mass [Kg, mean (sd)] DXA | |||||||||
Total | 14.5 (9.5) | 14.7 (8.3) | 0.867 | 12.1 (6.7) | 13.1 (7.7) | 0.406 | 16.4 (11.0) | 16.0 (8.6) | 0.736 |
Trunk | 8.7 (5.4) | 9.0 (5.0) | 0.897 | 8.4 (4.3) | 8.0 (4.9) | 0.766 | 9.1 (6.2) | 9.8 (5.1) | 0.641 |
Leg | 3.5 (3.0) | 3.3 (2.5) | 0.810 | 1.8 (1.3) | 2.8 (2.0) | 0.008 | 4.7 (3.4) | 3.6 (2.8) | 0.047 |
Arm | 1.7 (1.5) | 1.8 (1.3) | 0.293 | 1.4 (1.2) | 1.7 (1.3) | 0.238 | 1.9 (1.7) | 1.9 (1.3) | 0.744 |
Body Fat Mass by Quantitative CT | |||||||||
Total fat [cm2, mean (sd)] | 266.8 (158.4) | 274.5 (146.0) | 0.625 | 259.6 (112.9) | 249.6 (160.5) | 0.708 | 272.6 (188.1) | 295.3 (130.4) | 0.361 |
VAT [cm2, mean (sd)] | 133.8 (83.2) | 136.0 (85.1) | 0.670 | 154.8 (59.7) | 126.2 (97.2) | 0.049 | 116.8 (95.4) | 144.2 (73.3) | 0.024 |
SAT [cm2, mean (sd)] | 133.0 (110.4) | 139.3 (95.7) | 0.314 | 104.9 (85.2) | 125.2 (95.8) | 0.180 | 155.8 (123.2) | 151.1 (94.8) | 0.848 |
VAT/SAT ratio [cm2, mean (sd)] | 1.8 (1.8) | 1.6 (1.8) | 0.298 | 2.4 (1.7) | 1.6 (1.6) | 0.019 | 1.3 (1.8) | 1.6 (1.9) | 0.185 |
Systolic blood pressure [mmHg, mean (sd)] | 122.9 (18.0) | 117.2 (18.1) | 0.005 | 124.0 (16.1) | 119.3 (20.9) | 0.072 | 122.0 (19.4) | 115.6 (15.5) | 0.027 |
Diastolic blood pressure [mmHg, mean (sd)] | 78.8 (11.6) | 71.8 (8.9) | <0.001 | 79.2 (11.1) | 72.2 (8.6) | 0.001 | 78.5 (12.1) | 71.6 (9.2) | <0.001 |
Glucose 0 min [mg/dL, mean (sd)] | 112.0 (49.6) | 101.2 (25.6) | 0.481 | 119.1 (52.1) | 104.6 (28.7) | 0.307 | 106.4 (47.1) | 99.4 (22.8) | 0.992 |
Glucose 2 h [mg/dL, mean (sd)] | 129.5 (47.4) | 137.3 (47.6) | 0.445 | 138.5 (47.7) | 137.7 (47.5) | 0.819 | 122.3 (46.3) | 136.9 (48.2) | 0.451 |
Insulin 0 min [μU/mL, mean (sd)] | 10.7 (10.4) | 13.3 (14.8) | 0.166 | 10.9 (6.5) | 12.1 (9.9) | 0.419 | 10.5 (12.8) | 14.1 (17.7) | 0.227 |
Insulin 2 h [μU/mL, mean (sd)] | 76.5 (131.5) | 71.8 (60) | 0.886 | 105.9 (186.8) | 69.9 (60.4) | 0.220 | 53.1 (49.2) | 73.3 (59.9) | 0.307 |
HOMA [mean (sd)] | 3.1 (3.2) | 3.5 (4.8) | 0.552 | 3.2 (2.5) | 3.2 (2.9) | 0.857 | 2.9 (3.6) | 3.8 (5.8) | 0.369 |
A1c [% mean (sd)] | 5.8 (1.2) | 5.5 (0.8) | 0.095 | 5.9 (1.1) | 5.5 (0.9) | 0.096 | 5.6 (1.2) | 5.4 (0.7) | 0.556 |
Total cholesterol [mg/dL, mean (sd)] | 219.5 (56.8) | 204.7 (41.4) | 0.012 | 226 (57.6) | 203.8 (41.9) | 0.007 | 213.6 (56.0) | 205.4 (41.2) | 0.396 |
LDL-cholesterol [mg/dL, mean (sd)] | 118.0 (49.2) | 135.7 (31.3) | 0.001 | 123.7 (49.2) | 133.9 (28.4) | 0.153 | 113.5 (49.2) | 137.2 (33.6) | 0.001 |
HDL-cholesterol [mg/dL, mean (sd)] | 43.8 (11.7) | 48.6 (13.3) | 0.012 | 43.6 (11.3) | 50.6 (14.6) | 0.018 | 43.9 (12.1) | 46.9 (12.0) | 0.280 |
Non-HDL cholesterol [mg/dL, mean (sd)] | 175.7 (52.3) | 156.2 (37.6) | <0.001 | 183.2 (52.2) | 153.2 (37.6) | <0.001 | 169.8 (52.0) | 158.5 (37.6) | 0.192 |
Triglycerides [mg/dL, mean (sd)] | 290.8 (189.0) | 180.5 (110.5) | <0.001 | 298.9 (186.9) | 165.6 (107.2) | <0.001 | 284.4 (191.7) | 192.3 (112.5) | 0.001 |
Apo A1 [mg/dL, mean (sd)] | 111 (21) | 126.4 (24.0) | <0.001 | 111.6 (16.6) | 130.0 (25.2) | 0.001 | 110.4 (23.9 | 123.7 (22.8) | 0.002 |
Apo B [mg/dL, mean (sd)] | 104.7 (25.3) | 101.4 (21.7) | <0.001 | 104.8 (26.7) | 100.0 (21.6) | 0.126 | 104.7 (24.4) | 102.4 (22.0) | 0.706 |
Ratio apo B/apo A1 [mean (sd)] | 0.97 (0.3) | 0.83 (0.3) | <0.001 | 0.95 (0.3) | 0.79 (0.2) | 0.001 | 0.98 (0.3) | 0.87 (0.3) | 0.02 |
Lp (a) [mg/dL, mean (sd)] | 28.3 (32.0) | 36.3 (43.3) | 0.289 | 27.5 (33.5 | 44.4 (47.8) | 0.102 | 28.9 (30.9) | 30.1 (38.7) | 0.906 |
Homocysteine [μmol/L, mean (sd)] | 9.5 (3.8) | 11.1 (4.8) | 0.005 | 9.7 (3.5) | 12.1 (5.2) | 0.008 | 9.4 (4.1) | 10.3 (4.3) | 0.179 |
CRP [mg/L, mean (sd)] | 5.6 (12.8) | 5.1 (11.3) | 0.147 | 4.3 (4.7) | 6.1 (14.4) | 0.857 | 6.6 (16.6) | 4.3 (8.0) | 0.038 |
hsCRP [mg/dL, mean (sd)] | 0.6 (1.2) | 0.5 (1.2) | 0.030 | 0.34 (0.31) | 0.65 (1.6) | 0.225 | 0.83 (1.5) | 0.43 (0.8) | 0.066 |
Lactates [mmol/L, mean (sd)] | 1.2 (0.5) | 1.4 (0.6) | 0.002 | 1.3 (0.6) | 1.4 (0.6) | 0.307 | 1.1 (0.48) | 1.4 (0.5) | 0.001 |
NT-ProBNP [pg/mL, mean (sd)] | 36.8 (59.0) | 39.0 (63.0) | 0.241 | 31.6 (31.9) | 35.9 (33.2) | 0.177 | 41.2 (74.8) | 41.3 (79.0) | 0.769 |
Fibrinogen [mg/dL, mean (sd)] | 347.3 (104.4) | 332.6 (79,0) | 0.611 | 342.9 (105.9) | 333.8 (80.1) | 0.841 | 350.8 (103.8) | 331.6 (78.8) | 0.370 |
Microalbumin [mg/L, mean (sd)] | 58.2 (151.4) | 36.0 (159.8) | 0.527 | 40.6 (91.3) | 20.5 (35.6) | 0.551 | 76.7 (196.6) | 47.7 (209.3) | 0.852 |
Uric acid [mg/L, mean (sd)] | 47.7 (14.0) | 44.1 (14.6) | 0.022 | 49.8 (12.8) | 43.7 (13.0) | 0.005 | 45.9 (14.6) | 474.3 (15.8) | 0.470 |
Carotid IMT [mm, mean (sd)] | 0.77 (0.23) | 0.87 (0.32) | 0.001 | 0.82 (0.26) | 0.92 (0.33) | 0.037 | 0.73 (0.20) | 0.84 (0.30) | 0.012 |
Metabolic Syndrome (%) | 58 (51.3) | 48 (43.2) | 0.203 | 27 (54.0) | 19 (38.8) | 0.134 | 31 (49.2) | 29 (46.8) | 0.851 |
One year follow-up
Total population
Patients with Lipodystrophy
Patients without Lipodystrophy
Carotid IMT measurements
Baseline | One Year follow-up |
P
| |
---|---|---|---|
Waist/Hip Ratio [mean (sd)] | 0.97 (0.08) | 0.97 (0.08) | 0.786 |
Neck circumference [cm, mean (sd)] | 37.7 (3.5) | 36.9 (3.5) | 0.143 |
Systolic Blood Pressure [mmHg, mean (sd)] | 122.9 (18.0) | 117.2 (18.1) | 0.005 |
Glucose 0 min [mg/dL, mean (sd)] | 112.0 (49.6) | 101.7 (25.6) | 0.481 |
Glucose 2 h OGTT [mg/dL, mean (sd)] | 129.5 (47.4) | 137.3 (47.6) | 0.445 |
A1c [% mean (sd)] | 5.8 (1.2) | 5.5 (0.8) | 0.095 |
Non-HDL cholesterol [mg/dL, mean (sd)] | 175.7 (52.3) | 156.2 (37.6) | <0.001 |
CRP [mg/L, mean (sd)] | 5.6 (12.8) | 5.1 (11.3) | 0.147 |
hsCRP [mg/dL, mean (sd)] | 0.6 (1.2) | 0.5 (1.2) | 0.030 |
Homocysteine [μmol/L, mean (sd)] | 9.5 (3.8) | 11.1 (4.8) | 0.005 |
Uric Acid [mg/L, mean (sd)] | 47.7 (14.0) | 44.1 (14.6) | 0.022 |
Trunk Fat Mass by DXA (kg) [Kg, mean (sd)] | 8.7 (5.4) | 9.0 (5.0) | 0.897 |
Total fat on Abdominal CT scan [cm2, mean (sd)] | 266.8 (158.4) | 274.5 (146.0) | 0.625 |
VAT on abdominal CT scan [cm2, mean (sd)] | 133.8 (83.2) | 136.0 (85.1) | 0.670 |
VAT/SAT on abdominal CT scan [cm2, mean (sd)] | 1.8 (1.8) | 1.6 (1.8) | 0.298 |
Total Sample | cIMT baseline | cIMT 1 year follow up |
P
|
---|---|---|---|
Crude model | 0.770 (0.728–0.812) | 0.874 (0.815–0.932) | <0.001 |
Model adjusted for age | 0.770 (0.738–0.802) | 0.874 (0.816–0.932) | <0.001 |
Model adjusted for age and glucose | 0.770 (0.737–0.803) | 0.874 (0.816–0.932) | <0.001 |
Model adjusted for age, glucose and Triglycerides | 0.770 (0.737–0.803) | 0.874 (0.815–0.933) | 0.001 |
Model adjusted for age, glucose, triglycerides and Systolic Pressure | 0.770 (0.738–0.802) | 0.874 (0.815–0.932) | 0.050 |
Model adjusted for age, glucose, triglycerides, Systolic Pressure and WHR | 0.770 (0.737–0.803) | 0.874 (0.815–0.933) | 0.514 |
Patients with Lipodystrophy | |||
Crude model | 0.817 (0.744–0.889) | 0.919 (0.825–1.01) | 0.030 |
Model adjusted for age | 0.817 (0.757–0.876) | 0.919 (0.826–1.01) | 0.027 |
Model adjusted for age and glucose | 0.817 (0.756–0.877) | 0.919 (0.825–1.01) | 0.018 |
Model adjusted for age, glucose and triglycerides | 0.817 (0.756–0.877) | 0.919 (0.825–1.01) | 0.053 |
Model adjusted for age, glucose, triglycerides and Systolic Pressure | 0.817 (0.756–0.878) | 0.919 (0.825–1.01) | 0.401 |
Model adjusted for age, glucose, triglycerides, Systolic Pressure and WHR | 0.817 (0.755–0.878) | 0.919 (0.823–1.01) | 0.644 |
Patients Without Lipodystrophy | |||
Crude model | 0.733 (0.684–0.784) | 0.838 (0.763–0.914) | 0.020 |
Model adjusted for age | 0.733 (0.698–0.767) | 0.838 (0.763–0.914) | 0.003 |
Model adjusted for age and glucose | 0.733 (0.698–0.768) | 0.838 (0.763–0.914) | 0.015 |
Model adjusted for age, glucose and triglycerides | 0.733 (0.698–0.768) | 0.838 (0.762–0.915) | 0.017 |
Model adjusted for age, glucose, triglycerides and Systolic Pressure | 0.733 (0.698–0.768) | 0.838 (0.762–0.915) | 0.130 |
Model adjusted for age, glucose, triglycerides, Systolic Pressure and WHR | 0.733 (0.698–0.768) | 0.838 (0.761–0.915) | 0.676 |