Vitamin D status in patients with cirrhosis of the liver and their relatives—A case control study from North India
- 08.02.2017
- Original Article
Erschienen in:
- Verfasst von
- Ravikant Kumar
- Pavan Kumar
- Kandarp Nath Saxena
- Manjul Mishra
- Vivek Kumar Mishra
- Anju Kumari
- Manisha Dwivedi
- Sri Prakash Misra
- Erschienen in
- Indian Journal of Gastroenterology | Ausgabe 1/2017
Abstract
Background and Aim
Liver diseases interfere with the production of the metabolites of vitamin D required for activation, thus resulting in abnormal calcium and bone metabolism. Previous studies show inconsistent results of vitamin D level in non-cholestatic liver diseases. Our aim was to determine the prevalence of vitamin D insufficiency in cirrhosis as compared to apparently normal relatives and its relationship with etiology and severity.
Methods
One hundred and sixty cirrhotic patients attending the Department of Gastroenterology and Hepatology, M L N Medical College, Allahabad, were enrolled, and 25-hydroxy vitamin D [25(OH)D] and calcium levels assessed. Vitamin D status was graded as insufficiency (20–30 ng/mL), deficiency (<20 ng/mL), and severe deficiency (<7 ng/mL). 25(OH)D levels of patients were compared with those of their healthy family members.
Results
Forty-six percent of the normal population had 25(OH)D inadequacy, whereas 51.85% of patients with cirrhosis had 25(OH)D deficiency, and 28.12% had insufficiency. Thus, 80% of patients with cirrhosis of the liver had some form of vitamin D inadequacy. 12.5% of cirrhotics had severe vitamin D deficiency. Serum calcium (Ca++) was not significantly different between the patients and control group. The etiology of cirrhosis had no relation with vitamin D levels. Prevalence of deficiency and insufficiency increased with increasing age and mean Child-Turcotte-Pugh and model for end-stage liver disease scores.
Conclusion
Vitamin D insufficiency is highly prevalent in patients with cirrhosis irrespective of etiology and significantly more common than their healthy relatives. Measurement of 25(OH) vitamin D and replacement may be considered as part of the overall management of patients with cirrhosis of the liver as well as apparently healthy individuals.
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- Titel
- Vitamin D status in patients with cirrhosis of the liver and their relatives—A case control study from North India
- Verfasst von
-
Ravikant Kumar
Pavan Kumar
Kandarp Nath Saxena
Manjul Mishra
Vivek Kumar Mishra
Anju Kumari
Manisha Dwivedi
Sri Prakash Misra
- Publikationsdatum
- 08.02.2017
- Verlag
- Springer India
- Erschienen in
-
Indian Journal of Gastroenterology / Ausgabe 1/2017
Print ISSN: 0254-8860
Elektronische ISSN: 0975-0711 - DOI
- https://doi.org/10.1007/s12664-017-0727-7
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