Erschienen in:

23.09.2023 | Original Contribution

Vitamin D₃ supplementation shapes the composition of gut microbiota and improves some obesity parameters induced by high-fat diet in mice

verfasst von: Lian Xiang, Tingwan Du, Jingjing Zhang, Yuanfan Zhang, Yanqiu Zhou, Yueying Zhao, Yong Zhou, Ling Ma

Erschienen in: European Journal of Nutrition | Ausgabe 1/2024

Abstract

Purpose

Individuals with vitamin D (VD) insufficiency have a greater tendency to develop obesity and have increased systemic inflammation. Gut microbiota are involved in the regulation of host inflammation and energy metabolism, which plays a role in the pathogenesis of obesity. Thus, we aimed to evaluate the effects of different doses of VD₃ on body weight, serum lipids, inflammatory factors, and intestinal barrier function in obese mice and to explore the regulatory effect of VD₃ on gut microbiota in obese mice.

Methods

Male C57BL/6 J mice received a normal chow diet (NCD, 10% fat) or high-fat diet (HFD, 60% fat) to induce obesity within 10 weeks. Then, HFD mice were supplemented with 5650, 8475, or 11,300 IU VD₃/kg diet for 8 weeks. Finally, 16 s rRNA analysis was performed to analyze gut microbiota composition in cecal contents. In addition, body weight, serum lipids, inflammatory factors, and intestinal barrier function were analyzed.

Results

VD₃ supplementation reduced body weight and the levels of TG, TC, HDL-C, TNF-α, IL-1β and LPS, and increased ZO-1 in HFD-fed mice. Moreover, it increased α-diversity, reduced F/B ratio and altered microbiota composition by increasing relative abundance of Bacteroidetes, Proteobacteria, Desulfovibrio, Dehalobacterium, Odoribacter, and Parabacteroides and reducing relative abundance of Firmicutes and Ruminococcus. There were significant differences between HFD and NCD groups in several metabolic pathways, including endotoxin biosynthesis, tricarboxylic acid cycle, lipid synthesis and metabolism, and glycolysis.

Conclusions

Low, medium, and high doses of VD₃ inhibited weight gain, reduced levels of blood lipids and inflammatory factors, and improved endotoxemia and gut barrier function in obese mice. It also increased the α-diversity of gut microbiota in obese mice and reduced the relative abundance of some intestinal pathogenic bacteria, increased the relative abundance of some beneficial bacteria, and corrected the intestinal flora disorder of obese mice, with the low- and high-dose groups showing better effects than the medium-dose group.

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Titel: Vitamin D3 supplementation shapes the composition of gut microbiota and improves some obesity parameters induced by high-fat diet in mice
verfasst von: Lian Xiang
Tingwan Du
Jingjing Zhang
Yuanfan Zhang
Yanqiu Zhou
Yueying Zhao
Yong Zhou
Ling Ma
Publikationsdatum: 23.09.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 1/2024
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-023-03246-1

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Erneut Hinweise für Neuroprotektion durch Gürtelroseimpfung

29.04.2025
Herpes-zoster-Impfung
Nachrichten

Ergebnisse eines kürzlich publizierten „natürlichen Experiments“ in Wales legten nahe, dass eine Herpes-Zoster-Impfung das Demenzrisiko senkt. Jetzt hat das Studienteam ähnliche Daten aus Australien publiziert, die in die gleiche Richtung zeigen. Offene Fragen bleiben allerdings so oder so.

Harnwegsinfekt mit üblem Verlauf: Das sind die Anzeichen

29.04.2025
Harnwegsinfektionen
Nachrichten

Harnwegsinfekte können schwer und sogar tödlich verlaufen. Welche Patienten gefährdet sind, ist im Zuge einer Metaanalyse untersucht worden.

Leben statt zu Überleben: Post-Intensive-Care-Syndrom

Immer mehr Menschen überleben kritische Erkrankungen. Aber Beatmung, Sedierung und die Eindrücke der Intensivstation hinterlassen Spuren. Das Post-Intensive-Care-Syndrom kann die Folge sein. Es ist nicht nur eine Herausforderung für Kliniken, sondern auch Hausarztpraxen. Mit Allgemeinmediziner Prof. Dr. med. Konrad Schmidt sprechen wir in dieser Folge darüber, wie die Überlebenden wieder ins Leben finden können.

Update Innere Medizin

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Springer Medizin

Vitamin D₃ supplementation shapes the composition of gut microbiota and improves some obesity parameters induced by high-fat diet in mice

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Erneut Hinweise für Neuroprotektion durch Gürtelroseimpfung

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Update Innere Medizin

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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