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ADHD Attention Deficit and Hyperactivity Disorders

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26.10.2018 | Review Article

Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): a meta-analysis

verfasst von: Evangelia Kotsi, Elisavet Kotsi, Despina N. Perrea

Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders | Ausgabe 3/2019

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Abstract

The aim of this article was to assess the differences in serum 25(OH)D levels between children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy controls. We used the PubMed (1966–2017), Scopus (2004–2017), ClinicalTrials.gov (2008–2017), Cochrane Central Register of Controlled Trials CENTRAL (2000–2017), and Google Scholar (2004–2017) databases. Statistical meta-analysis was performed with RevMan 5.3. Εight studies were finally included in the present meta-analysis with a total number of 11,324 children. Among them, 2655 were diagnosed with ADHD, while the remaining 8669 were recruited as healthy controls. All eight trials reported significantly lower serum concentrations of 25(OH)D in patients diagnosed with ADHD compared to healthy controls. The pooled data showed that there was a significant difference between the ADHD group and the control group (SMD = − 0.73, 95% CI [− 1.00, − 0.46]). The systematic review and meta-analysis of observational studies demonstrated an inverse association between serum 25(OH)D and young patients with ADHD. Large cohort studies are required to investigate whether vitamin D-deficient infants are more likely to develop ADHD in the future. Also, whether children with ADHD should be supplemented with higher doses of vitamin D3 remains to be confirmed through long-term controlled clinical trials.

Vitamin D as a therapeutic adjunct in the stimulant treatment of ADHD. https://clinicaltrials.gov/ct2/show/NCT03103750?term=vitamin+D&cond=ADHD&rank=1.

Ascherio A, Munger KL, Simon KC (2010) Vitamin D and multiple sclerosis. Lancet Neurol 9(6):599–612PubMedCrossRef

Autier P et al (2014) Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol 2(1):76–89PubMedCrossRef

Avcil S et al (2017) Vitamin D deficiency and a blunted parathyroid hormone response in children with attention-deficit/hyperactivity disorder. Clin Lab 63(3):435–443PubMed

Bala KA et al (2016) Hormone disorder and vitamin deficiency in attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs). J Pediatr Endocrinol Metab 29(9):1077–1082PubMedCrossRef

Bener A et al (2014) Higher prevalence of iron deficiency as strong predictor of attention deficit hyperactivity disorder in children. Ann Med Health Sci Res 4(Suppl 3):S291–S297PubMedPubMedCentralCrossRef

Berridge MJ (2018) Vitamin D deficiency: infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder, autism, and schizophrenia). Am J Physiol Cell Physiol 314(2):C135–C151PubMedCrossRef

Braegger C et al (2013) Vitamin D in the healthy European paediatric population. J Pediatr Gastroenterol Nutr 56(6):692–701PubMedCrossRef

Carvalho JTG et al (2017) Cholecalciferol decreases inflammation and improves vitamin D regulatory enzymes in lymphocytes in the uremic environment: a randomized controlled pilot trial. PLoS ONE 12(6):e0179540PubMedPubMedCentralCrossRef

Cashman KD et al (2016) Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 103(4):1033–1044PubMedPubMedCentralCrossRef

Cass WA, Smith MP, Peters LE (2006) Calcitriol protects against the dopamine- and serotonin-depleting effects of neurotoxic doses of methamphetamine. Ann N Y Acad Sci 1074:261–271PubMedCrossRef

Childress AC, Sallee FR (2014) Attention-deficit/hyperactivity disorder with inadequate response to stimulants: approaches to management. CNS Drugs 28(2):121–129PubMedCrossRef

Coghill D, Hodgkins P (2016) Health-related quality of life of children with attention-deficit/hyperactivity disorder versus children with diabetes and healthy controls. Eur Child Adolesc Psychiatry 25(3):261–271PubMedCrossRef

Daraki V et al (2018) High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother–child cohort, Crete, Greece. Eur Child Adolesc Psychiatry 27(1):79–88PubMedCrossRef

Dawodu A, Nath R (2011) High prevalence of moderately severe vitamin D deficiency in preterm infants. Pediatr Int 53(2):207–210PubMedCrossRef

DerSimonian R, Kacker R (2007) Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials 28(2):105–114PubMedCrossRef

Dopfner M et al (2015) Long-term course of ADHD symptoms from childhood to early adulthood in a community sample. Eur Child Adolesc Psychiatry 24(6):665–673PubMedCrossRef

Doshi JA et al (2012) Economic impact of childhood and adult attention-deficit/hyperactivity disorder in the United States. J Am Acad Child Adolesc Psychiatry 51(10):990–1002PubMedCrossRef

Eyles DW et al (2009) Developmental vitamin D deficiency causes abnormal brain development. Psychoneuroendocrinology 34(Suppl 1):S247–S257PubMedCrossRef

Eyles D, Burne T, McGrath J (2011) Vitamin D in fetal brain development. Semin Cell Dev Biol 22(6):629–636PubMedCrossRef

Eyles DW, Burne TH, McGrath JJ (2013) Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease. Front Neuroendocrinol 34(1):47–64PubMedCrossRef

Eyles DW et al (2014) Intracellular distribution of the vitamin D receptor in the brain: comparison with classic target tissues and redistribution with development. Neuroscience 268:1–9PubMedCrossRef

Feldman HM, Reiff MI (2014) Clinical practice. Attention deficit-hyperactivity disorder in children and adolescents. N Engl J Med 370(9):838–846PubMedCrossRef

Fleet JC et al (2012) Vitamin D and cancer: a review of molecular mechanisms. Biochem J 441(1):61–76PubMedPubMedCentralCrossRef

Gallo EF, Posner J (2016) Moving towards causality in attention-deficit hyperactivity disorder: overview of neural and genetic mechanisms. Lancet Psychiatry 3(6):555–567PubMedPubMedCentralCrossRef

Garipardic M et al (2017) Association of attention deficit hyperactivity disorder and autism spectrum disorders with mean platelet volume and vitamin D. Med Sci Monit 23:1378–1384PubMedPubMedCentralCrossRef

Goksugur SB et al (2014) Vitamin D status in children with attention-deficit-hyperactivity disorder. Pediatr Int 56(4):515–519PubMedCrossRef

Gustafsson P et al (2015) Vitamin D status at birth and future risk of attention deficit/hyperactivity disorder (ADHD). PLoS ONE 10(10):e0140164PubMedPubMedCentralCrossRef

Hawes JE et al (2015) Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse. Behav Brain Res 286:192–200PubMedCrossRef

Health Quality O (2010) Clinical utility of vitamin d testing: an evidence-based analysis. Ont Health Technol Assess Ser 10(2):1–93

Holick MF (1987) Photosynthesis of vitamin D in the skin: effect of environmental and life-style variables. Fed Proc 46(5):1876–1882PubMed

Holick MF (2007) Vitamin D deficiency. N Engl J Med 357(3):266–281CrossRef

Holton KF et al (2018) Evaluation of dietary intake in children and college students with and without attention-deficit/hyperactivity disorder. Nutr Neurosci. https://doi.org/10.1080/1028415X.2018.1427661 CrossRefPubMed

Humble MB, Gustafsson S, Bejerot S (2010) Low serum levels of 25-hydroxyvitamin D (25-OHD) among psychiatric out-patients in Sweden: relations with season, age, ethnic origin and psychiatric diagnosis. J Steroid Biochem Mol Biol 121(1–2):467–470PubMedCrossRef

Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Ross AC, Taylor CL, Yaktine AL et al (eds) (2011) Dietary reference intakes for calcium and vitamin D. National Academies Press, Washington

Kamal M, Bener A, Ehlayel MS (2014) Is high prevalence of vitamin D deficiency a correlate for attention deficit hyperactivity disorder? Atten Defic Hyperact Disord 6(2):73–78PubMedCrossRef

Kaneko I et al (2015) 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D. FASEB J 29(9):4023–4035PubMedCrossRef

Kesby JP et al (2013) Altered dopamine ontogeny in the developmentally vitamin D deficient rat and its relevance to schizophrenia. Front Cell Neurosci 7:111PubMedPubMedCentralCrossRef

Klein RG et al (2012) Clinical and functional outcome of childhood attention-deficit/hyperactivity disorder 33 years later. Arch Gen Psychiatry 69(12):1295–1303PubMedPubMedCentralCrossRef

Lawrence DW, Sharma B (2016) A review of the neuroprotective role of vitamin D in traumatic brain injury with implications for supplementation post-concussion. Brain Inj 30(8):960–968PubMedCrossRef

Le Goff C et al (2015) Measurement of circulating 25-hydroxyvitamin D: a historical review. Pract Lab Med 2:1–14PubMedPubMedCentralCrossRef

Le HH et al (2014) Economic impact of childhood/adolescent ADHD in a European setting: the Netherlands as a reference case. Eur Child Adolesc Psychiatry 23(7):587–598PubMedCrossRef

Leary PF et al (2017) Effect of Latitude on Vitamin D Levels. J Am Osteopath Assoc 117(7):433–439PubMedCrossRef

Liberati A et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol 62(10):e1–e34CrossRefPubMed

Meyer T et al (2017) Attention deficit-hyperactivity disorder is associated with reduced blood pressure and serum vitamin D levels: results from the nationwide German Health Interview and Examination Survey for Children and Adolescents (KiGGS). Eur Child Adolesc Psychiatry 26(2):165–175PubMedCrossRef

Mohammadpour N et al (2018) Effect of vitamin D supplementation as adjunctive therapy to methylphenidate on ADHD symptoms: a randomized, double blind, placebo-controlled trial. Nutr Neurosci 21(3):202–209PubMedCrossRef

Morales E et al (2015) Vitamin D in pregnancy and attention deficit hyperactivity disorder-like symptoms in childhood. Epidemiology 26(4):458–465PubMedCrossRef

Mossin MH et al (2017) Inverse associations between cord vitamin D and attention deficit hyperactivity disorder symptoms: a child cohort study. Aust N Z J Psychiatry 51(7):703–710PubMedCrossRef

Mulraney M et al (2017) ADHD symptoms and quality of life across a 12-month period in children with ADHD: a longitudinal study. J Atten Disord. https://doi.org/10.1177/1087054717707046 CrossRefPubMed

Partonen T (1998) Vitamin D and serotonin in winter. Med Hypotheses 51(3):267–268PubMedCrossRef

Pludowski P et al (2013) Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—a review of recent evidence. Autoimmun Rev 12(10):976–989PubMedCrossRef

Schoenrock SA, Tarantino LM (2016) Developmental vitamin D deficiency and schizophrenia: the role of animal models. Genes Brain Behav 15(1):45–61PubMedPubMedCentralCrossRef

Shang-Guan LL, Zhao YR (2015) Serum levels of 25-hydroxyvitamin D in children with attention deficit hyperactivity disorder. Zhongguo Dang Dai Er Ke Za Zhi 17(8):837–840PubMed

Sharif MR et al (2015) The relationship between serum vitamin D level and attention deficit hyperactivity disorder. Iran J Child Neurol 9(4):48–53PubMedPubMedCentral

Shin JS et al (2010) Vitamin D effects on pregnancy and the placenta. Placenta 31(12):1027–1034PubMedPubMedCentralCrossRef

Snellman G et al (2010) Determining vitamin D status: a comparison between commercially available assays. PLoS ONE 5(7):e11555PubMedPubMedCentralCrossRef

Souza JP, Pileggi C, Cecatti JG (2007) Assessment of funnel plot asymmetry and publication bias in reproductive health meta-analyses: an analytic survey. Reprod Health 4:3PubMedPubMedCentralCrossRef

Stang A (2010) Critical evaluation of the Newcastle–Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25(9):603–605CrossRef

Strom M et al (2014) Vitamin D measured in maternal serum and offspring neurodevelopmental outcomes: a prospective study with long-term follow-up. Ann Nutr Metab 64(3–4):254–261PubMedCrossRef

Subcommittee on Attention-Deficit/Hyperactivity Disorder et al (2011) ADHD: clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Pediatrics 128(5):1007–1022CrossRef

Telford C et al (2013) Estimating the costs of ongoing care for adolescents with attention-deficit hyperactivity disorder. Soc Psychiatry Psychiatr Epidemiol 48(2):337–344PubMedCrossRef

Turner KM et al (2013) Cognitive performance and response inhibition in developmentally vitamin D (DVD)-deficient rats. Behav Brain Res 242:47–53PubMedCrossRef

Wacker M, Holick MF (2013) Vitamin D—effects on skeletal and extraskeletal health and the need for supplementation. Nutrients 5(1):111–148PubMedPubMedCentralCrossRef

Wallace AM et al (2010) Measurement of 25-hydroxyvitamin D in the clinical laboratory: current procedures, performance characteristics and limitations. Steroids 75(7):477–488PubMedCrossRef

Wang Y, Zhu J, DeLuca HF (2012) Where is the vitamin D receptor? Arch Biochem Biophys 523(1):123–133PubMedCrossRef

Wang T et al (2016) Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder: a systematic review and meta-analysis. Eur Child Adolesc Psychiatry 25(4):341–350PubMedCrossRef

Webb AR, Kline L, Holick MF (1988) Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 67(2):373–378PubMedCrossRef

Titel: Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): a meta-analysis
verfasst von: Evangelia Kotsi
Elisavet Kotsi
Despina N. Perrea
Publikationsdatum: 26.10.2018
Verlag: Springer Vienna
Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders / Ausgabe 3/2019
Print ISSN: 1866-6116
Elektronische ISSN: 1866-6647
DOI: https://doi.org/10.1007/s12402-018-0276-7

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