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Osteoporosis International

Erschienen in:

01.07.2008 | Original Article

Vitamin D-binding protein gene microsatellite polymorphism influences BMD and risk of fractures in men

verfasst von: Z. H. Al-oanzi, S. P. Tuck, S. S. Mastana, G. D. Summers, D. B. Cook, R. M. Francis, H. K. Datta

Erschienen in: Osteoporosis International | Ausgabe 7/2008

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Abstract

Summary

Here we report the results of a vitamin D-binding protein gene microsatellite polymorphism study in 170 men, comprising healthy male subjects and men with osteoporosis-related symptomatic vertebral fractures. We confirm the results of an earlier study in a different cohort, showing relationship between certain genotypes of (TAAA_n)-Alu repeats and reduced BMD and vertebral fractures.

Introduction

Vitamin D-binding protein (DBP) plays a critical role in the transport and metabolism of metabolites of vitamin D, including the key calciotropic hormone 1α,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃).

Methods

We have investigated intra-intronic variable tandem (TAAA)n-Alu repeat expansion in the DBP gene in 170 men, comprising healthy male subjects and men with idiopathic osteoporosis and low trauma fractures.

Results and conclusions

The predominant DBP-Alu genotype in the control subjects was 10/10 (frequency 0.421), whereas the frequency of this genotype in men with osteoporosis was 0.089. DBP-Alu alleles *10, *8 and *9, respectively, were the three commonest in both healthy subjects and men with osteoporosis. Allele *10 was associated with a lower risk of osteoporosis (OR 0.39, 95% CI 0.25–0.64; p < 0.0005), as was allele *11 (odds ratio 0.09, 95% CI 0.01–0.67; p < 0.007). Logistic regression gave similar results, showing that individuals with genotype 10/10 and 19–20 repeats (genotypes 9/10, 9/11, 10/10,) are protected from fracture or osteoporosis. Overall, there was a relationship between DBP Alu genotype and BMD, suggesting that DBP-Alu genotype may influence fracture risk. This effect may be mediated by changes in the circulating concentrations of DBP which influences free concentrations of vitamin D.

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Titel: Vitamin D-binding protein gene microsatellite polymorphism influences BMD and risk of fractures in men
verfasst von: Z. H. Al-oanzi
S. P. Tuck
S. S. Mastana
G. D. Summers
D. B. Cook
R. M. Francis
H. K. Datta
Publikationsdatum: 01.07.2008
Verlag: Springer-Verlag
Erschienen in: Osteoporosis International / Ausgabe 7/2008
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-007-0516-8

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Vitamin D-binding protein gene microsatellite polymorphism influences BMD and risk of fractures in men

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