nach oben

Infection

Erschienen in:

01.04.2013 | Case Report

Visceral leishmaniasis revealed by a squamous cell carcinoma in an HIV-1 infected patient

verfasst von: P. Donati, G. Paolino, C. Panetta, L. Muscardin, C. Cota, M. Giuliani

Erschienen in: Infection | Ausgabe 2/2013

Einloggen, um Zugang zu erhalten

Abstract

We present a case of visceral leishmaniasis confirmed after the histological investigation of an ulcerate lesion of the scalp in an HIV-1-infected patient receiving highly active antiretroviral therapy (HAART). Histological examination of the skin lesion revealed a squamous cell carcinoma superinfected by amastigotes of Leishmania infantum from the bloodstream. Because HIV-1-infected individuals can harbour parasitic infections in normal and neoplastic tissue, it is necessary to examine carefully any skin lesions, particularly those with uncommon aspects or a worsening course, to exclude superinfections by unsuspected pathogens.

Desjeux P, Alvar J. Leishmania/HIV co-infections: epidemiology in Europe. Ann Trop Med Parasitol. 2003;97:3–15.PubMedCrossRef

Paredes R, Munoz J, Diaz I, et al. Leishmaniasis in HIV infection. J Postgrad Med. 2003;49:39–49.PubMedCrossRef

Gradoni L, Scalone A, Gramiccia M, Troiani M. Epidemiological surveillance of leishmaniasis in HIV-1-infected individuals in Italy. AIDS. 1996;10:785–91.PubMedCrossRef

Alvar J, Aparicio P, Aseffa A, Den Boer M, Canavate C, et al. The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev. 2008;21:334–59.PubMedCrossRef

Garg R, Barat C, Ouellet M, Lodge R, Tremblay MJ. Leishmania infantum amastigotes enhance HIV-1 production in cocultures of human dendritic cells and CD4+ T cells by inducing secretion of IL-6 and TNF-α. PLOS Negl Trop Dis. 2009;3:e441.PubMedCrossRef

Jimenez-Exposito MJ, Alonso-Villaverde C, Sarda P, Masana L. Visceral leishmaniasis in HIV-infected patients with non-detectable HIV-1 viral load after highly active antiretroviral therapy. AIDS. 1999;13:152–3.PubMed

Gallego MA, Aguillar A, Plaza S, et al. Kaposis’s sarcoma with an intense parasitization by Leishmania. Cutis. 1996;57:103–5.PubMed

Castellano VM, Rodriguez-Peraltro JL, Alonso S, Gomez-De la Fuente E, Ibarrola C. Dermatofibroma parasitized by Leishmania in HIV infection: a new morphologic expression of the dermal Kala Azar in an immunodepressed patient. J Cutan Pathol. 1999;26:516–9.PubMedCrossRef

Bosch RJ, Rodrigo AB, Sanchez P, de Galvez MV, Herrera E. Presence of Leishmania organisms in specific and non-specific skin lesions in HIV-infected individuals with visceral leishmaniasis. Int J Dermatol. 2002;41:670–5.PubMedCrossRef

10.

Perrin C, Michielis JF, Bernard E, et al. Cutaneous spindle-cell pseudotumors due to mycobacterium gordonae and Leishmania Infantum: an immunophenotypic study. Am J Dermatopathol. 1993;15:553–8.PubMedCrossRef

11.

Antinori S, Calattini S, Longhi E, et al. Clinical use of polymerase chain reaction performed on peripheral blood and bone marrow samples for the diagnosis and monitoring of visceral leishmaniasis in HIV-infected and HIV-uninfected patients: a single-center, 8-year experience in Italy and review of the literature. Clin Infect Dis. 2007;44:1602–10.PubMedCrossRef

12.

Bourgeois N, Bastien P, Reynes J, Makinson A, Rouanet I, Lachaud L. ‘Active chronic visceral leishmaniasis’ in HIV-1-infected patients demonstrated by biological and clinical long-term follow-up of 10 patients. HIV Med. 2010;11:670–3.PubMedCrossRef

13.

de Oliveira CP, Junger J, do Espirito Santo Silva Pires F, Mattos M, Oliveira-Neto MP, Fernandes O, Pirmez C. Haematogenous dissemination of Leishmania (Viannia) braziliensis in human American tegumentary leishmaniasis. Trans R Soc Trop Med Hyg. 2006;100:1112–7.CrossRef

14.

del Giudice P, Marty P, Lacour JP, Perrin C, Pratlong F, Haas H, Dellamonica P, Le Fichoux Y. Cutaneous leishmaniasis due to Leishmania infantum. Case reports and literature review. Arch Dermatol. 1998;134(2):193–8.PubMedCrossRef

15.

Boutros N, Hawkins D, Nelson M, et al. Burkitt lymphoma and leishmaniasis in the same tissue sample in an AIDS patient. Histopathology. 2006;48:880–1.PubMedCrossRef

16.

Kopterides P, Mourtzoukou EG, Skopelitis E, et al. Aspects of the association between leishmaniasis and malignant disorders. Trans R Soc Trop Med Hyg. 2007;101:1181–9.PubMedCrossRef

17.

Friedman R, Hanson S, Goldberg LH, et al. Squamous cell carcinoma arising in a Leishmania scar. Dermatol Surg. 2003;29:1148–9.PubMedCrossRef

18.

Bielory BP, Lari HB, Mirani N, Kapila R, Fizhugh VA, Turbin RE. Conjunctival squamous cell carcinoma harbouring Leishmania amastigotes in a human immunodeficiency virus positive patient. Arch Ophtalmol. 2011;129:1230–1.CrossRef

19.

Armengot-Carbò M, Carmen-Ramon R, Nicolas-Rodrigo B, Marco-Ferrando J. Unsuspected visceral leishmaniasis infiltrating a squamous cell carcinoma. Actas Dermosifiliogr. 2012;103:321–323.

Titel: Visceral leishmaniasis revealed by a squamous cell carcinoma in an HIV-1 infected patient
verfasst von: P. Donati
G. Paolino
C. Panetta
L. Muscardin
C. Cota
M. Giuliani
Publikationsdatum: 01.04.2013
Verlag: Springer-Verlag
Erschienen in: Infection / Ausgabe 2/2013
Print ISSN: 0300-8126
Elektronische ISSN: 1439-0973
DOI: https://doi.org/10.1007/s15010-013-0412-4

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

15.04.2024 | Inkretinmimetika | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Visceral leishmaniasis revealed by a squamous cell carcinoma in an HIV-1 infected patient

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Fast jeder zehnte Magen bei Endoskopie noch nicht entleert

Verbesserung der HDL-Funktion als Lipidtherapie floppt in Mega-Studie

Blutdrucksenkung per Spritze additiv zur Standardtherapie wirksam

Vitiligo: Prävalenz steigt und viele Erkrankte werden spät behandelt

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2013

Adherence and factors associated with influenza vaccination among subjects with asthma in Spain

Clinical and pathological characteristics of mycobacterial tenosynovitis and arthritis

Conversion rates of an interferon-γ release assay and the tuberculin skin test in the serial monitoring of healthcare workers

Meningitis caused by Abiotrophia defectiva: case report and literature review

Sources of systematic errors in the epidemiology of vancomycin-resistant enterococci

Organic cation transporters OCT1 and OCT2 determine the accumulation of lamivudine in CD4 cells of HIV-infected patients

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Fast jeder zehnte Magen bei Endoskopie noch nicht entleert

Verbesserung der HDL-Funktion als Lipidtherapie floppt in Mega-Studie

Blutdrucksenkung per Spritze additiv zur Standardtherapie wirksam

Vitiligo: Prävalenz steigt und viele Erkrankte werden spät behandelt

Update Innere Medizin