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The journal of nutrition, health & aging

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28.02.2017

Vitamin B12 and homocysteine associations with gait speed in older adults: The Baltimore Longitudinal Study of Aging

verfasst von: M. L. Vidoni, K. Pettee Gabriel, S. T. Luo, E. M. Simonsick, R. Sue Day

Erschienen in: The journal of nutrition, health & aging | Ausgabe 10/2017

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Abstract

Objectives

This study aimed to assess the independent associations of serum levels of vitamin B12 and plasma concentrations of homocysteine with gait speed decline.

Design, Setting, Participants

This study utilized longitudinal analysis of participants 50 years or older from The Baltimore Longitudinal Study of Aging, N=774.

Measurements

Gait speed (m/s) was assessed using the 6-meter usual pace test. Vitamin B12 and homocysteine concentrations were collected using standard clinical protocols. Linear mixed effects regression was stratified by baseline age category (50-69, 70-79, and ≥80 years old).

Results

Mean follow-up time for the total study sample was 5.4 ± 2.0 years. No association between vitamin B12 and gait speed decline over the follow-up time for any age group was found. Elevated homocysteine concentrations were associated with decline in gait speed after adjustment for covariates (50-69: β= -0.005, p=.057; 70-79: β= -0.013, p<.001, ≥80: β= -0.007, p=.054).

Conclusion

Homocysteine and vitamin B12 are inversely related, yet only homocysteine was associated with gait speed decline in this population of healthy older adults. Given these results, future research should be directed towards investigating the relationship in populations with greater variation in vitamin B12 concentrations and other mechanisms influencing homocysteine concentrations.

Van Kan GA, Rolland Y, Andrieu S, Bauer J, Beauchet O, Bonnefoy M, et al. Gait speed at usual pace as a predictor of adverse outcomes in community-dwelling older people an International Academy on Nutrition and Aging (IANA) Task Force. J Nutr Health Aging. 2009;13(10):881–9.CrossRef

Cesari M, Kritchevsky SB, Penninx BW, Nicklas BJ, Simonsick EM, Newman AB, et al. Prognostic value of usual gait speed in well-functioning older people: results from The Health, Aging and Body Composition Study. J Am Geriatr Soc. 2005;53(10):1675–80.CrossRefPubMed

Studenski S, Perera S, Patel K, Rosano C, Faulkner K, Inzitari M, et al. Gait speed and survival in older adults. JAMA. 2011;305(1):50–8.CrossRefPubMedPubMedCentral

Shumway-Cook A, Guralnik JM, Phillips CL, Coppin AK, Ciol MA, Bandinelli S, et al. Age-associated declines in complex walking task performance: The Walking InCHIANTI Toolkit. J Am Geriatr Soc. 2007;55(1):58–65.CrossRefPubMedPubMedCentral

Baik H, Russell R. Vitamin B12 deficiency in the elderly. Annu Rev Nutr. 1999;19(1):357–77.CrossRefPubMed

Lindenbaum J, Rosenberg IH, Wilson PW, Stabler SP, Allen RH. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr. 1994 Jul;60(1):2–11.CrossRefPubMed

Soumare A, Elbaz A, Ducros V, Tavernier B, Alperovitch A, Tzourio C. Crosssectional association between homocysteine and motor function in the elderly. Neurology. 2006 Sep 26;67(6):985–90.CrossRefPubMed

Rolita L, Holtzer R, Wang C, Lipton RB, Derby CA, Verghese J. Homocysteine and mobility in older adults. J Am Geriatr Soc. 2010;58(3):545–50.CrossRefPubMedPubMedCentral

Ng TP, Aung KC, Feng L, Scherer SC, Yap KB. Homocysteine, folate, vitamin B-12, and physical function in older adults: cross-sectional findings from The Singapore Longitudinal Ageing Study. Am J Clin Nutr. 2012 Dec;96(6):1362–8.CrossRefPubMed

10.

Gerdhem P, Ivaska KK, Isaksson A, Pettersson K, Väänänen HK, Obrant KJ, et al. Associations between homocysteine, bone turnover, BMD, mortality, and fracture risk in elderly women. Journal of Bone and Mineral Research. 2007;22(1):127–34.CrossRefPubMed

11.

Veeranki S, Tyagi SC. Defective homocysteine metabolism: potential implications for skeletal muscle malfunction. Int. J. Mol. Sci. 2013;14(7):15074–91.CrossRefPubMedPubMedCentral

12.

Oberlin BS, Tangney CC, Gustashaw KA, Rasmussen HE. Vitamin B12 deficiency in relation to functional disabilities. Nutrients. 2013;5(11):4462–75.CrossRefPubMedPubMedCentral

13.

Saperstein DS, Barohn RJ. Peripheral neuropathy due to cobalamin deficiency. Current Treatment Options in Neurology. 2002;4(3):197–201.CrossRefPubMed

14.

Leishear K, Boudreau RM, Studenski SA, Ferrucci L, Rosano C, Rekeneire N, et al. Relationship between vitamin B12 and sensory and motor peripheral nerve function in older adults. J Am Geriatr Soc. 2012;60(6):1057–63.CrossRefPubMedPubMedCentral

15.

Weir DG, Scott JM. Brain function in the elderly: role of vitamin B12 and folate. Br Med Bull. 1999;55(3):669–82.CrossRefPubMed

16.

Strotmeyer ES, de Rekeneire N, Schwartz AV, Faulkner KA, Resnick HE, Goodpaster BH, et al. The relationship of reduced peripheral nerve function and diabetes with physical performance in older white and black adults: The Health, Aging, and Body Composition (Health ABC) Study. Diabetes Care. 2008 Sep;31(9):1767–72.CrossRefPubMedPubMedCentral

17.

Van Schoor N, Swart K, Pluijm S, Visser M, Simsek S, Smulders Y, et al. Crosssectional and longitudinal association between homocysteine, vitamin B12 and physical performance in older persons. Eur J Clin Nutr. 2011;66(2):174–81.CrossRefPubMed

18.

Shock NW. Normal human aging: The Baltimore Longitudinal Study of Aging. JAMA. 1986 Feb 21;255(7):960.

19.

Golden E, Emiliano A, Maudsley S, Windham BG, Carlson OD, Egan JM, et al. Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from The Baltimore Longitudinal Study of Aging. PLoS One. 2010;5(4):e10099.CrossRefPubMedPubMedCentral

20.

Kuo HK, Liao KC, Leveille SG, Bean JF, Yen CJ, Chen JH, et al. Relationship of homocysteine levels to quadriceps strength, gait speed, and late-life disability in older adults. J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):434–9.CrossRefPubMedPubMedCentral

21.

Centers for Disease Control and Prevention. Second national report on biochemical indicators of diet and nutrition in the US population: 2012. Atlanta, GA: US Department of Health and Human Services. 2012.

22.

Clarke R, Grimley Evans J, Schneede J, Nexo E, Bates C, Fletcher A, et al. Vitamin B12 and folate deficiency in later life. Age Ageing. 2004 Jan;33(1):34–41.CrossRefPubMed

23.

Tucker JM, Welk GJ, Beyler NK. Physical activity in US adults: compliance with the physical activity guidelines for Americans. Am J Prev Med. 2011;40(4):454–61.CrossRefPubMed

24.

Havlik RJ, Simonsick EM, Sutton-Tyrrell K, Newman A, Danielson ME, Brock DB, et al. Association of physical activity and vascular stiffness in 70-to 79-year-olds: The Health ABC Study. J Aging Phys Act. 2003;11(2):156–66.CrossRef

25.

Panel, NHLBI Obesity Education. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. 1998.

26.

Block G, Woods M, Potosky A, Clifford C. Validation of a self-administered diet history questionnaire using multiple diet records. J Clin Epidemiol. 1990;43(12):1327–35.CrossRefPubMed

27.

Kristal AR, Shattuck AL, Henry HJ, Fowler AS. Rapid assessment of dietary intake of fat, fiber, and saturated fat: Validity of an instrument suitable for community intervention research and nutritional surveillance. Am J Health Promot. 1990;4(4):288–95.CrossRefPubMed

28.

Berndt SI, Carter HB, Landis PK, Tucker KL, Hsieh LJ, Metter EJ, et al. Calcium intake and prostate cancer risk in a long-term aging study: The Baltimore Longitudinal Study of Aging. Urology. 2002;60(6):1118–23.CrossRefPubMed

29.

Clarke R, Sherliker P, Hin H, Nexo E, Hvas AM, Schneede J, et al. Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin. Clin Chem. 2007 May;53(5):963–70.CrossRefPubMed

30.

Kado DM, Bucur A, Selhub J, Rowe JW, Seeman T. Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging. Am J Med. 2002;113(7):537–42.CrossRefPubMed

31.

O’Leary F, Allman-Farinelli M, Petocz P, Samman S. Nutritional status but not vitamin deficiencies are associated with low functional scores. J Aging Res Clin Pract. 2013;2:216-20.

32.

Matteini A, Walston J, Fallin M, Bandeen-Roche K, Kao W, Semba R, et al. Markers of B-vitamin deficiency and frailty in older women. J Nutr Health Aging. 2008;12(5):303–8.CrossRefPubMedPubMedCentral

33.

Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146–56.CrossRefPubMed

34.

Wilkinson ML, Gabriel KP, Luo ST, Simonsick EM, Day RS. Relationship between homocysteine and muscle strength decline: The Baltimore Longitudinal Study of Aging. Forthcoming 2016.

35.

Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ. 2002 Nov 23;325(7374):1202.CrossRefPubMedPubMedCentral

36.

Hassan A, Hunt BJ, O’Sullivan M, Bell R, D’Souza R, Jeffery S, et al. Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction. Brain. 2004 Jan;127(Pt 1):212–9.CrossRefPubMed

37.

Longstreth WT, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke. 1996 Aug;27(8):1274–82.PubMed

38.

Leishear K, Ferrucci L, Lauretani F, Boudreau RM, Studenski SA, Rosano C, et al. Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs. J Gerontol A Biol Sci Med Sci. 2012 May;67(5):537–43.CrossRefPubMed

39.

Resnick HE, Vinik AI, Schwartz AV, Leveille SG, Brancati FL, Balfour J, et al. Independent effects of peripheral nerve dysfunction on lower-extremity physical function in old age: The Women’s Health and Aging Study. Diabetes Care. 2000 Nov;23(11):1642–7.CrossRefPubMed

40.

Clarke R, Bennett D, Parish S, Lewington S, Skeaff M, Eussen SJ, et al. Effects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals. Am J Clin Nutr. 2014 Aug;100(2):657–66.CrossRefPubMedPubMedCentral

41.

Smith AD, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016;36(1).

42.

Swart KM, Ham AC, van Wijngaarden JP, Enneman AW, van Dijk SC, Sohl E, et al. A randomized controlled trial to examine the effect of 2-year vitamin B12 and folic acid supplementation on physical performance, strength, and falling: additional findings from the B-PROOF Study. Calcif Tissue Int. 2015:1–10.

43.

Bazzano LA, Reynolds K, Holder KN, He J. Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA. 2006;296(22):2720–6.CrossRefPubMed

44.

Clarke R, Halsey J, Lewington S, Lonn E, Armitage J, Manson JE, et al. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med. 2010;170(18):1622–31.CrossRefPubMed

45.

Guttormsen A, Svarstad E, Ueland P, Refsum H. Elimination of homocysteine from plasma in subjects with endstage renal failure. Irish J Med Sci. 1995;164(Suppl 15):8–9.

46.

Refsum H, Nurk E, Smith AD, Ueland PM, Gjesdal CG, Bjelland I, et al. The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr. 2006 Jun;136(6 Suppl):1731S–40S.CrossRefPubMed

47.

Kuo HK, Sorond FA, Chen JH, Hashmi A, Milberg WP, Lipsitz LA. The role of homocysteine in multisystem age-related problems: a systematic review. J Gerontol A Biol Sci Med Sci. 2005 Sep;60(9):1190–201.CrossRefPubMed

48.

Berstad P, Konstantinova SV, Refsum H, Nurk E, Vollset SE, Tell GS, et al. Dietary fat and plasma total homocysteine concentrations in 2 adult age groups: The Hordaland Homocysteine Study. Am J Clin Nutr. 2007 Jun;85(6):1598–605.CrossRefPubMed

49.

Li D, Mann NJ, Sinclair AJ. A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. Lipids. 2006;41(1):85–9.CrossRefPubMed

50.

Villegas R, Salim A, Collins M, Flynn A, Perry I. Dietary patterns in middleaged Irish men and women defined by cluster analysis. Public Health Nutr. 2004;7(08):1017–24.CrossRefPubMed

51.

Allen LH. Causes of vitamin B12 and folate deficiency. Food and nutrition bulletin. 2008;29(2 suppl1):S20–34.CrossRefPubMed

52.

National Institutes of Health. Vitamin B12: Dietary Supplement Fact Sheet. http://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/. Updated June, 24 2011

53.

Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press; 1998.

54.

Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. 2012;307(5):491–7.CrossRefPubMed

55.

Shay CM, Ning H, Allen NB, Carnethon MR, Chiuve SE, Greenlund KJ, et al. Status of cardiovascular health in US adults: prevalence estimates from the National Health and Nutrition Examination Surveys (NHANES) 2003-2008. Circulation. 2012 Jan 3;125(1):45–56.CrossRefPubMed

Titel: Vitamin B12 and homocysteine associations with gait speed in older adults: The Baltimore Longitudinal Study of Aging
verfasst von: M. L. Vidoni
K. Pettee Gabriel
S. T. Luo
E. M. Simonsick
R. Sue Day
Publikationsdatum: 28.02.2017
Verlag: Springer Paris
Erschienen in: The journal of nutrition, health & aging / Ausgabe 10/2017
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-017-0893-4

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Vitamin B12 and homocysteine associations with gait speed in older adults: The Baltimore Longitudinal Study of Aging

Abstract

Objectives

Design, Setting, Participants

Measurements

Results

Conclusion

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Abstract

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Measurements

Results

Conclusion

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