Skip to main content
Erschienen in: European Journal of Orthopaedic Surgery & Traumatology 2/2013

01.02.2013 | General Review

Viscosupplementation with hyaluronic acid in the treatment for cartilage lesions: a review of current evidence and future directions

verfasst von: Travis E. Clegg, David Caborn, Cyril Mauffrey

Erschienen in: European Journal of Orthopaedic Surgery & Traumatology | Ausgabe 2/2013

Einloggen, um Zugang zu erhalten

Abstract

Diseases involving the articular cartilage are one of the leading causes of physical impairment among the adult population. While surgical technique and advancement have allowed us effective means at treating these diseases, this is not without significant risk and morbidity. With a very solid safety profile, viscosupplementation with hyaluronic acid (HA) derivatives has become an excellent modality for treating diseased articular cartilage. Recent literature supports the use of HA not only in the management of the pain associated with osteoarthritis but also as a disease-modifying agent as well. Further studies have started to define exciting new roles for viscosupplementation in the treatment for acute injuries to the joint microenvironment.
Literatur
1.
Zurück zum Zitat Ayral X (2001) Injections in the treatment of osteoarthritis. Best Prac Res Clin Rheumatol 15:609–626CrossRef Ayral X (2001) Injections in the treatment of osteoarthritis. Best Prac Res Clin Rheumatol 15:609–626CrossRef
2.
Zurück zum Zitat Tehranzadeh J, Booya F, Root J (2005) Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Acta Radiol 3:288–296CrossRef Tehranzadeh J, Booya F, Root J (2005) Cartilage metabolism in osteoarthritis and the influence of viscosupplementation and steroid: a review. Acta Radiol 3:288–296CrossRef
3.
Zurück zum Zitat Lo G, Michael L, McAlindon T (2003) Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. JAMA 290(23):3115–3121PubMedCrossRef Lo G, Michael L, McAlindon T (2003) Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. JAMA 290(23):3115–3121PubMedCrossRef
4.
Zurück zum Zitat Watterson JR, Esdaile JM (2000) Viscosupplementation: therapeutic mechanisms and clinical potential in osteoarthritis of the knee. J Am Acad Orthop Surg. 8(5):277–284PubMed Watterson JR, Esdaile JM (2000) Viscosupplementation: therapeutic mechanisms and clinical potential in osteoarthritis of the knee. J Am Acad Orthop Surg. 8(5):277–284PubMed
5.
Zurück zum Zitat Moreland LW (2003) Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther 5(2):54–67PubMedCrossRef Moreland LW (2003) Intra-articular hyaluronan (hyaluronic acid) and hylans for the treatment of osteoarthritis: mechanisms of action. Arthritis Res Ther 5(2):54–67PubMedCrossRef
6.
Zurück zum Zitat Buckwalter JA, Saltzman C, Brown T (2004) The impact of osteoarthritis: implications for research. Clin Orthop Relat Res 427(suppl):S6–S15PubMedCrossRef Buckwalter JA, Saltzman C, Brown T (2004) The impact of osteoarthritis: implications for research. Clin Orthop Relat Res 427(suppl):S6–S15PubMedCrossRef
7.
Zurück zum Zitat (2007) Physicians desk reference, 61st edn. Thomson PDR, Montvale (2007) Physicians desk reference, 61st edn. Thomson PDR, Montvale
8.
Zurück zum Zitat Goldberg VM, Buckwalter JA (2005) Hyaluronans in the treatment of osteoarthritis of the knee: evidence for disease-modifying activity. Osteoarth Cartil 13(3):216–224CrossRef Goldberg VM, Buckwalter JA (2005) Hyaluronans in the treatment of osteoarthritis of the knee: evidence for disease-modifying activity. Osteoarth Cartil 13(3):216–224CrossRef
9.
Zurück zum Zitat Chevalier X, Jerosch J, Goupille P, van Dijk N, Luyten FP, Scott DL, Bailleul F, Pavelka K (2010) Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial. Ann Rheum Dis 69(1):113–119PubMedCrossRef Chevalier X, Jerosch J, Goupille P, van Dijk N, Luyten FP, Scott DL, Bailleul F, Pavelka K (2010) Single, intra-articular treatment with 6 ml hylan G-F 20 in patients with symptomatic primary osteoarthritis of the knee: a randomised, multicentre, double-blind, placebo controlled trial. Ann Rheum Dis 69(1):113–119PubMedCrossRef
10.
Zurück zum Zitat Conrozier T, Jerosch J, Beks P, Kemper F, Euller-Ziegler L, Bailleul F, Chevalier X (2009) Prospective, multi-centre, randomised evaluation of the safety and efficacy of five dosing regimens of viscosupplementation with hylan G-F 20 in patients with symptomatic tibio-femoral osteoarthritis: a pilot study. Arch Orthop Trauma Surg 129(3):417–423PubMedCrossRef Conrozier T, Jerosch J, Beks P, Kemper F, Euller-Ziegler L, Bailleul F, Chevalier X (2009) Prospective, multi-centre, randomised evaluation of the safety and efficacy of five dosing regimens of viscosupplementation with hylan G-F 20 in patients with symptomatic tibio-femoral osteoarthritis: a pilot study. Arch Orthop Trauma Surg 129(3):417–423PubMedCrossRef
11.
Zurück zum Zitat Puhl W, Bernau A, Greiling H et al (1993) Intra-articular sodium hyaluronate in osteoarthritis of the knee: a multicenter, double-blind study. Osteoarthr Cartil 1(4):233–241PubMedCrossRef Puhl W, Bernau A, Greiling H et al (1993) Intra-articular sodium hyaluronate in osteoarthritis of the knee: a multicenter, double-blind study. Osteoarthr Cartil 1(4):233–241PubMedCrossRef
12.
Zurück zum Zitat Bellamy N, Campbell J, Robinson V et al. (2006) Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev CD005321 Bellamy N, Campbell J, Robinson V et al. (2006) Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev CD005321
13.
Zurück zum Zitat Richmond J, Hunter D, Irrgang J et al (2009) American Academy of Orthopaedic Surgeons. Treatment of osteoarthritis of the knee (nonarthroplasty). J Am Acad Orthop Surg 17(9):591–600PubMed Richmond J, Hunter D, Irrgang J et al (2009) American Academy of Orthopaedic Surgeons. Treatment of osteoarthritis of the knee (nonarthroplasty). J Am Acad Orthop Surg 17(9):591–600PubMed
14.
Zurück zum Zitat Wang CT, Lin J, Chang CJ, Lin YT, Hou SM (2004) Therapeutic effects of hyaluroinc acid on osteoarthritis of the knee: a meta-analysis of randomized controlled trials. J Bone Joint Surg Am 86-A:538–545PubMed Wang CT, Lin J, Chang CJ, Lin YT, Hou SM (2004) Therapeutic effects of hyaluroinc acid on osteoarthritis of the knee: a meta-analysis of randomized controlled trials. J Bone Joint Surg Am 86-A:538–545PubMed
15.
Zurück zum Zitat Altman RD, Moskowitz R (1999) Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group. J Rheumatol 26(5):1216 Altman RD, Moskowitz R (1999) Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group. J Rheumatol 26(5):1216
16.
Zurück zum Zitat Sen C, Gunes T, Saygi B et al (2008) The chondroprotective effect of intra-articular hyaluronic acid at early stages of osteoarthritis: an experimental study in rabbits. Acta Orthop Traumatol Turc 38(5):348–352 Sen C, Gunes T, Saygi B et al (2008) The chondroprotective effect of intra-articular hyaluronic acid at early stages of osteoarthritis: an experimental study in rabbits. Acta Orthop Traumatol Turc 38(5):348–352
17.
Zurück zum Zitat Conrozier T, Bertin P, Mathieu P, Charlot J, Bailleul F, Treves R, Vignon E, Chevalier X (2003) Intra-articular injections of hylan G-F 20 in patients with symptomatic hip osteoarthritis: an open-label, multicentre, pilot study. Clin Exp Rheumatol 21(5):605–610PubMed Conrozier T, Bertin P, Mathieu P, Charlot J, Bailleul F, Treves R, Vignon E, Chevalier X (2003) Intra-articular injections of hylan G-F 20 in patients with symptomatic hip osteoarthritis: an open-label, multicentre, pilot study. Clin Exp Rheumatol 21(5):605–610PubMed
18.
Zurück zum Zitat Sun SF, Chou YJ, Hsu CW, Chen WL (2009) Hyaluronic acid as a treatment for ankle osteoarthritis. Curr Rev Musculoskelet Med 2(2):78–82PubMedCrossRef Sun SF, Chou YJ, Hsu CW, Chen WL (2009) Hyaluronic acid as a treatment for ankle osteoarthritis. Curr Rev Musculoskelet Med 2(2):78–82PubMedCrossRef
19.
Zurück zum Zitat Blaine T, Moskowitz R, Udell J, Skyhar M, Levin R, Friedlander J, Daley M, Altman R (2008) Treatment of persistent shoulder pain with sodium hyaluronate: a randomized, controlled trial. A multicenter study. J Bone Joint Surg Am 90(5):970–979PubMedCrossRef Blaine T, Moskowitz R, Udell J, Skyhar M, Levin R, Friedlander J, Daley M, Altman R (2008) Treatment of persistent shoulder pain with sodium hyaluronate: a randomized, controlled trial. A multicenter study. J Bone Joint Surg Am 90(5):970–979PubMedCrossRef
20.
Zurück zum Zitat Kaplan LD, Lu Y, Snitzer J, Nemke B, Hao Z, Biro S, Albiero W, Stampfli HF, Markel M, Popkin C, Baum SZ (2009) The effect of early hyaluronic acid delivery on the development of an acute articular cartilage lesion in a sheep model. Am J Sports Med 37(12):2323–2327PubMedCrossRef Kaplan LD, Lu Y, Snitzer J, Nemke B, Hao Z, Biro S, Albiero W, Stampfli HF, Markel M, Popkin C, Baum SZ (2009) The effect of early hyaluronic acid delivery on the development of an acute articular cartilage lesion in a sheep model. Am J Sports Med 37(12):2323–2327PubMedCrossRef
21.
Zurück zum Zitat Sonoda M, Harwood FL, Amiel ME, Moriya H, Temple M, Chang DG, Lottman LM, Sah RL, Amiel D (2000) The effects of hyaluronan on tissue healing after meniscus injury and repair in a rabbit model. Am J Sports Med 28(1):90–97PubMed Sonoda M, Harwood FL, Amiel ME, Moriya H, Temple M, Chang DG, Lottman LM, Sah RL, Amiel D (2000) The effects of hyaluronan on tissue healing after meniscus injury and repair in a rabbit model. Am J Sports Med 28(1):90–97PubMed
22.
Zurück zum Zitat Hempfling H (2007) Intra-articular hyaluronic acid after knee arthroscopy: a two-year study. Knee Surg Sports Traumatol Arthrosc 15(5):537–546PubMedCrossRef Hempfling H (2007) Intra-articular hyaluronic acid after knee arthroscopy: a two-year study. Knee Surg Sports Traumatol Arthrosc 15(5):537–546PubMedCrossRef
23.
Zurück zum Zitat Huang MH, Yang RC, Chou PH (2007) Preliminary effects of hyaluronic acid on early rehabilitation of patients with isolated anterior cruciate ligament reconstruction. Clin J Sport Med 17(4):242–250PubMedCrossRef Huang MH, Yang RC, Chou PH (2007) Preliminary effects of hyaluronic acid on early rehabilitation of patients with isolated anterior cruciate ligament reconstruction. Clin J Sport Med 17(4):242–250PubMedCrossRef
24.
Zurück zum Zitat Yagishita K, Sekiya I, Sakaguchi Y et al (2005) The effect of hyaluronan on tendon healing in rabbits. Arthroscopy 21(11):1330–1336PubMedCrossRef Yagishita K, Sekiya I, Sakaguchi Y et al (2005) The effect of hyaluronan on tendon healing in rabbits. Arthroscopy 21(11):1330–1336PubMedCrossRef
25.
Zurück zum Zitat Shikhman AR, Kuhn K, Alaaeddine N, Lutz M (2001) N-acetylglucosamine prevents IL1 mediated activation of human chondrocytes. J Immunol 166:5155–5160PubMed Shikhman AR, Kuhn K, Alaaeddine N, Lutz M (2001) N-acetylglucosamine prevents IL1 mediated activation of human chondrocytes. J Immunol 166:5155–5160PubMed
26.
Zurück zum Zitat Shikhman AR, Amiel D, Lima DD, Hwung SB, Hu C, Xu A, Hashimoto S, Kobayashi K, Sasho T, Lotz MK (2005) Chondroprotective activity of N-Acetylglucosamine in rabbits with experimental osteoarthritis. Ann Rheum Dis 64:89–94PubMedCrossRef Shikhman AR, Amiel D, Lima DD, Hwung SB, Hu C, Xu A, Hashimoto S, Kobayashi K, Sasho T, Lotz MK (2005) Chondroprotective activity of N-Acetylglucosamine in rabbits with experimental osteoarthritis. Ann Rheum Dis 64:89–94PubMedCrossRef
27.
Zurück zum Zitat Campo GM, Avenoso A, Campo S, Ferlazzo AM, Altavilla D, Calatroni A (2003) Efficacy of treatment with glucosaminoglycans on experimental collagen induced arthritis in rats. Arthritis Res Ther 5:R122–R131PubMedCrossRef Campo GM, Avenoso A, Campo S, Ferlazzo AM, Altavilla D, Calatroni A (2003) Efficacy of treatment with glucosaminoglycans on experimental collagen induced arthritis in rats. Arthritis Res Ther 5:R122–R131PubMedCrossRef
28.
Zurück zum Zitat Sabaratnam S, Coleman PJ, Badrick E, Mason RM, Levick JR (2002) Interactive effect of chondroitin sulphate C and hyaluronan on fluid movement across rabbit synovium. J Physiol 540(1):271–284PubMedCrossRef Sabaratnam S, Coleman PJ, Badrick E, Mason RM, Levick JR (2002) Interactive effect of chondroitin sulphate C and hyaluronan on fluid movement across rabbit synovium. J Physiol 540(1):271–284PubMedCrossRef
29.
Zurück zum Zitat Frisbie DD, Kawcak CE, Mcllwraith CW, Werpy NM (2009) Evaluation of polysulfated glucosaminoglycans or sodium hyaluronan administered intraarticularly for treatment of horses with experimentally induced osteoarthritis. Am J Vet Res 70:203–209PubMedCrossRef Frisbie DD, Kawcak CE, Mcllwraith CW, Werpy NM (2009) Evaluation of polysulfated glucosaminoglycans or sodium hyaluronan administered intraarticularly for treatment of horses with experimentally induced osteoarthritis. Am J Vet Res 70:203–209PubMedCrossRef
Metadaten
Titel
Viscosupplementation with hyaluronic acid in the treatment for cartilage lesions: a review of current evidence and future directions
verfasst von
Travis E. Clegg
David Caborn
Cyril Mauffrey
Publikationsdatum
01.02.2013
Verlag
Springer-Verlag
Erschienen in
European Journal of Orthopaedic Surgery & Traumatology / Ausgabe 2/2013
Print ISSN: 1633-8065
Elektronische ISSN: 1432-1068
DOI
https://doi.org/10.1007/s00590-012-0940-0

Weitere Artikel der Ausgabe 2/2013

European Journal of Orthopaedic Surgery & Traumatology 2/2013 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.