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Erschienen in: Cardiovascular Drugs and Therapy 6/2014

01.12.2014 | ORIGINAL ARTICLE

Vitamin E Supplementation and Mortality in Healthy People: A Meta-Analysis of Randomised Controlled Trials

verfasst von: Andrea J. Curtis, Michael Bullen, Loretta Piccenna, John J. McNeil

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 6/2014

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Abstract

Purpose

To evaluate the effect of oral vitamin E supplementation on all-cause mortality in apparently healthy people.

Methods

A systematic review and meta-analysis was conducted on randomised controlled trials (RCTs) with ≥6 months of follow up investigating the effect of vitamin E supplementation on healthy adults in developed countries. Electronic databases (MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials) and reference lists of trial reports were searched for RCTs published between 1966 and June 2012. Three investigators assessed eligibility of identified trials. Disagreements were resolved by consensus. Two investigators independently extracted data according to the criteria.

Results

There were 18 RCTs identified with 142,219 apparently healthy participants (71,116 in vitamin E intervention groups and 71,103 in control groups) that were included in the final analysis. Fixed effect and random effects analysis of the 18 trials revealed that supplementation with vitamin E was not associated with all-cause mortality (relative risk 1.01, 95 % confidence interval 0.97 – 1.05, p = 0.65). Subgroup analyses by type of vitamin E (natural or synthetic), dose or duration of exposure, study design or quality, and pre-specified mortality outcome showed no association with all-cause mortality.

Conclusions

The evidence from pooled analysis of 18 randomised controlled trials undertaken in apparently healthy people shows no effect of vitamin E supplementation at a dose of 23–800 IU/day on all-cause mortality.
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Literatur
1.
Zurück zum Zitat Dutta A, Dutta SK. Vitamin E and its role in the prevention of atherosclerosis and carcinogenesis: a review. J Am Coll Nutr. 2003;22(4):258–68.PubMedCrossRef Dutta A, Dutta SK. Vitamin E and its role in the prevention of atherosclerosis and carcinogenesis: a review. J Am Coll Nutr. 2003;22(4):258–68.PubMedCrossRef
2.
Zurück zum Zitat Stampfer MJ, Hennekens CH, Manson JE, et al. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med. 1993;328(20):1444–9.PubMedCrossRef Stampfer MJ, Hennekens CH, Manson JE, et al. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med. 1993;328(20):1444–9.PubMedCrossRef
3.
Zurück zum Zitat Rimm EB, Stampfer MJ, Ascherio A, et al. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 1993;328(20):1450–6.PubMedCrossRef Rimm EB, Stampfer MJ, Ascherio A, et al. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 1993;328(20):1450–6.PubMedCrossRef
4.
Zurück zum Zitat Vivekananthan DP, Penn MS, Sapp SK, et al. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet. 2003;361(9374):2017–23.PubMedCrossRef Vivekananthan DP, Penn MS, Sapp SK, et al. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet. 2003;361(9374):2017–23.PubMedCrossRef
5.
Zurück zum Zitat Eidelman RS, Hollar D, Hebert PR, et al. Randomized trials of vitamin E in the treatment and prevention of cardiovascular disease. Arch Intern Med. 2004;164(14):1552–6.PubMedCrossRef Eidelman RS, Hollar D, Hebert PR, et al. Randomized trials of vitamin E in the treatment and prevention of cardiovascular disease. Arch Intern Med. 2004;164(14):1552–6.PubMedCrossRef
6.
Zurück zum Zitat Myung SK, Ju W, Cho B, et al. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. BMJ (Clinical research ed). 2013;346:f10. Myung SK, Ju W, Cho B, et al. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. BMJ (Clinical research ed). 2013;346:f10.
7.
Zurück zum Zitat Jiang L, Yang KH, Tian JH, et al. Efficacy of antioxidant vitamins and selenium supplement in prostate cancer prevention: a meta-analysis of randomized controlled trials. Nutr Cancer. 2010;62(6):719–27.PubMedCrossRef Jiang L, Yang KH, Tian JH, et al. Efficacy of antioxidant vitamins and selenium supplement in prostate cancer prevention: a meta-analysis of randomized controlled trials. Nutr Cancer. 2010;62(6):719–27.PubMedCrossRef
8.
Zurück zum Zitat Bjelakovic G, Nikolova D, Simonetti RG, et al. Systematic review: primary and secondary prevention of gastrointestinal cancers with antioxidant supplements. Aliment Pharmacol Ther. 2008;28(6):689–703.PubMedCrossRef Bjelakovic G, Nikolova D, Simonetti RG, et al. Systematic review: primary and secondary prevention of gastrointestinal cancers with antioxidant supplements. Aliment Pharmacol Ther. 2008;28(6):689–703.PubMedCrossRef
9.
Zurück zum Zitat Cortes-Jofre M, Rueda JR, Corsini-Munoz G, et al. Drugs for preventing lung cancer in healthy people. The Cochrane database of systematic reviews. 2012;10:CD002141.PubMed Cortes-Jofre M, Rueda JR, Corsini-Munoz G, et al. Drugs for preventing lung cancer in healthy people. The Cochrane database of systematic reviews. 2012;10:CD002141.PubMed
10.
Zurück zum Zitat Farina N, Isaac MG, Clark AR, et al. Vitamin E for Alzheimer’s dementia and mild cognitive impairment. The Cochrane database of systematic reviews. 2012;11:CD002854.PubMed Farina N, Isaac MG, Clark AR, et al. Vitamin E for Alzheimer’s dementia and mild cognitive impairment. The Cochrane database of systematic reviews. 2012;11:CD002854.PubMed
11.
Zurück zum Zitat Schurks M, Glynn RJ, Rist PM, et al. Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ (Clinical research ed). 2010;341:c5702.CrossRef Schurks M, Glynn RJ, Rist PM, et al. Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ (Clinical research ed). 2010;341:c5702.CrossRef
12.
Zurück zum Zitat Miller 3rd ER, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142(1):37–46.PubMedCrossRef Miller 3rd ER, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142(1):37–46.PubMedCrossRef
13.
Zurück zum Zitat Bjelakovic G, Nikolova D, Gluud LL, et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA :J Am Med Assoc. 2007;297(8):842–57.CrossRef Bjelakovic G, Nikolova D, Gluud LL, et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA :J Am Med Assoc. 2007;297(8):842–57.CrossRef
14.
Zurück zum Zitat Bjelakovic G, Nikolova D, Gluud LL, et al. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. The Cochrane database of systematic reviews. 2012;3:CD007176.PubMed Bjelakovic G, Nikolova D, Gluud LL, et al. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. The Cochrane database of systematic reviews. 2012;3:CD007176.PubMed
15.
Zurück zum Zitat Bjelakovic G, Nikolova D, Gluud C. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with Beta-carotene, vitamin a, and vitamin e singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS One. 2013;8(9):e74558.PubMedCentralPubMedCrossRef Bjelakovic G, Nikolova D, Gluud C. Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with Beta-carotene, vitamin a, and vitamin e singly or in different combinations on all-cause mortality: do we have evidence for lack of harm? PLoS One. 2013;8(9):e74558.PubMedCentralPubMedCrossRef
16.
Zurück zum Zitat Chun OK, Floegel A, Chung SJ, et al. Estimation of antioxidant intakes from diet and supplements in U.S. adults. J nutri. 2010;140(2):317–24.CrossRef Chun OK, Floegel A, Chung SJ, et al. Estimation of antioxidant intakes from diet and supplements in U.S. adults. J nutri. 2010;140(2):317–24.CrossRef
17.
Zurück zum Zitat Yang M, Chung SJ, Chung CE, et al. Estimation of total antioxidant capacity from diet and supplements in US adults. British J nutri. 2011;106(2):254–63.CrossRef Yang M, Chung SJ, Chung CE, et al. Estimation of total antioxidant capacity from diet and supplements in US adults. British J nutri. 2011;106(2):254–63.CrossRef
18.
Zurück zum Zitat Tilburt JC, Emanuel EJ, Miller FG. Does the evidence make a difference in consumer behavior? Sales of supplements before and after publication of negative research results. J Gen Intern Med. 2008;23(9):1495–8.PubMedCentralPubMedCrossRef Tilburt JC, Emanuel EJ, Miller FG. Does the evidence make a difference in consumer behavior? Sales of supplements before and after publication of negative research results. J Gen Intern Med. 2008;23(9):1495–8.PubMedCentralPubMedCrossRef
19.
Zurück zum Zitat Bailey RL, Gahche JJ, Miller PE, et al. Why US adults use dietary supplements. JAMA internal medicine. 2013;173(5):355–61.PubMedCrossRef Bailey RL, Gahche JJ, Miller PE, et al. Why US adults use dietary supplements. JAMA internal medicine. 2013;173(5):355–61.PubMedCrossRef
20.
Zurück zum Zitat MacLennan AH, Wilson DH, Taylor AW. Prevalence and cost of alternative medicine in Australia. Lancet. 1996;347(9001):569–73.PubMedCrossRef MacLennan AH, Wilson DH, Taylor AW. Prevalence and cost of alternative medicine in Australia. Lancet. 1996;347(9001):569–73.PubMedCrossRef
21.
Zurück zum Zitat MacLennan AH, Wilson DH, Taylor AW. The escalating cost and prevalence of alternative medicine. Prev Med. 2002;35(2):166–73.PubMedCrossRef MacLennan AH, Wilson DH, Taylor AW. The escalating cost and prevalence of alternative medicine. Prev Med. 2002;35(2):166–73.PubMedCrossRef
22.
Zurück zum Zitat MacLennan AH, Myers SP, Taylor AW. The continuing use of complementary and alternative medicine in South Australia: costs and beliefs in 2004. Med J Aust. 2006;184(1):27–31.PubMed MacLennan AH, Myers SP, Taylor AW. The continuing use of complementary and alternative medicine in South Australia: costs and beliefs in 2004. Med J Aust. 2006;184(1):27–31.PubMed
23.
Zurück zum Zitat Xue CC, Zhang AL, Lin V, et al. Complementary and alternative medicine use in Australia: a national population-based survey. J altern comp med(New York, NY). 2007;13(6):643–50.CrossRef Xue CC, Zhang AL, Lin V, et al. Complementary and alternative medicine use in Australia: a national population-based survey. J altern comp med(New York, NY). 2007;13(6):643–50.CrossRef
24.
Zurück zum Zitat Williamson M, Tudball J, Toms M, et al. Information Use and Needs of Complementary Medicines Users. In: National Prescribing Service S, ed., 2008. Williamson M, Tudball J, Toms M, et al. Information Use and Needs of Complementary Medicines Users. In: National Prescribing Service S, ed., 2008.
25.
Zurück zum Zitat Morgan TK, Williamson M, Pirotta M, et al. A national census of medicines use: a 24-hour snapshot of Australians aged 50 years and older. Med J Aust. 2012;196(1):50–3.PubMedCrossRef Morgan TK, Williamson M, Pirotta M, et al. A national census of medicines use: a 24-hour snapshot of Australians aged 50 years and older. Med J Aust. 2012;196(1):50–3.PubMedCrossRef
26.
Zurück zum Zitat Brownie S. Predictors of dietary and health supplement use in older Australians. The Australian journal of advanced nursing : a quarterly publication of the Royal Australian Nursing Federation. 2006;23(3):26–32. Brownie S. Predictors of dietary and health supplement use in older Australians. The Australian journal of advanced nursing : a quarterly publication of the Royal Australian Nursing Federation. 2006;23(3):26–32.
27.
Zurück zum Zitat 27. Australian Bureau of Statistics. Australian Health Survey: Health service usage and health related actions, 2011–12, cat. no. 4364.0.55.002. Canberra: ABS; 2013. 27. Australian Bureau of Statistics. Australian Health Survey: Health service usage and health related actions, 2011–12, cat. no. 4364.0.55.002. Canberra: ABS; 2013.
28.
Zurück zum Zitat Druesne-Pecollo N, Latino-Martel P, Norat T, et al. Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials. Int j canc J intern du canc. 2010;127(1):172–84.CrossRef Druesne-Pecollo N, Latino-Martel P, Norat T, et al. Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials. Int j canc J intern du canc. 2010;127(1):172–84.CrossRef
29.
Zurück zum Zitat Gee PT. Unleashing the untold and misunderstood observations on vitamin E. Genes nutri. 2011;6(1):5–16.CrossRef Gee PT. Unleashing the untold and misunderstood observations on vitamin E. Genes nutri. 2011;6(1):5–16.CrossRef
30.
Zurück zum Zitat Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ (Clinical research ed). 2009;339:b2535.CrossRef Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ (Clinical research ed). 2009;339:b2535.CrossRef
31.
Zurück zum Zitat Human Development Report – The Rise of the South: Human Progress in a Diverse World. 2013 Human Development Report – The Rise of the South: Human Progress in a Diverse World. 2013
32.
Zurück zum Zitat The Cochrane Collaboration, editor. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 ed: Cochrane Collaboration 2011 The Cochrane Collaboration, editor. Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 ed: Cochrane Collaboration 2011
33.
Zurück zum Zitat Borenstein M, Hedges L, Higgins J, et al. Comprehensive Meta-analysis Version 2. Englewood NJ: Biostat; 2005. Borenstein M, Hedges L, Higgins J, et al. Comprehensive Meta-analysis Version 2. Englewood NJ: Biostat; 2005.
34.
Zurück zum Zitat Collins EG, Edwin Langbein W, Orebaugh C, et al. PoleStriding exercise and vitamin E for management of peripheral vascular disease. Med Sci Sports Exerc. 2003;35(3):384–93.PubMedCrossRef Collins EG, Edwin Langbein W, Orebaugh C, et al. PoleStriding exercise and vitamin E for management of peripheral vascular disease. Med Sci Sports Exerc. 2003;35(3):384–93.PubMedCrossRef
35.
Zurück zum Zitat Manning PJ, Sutherland WH, Williams SM, et al. The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. Nutr Metab Cardiovasc Dis. 2013;23(6):543–9.PubMedCrossRef Manning PJ, Sutherland WH, Williams SM, et al. The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. Nutr Metab Cardiovasc Dis. 2013;23(6):543–9.PubMedCrossRef
36.
Zurück zum Zitat Hoffman RM, Garewal HS. Alpha-tocopherol supplementation for men with existing coronary artery disease: a feasibility study. Prev Med. 1999;29(2):112–8.PubMedCrossRef Hoffman RM, Garewal HS. Alpha-tocopherol supplementation for men with existing coronary artery disease: a feasibility study. Prev Med. 1999;29(2):112–8.PubMedCrossRef
37.
Zurück zum Zitat Wluka AE, Stuckey S, Brand C, et al. Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: a 2 year double blind randomized placebo controlled study. J rheumatol. 2002;29(12):2585–91.PubMed Wluka AE, Stuckey S, Brand C, et al. Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: a 2 year double blind randomized placebo controlled study. J rheumatol. 2002;29(12):2585–91.PubMed
38.
Zurück zum Zitat Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362(18):1675–85.PubMedCentralPubMedCrossRef Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362(18):1675–85.PubMedCentralPubMedCrossRef
39.
Zurück zum Zitat de Waart FG, Kok FJ, Smilde TJ, et al. Effect of glutathione S-transferase M1 genotype on progression of atherosclerosis in lifelong male smokers. Atherosclerosis. 2001;158(1):227–31.PubMedCrossRef de Waart FG, Kok FJ, Smilde TJ, et al. Effect of glutathione S-transferase M1 genotype on progression of atherosclerosis in lifelong male smokers. Atherosclerosis. 2001;158(1):227–31.PubMedCrossRef
40.
Zurück zum Zitat Hodis HN, Mack WJ, LaBree L, et al. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). Circulation. 2002;106(12):1453–9.PubMedCrossRef Hodis HN, Mack WJ, LaBree L, et al. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). Circulation. 2002;106(12):1453–9.PubMedCrossRef
41.
Zurück zum Zitat Magliano D, McNeil J, Branley P, et al. The Melbourne Atherosclerosis Vitamin E Trial (MAVET): a study of high dose vitamin E in smokers. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology. 2006;13(3):341–7. Magliano D, McNeil J, Branley P, et al. The Melbourne Atherosclerosis Vitamin E Trial (MAVET): a study of high dose vitamin E in smokers. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology. 2006;13(3):341–7.
42.
Zurück zum Zitat Salonen JT, Nyyssonen K, Salonen R, et al. Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Intern Med. 2000;248(5):377–86.PubMedCrossRef Salonen JT, Nyyssonen K, Salonen R, et al. Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis. J Intern Med. 2000;248(5):377–86.PubMedCrossRef
43.
Zurück zum Zitat Graat JM, Schouten EG, Kok FJ. Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial. JAMA : J Am Med Assoc. 2002;288(6):715–21.CrossRef Graat JM, Schouten EG, Kok FJ. Effect of daily vitamin E and multivitamin-mineral supplementation on acute respiratory tract infections in elderly persons: a randomized controlled trial. JAMA : J Am Med Assoc. 2002;288(6):715–21.CrossRef
44.
Zurück zum Zitat McNeil JJ, Robman L, Tikellis G, et al. Vitamin E supplementation and cataract: randomized controlled trial. Ophthalmology. 2004;111(1):75–84.PubMedCrossRef McNeil JJ, Robman L, Tikellis G, et al. Vitamin E supplementation and cataract: randomized controlled trial. Ophthalmology. 2004;111(1):75–84.PubMedCrossRef
45.
Zurück zum Zitat Milman U, Blum S, Shapira C, et al. Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2–2 genotype: a prospective double-blinded clinical trial. Arterioscler Thromb Vasc Biol. 2008;28(2):341–7.PubMedCrossRef Milman U, Blum S, Shapira C, et al. Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2–2 genotype: a prospective double-blinded clinical trial. Arterioscler Thromb Vasc Biol. 2008;28(2):341–7.PubMedCrossRef
46.
Zurück zum Zitat Cook NR, Albert CM, Gaziano JM, et al. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women’s Antioxidant Cardiovascular Study. Arch Intern Med. 2007;167(15):1610–8.PubMedCentralPubMedCrossRef Cook NR, Albert CM, Gaziano JM, et al. A randomized factorial trial of vitamins C and E and beta carotene in the secondary prevention of cardiovascular events in women: results from the Women’s Antioxidant Cardiovascular Study. Arch Intern Med. 2007;167(15):1610–8.PubMedCentralPubMedCrossRef
47.
Zurück zum Zitat Lonn E, Bosch J, Yusuf S, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA : J Am Med Assoc. 2005;293(11):1338–47.CrossRef Lonn E, Bosch J, Yusuf S, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA : J Am Med Assoc. 2005;293(11):1338–47.CrossRef
48.
Zurück zum Zitat Gaziano JM, Glynn RJ, Christen WG, et al. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians’ Health Study II randomized controlled trial. JAMA : J Am Med Assoc. 2009;301(1):52–62.CrossRef Gaziano JM, Glynn RJ, Christen WG, et al. Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians’ Health Study II randomized controlled trial. JAMA : J Am Med Assoc. 2009;301(1):52–62.CrossRef
49.
Zurück zum Zitat Virtamo J, Pietinen P, Huttunen JK, et al. Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. JAMA : J Am Med Assoc. 2003;290(4):476–85.CrossRef Virtamo J, Pietinen P, Huttunen JK, et al. Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. JAMA : J Am Med Assoc. 2003;290(4):476–85.CrossRef
50.
Zurück zum Zitat Lippman SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA : J Am Med Assoc. 2009;301(1):39–51.CrossRef Lippman SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA : J Am Med Assoc. 2009;301(1):39–51.CrossRef
51.
Zurück zum Zitat Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women’s Health Study: a randomized controlled trial. JAMA : J Am Med Assoc. 2005;294(1):56–65.CrossRef Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women’s Health Study: a randomized controlled trial. JAMA : J Am Med Assoc. 2005;294(1):56–65.CrossRef
52.
Zurück zum Zitat Fortmann SP, Burda BU, Senger CA, et al. Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force. Annals of internal medicine 2013 Fortmann SP, Burda BU, Senger CA, et al. Vitamin and Mineral Supplements in the Primary Prevention of Cardiovascular Disease and Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force. Annals of internal medicine 2013
53.
Zurück zum Zitat Abner EL, Schmitt FA, Mendiondo MS, et al. Vitamin E and all-cause mortality: a meta-analysis. Current aging sci. 2011;4(2):158–70.CrossRef Abner EL, Schmitt FA, Mendiondo MS, et al. Vitamin E and all-cause mortality: a meta-analysis. Current aging sci. 2011;4(2):158–70.CrossRef
54.
Zurück zum Zitat Shekelle PG, Morton SC, Jungvig LK, et al. Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease. J Gen Intern Med. 2004;19(4):380–9.PubMedCentralPubMedCrossRef Shekelle PG, Morton SC, Jungvig LK, et al. Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease. J Gen Intern Med. 2004;19(4):380–9.PubMedCentralPubMedCrossRef
55.
Zurück zum Zitat Albanes D. Antioxidant supplements and mortality. JAMA : J Am Med Assoc. 2007;298(4):400. author reply 02–3.CrossRef Albanes D. Antioxidant supplements and mortality. JAMA : J Am Med Assoc. 2007;298(4):400. author reply 02–3.CrossRef
56.
Zurück zum Zitat Willcox BJ, Curb JD, Rodriguez BL. Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies. Am J Cardiol. 2008;101(10A):75D–86D.PubMedCrossRef Willcox BJ, Curb JD, Rodriguez BL. Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies. Am J Cardiol. 2008;101(10A):75D–86D.PubMedCrossRef
57.
Zurück zum Zitat Cordero Z, Drogan D, Weikert C, et al. Vitamin E and risk of cardiovascular diseases: a review of epidemiologic and clinical trial studies. Crit Rev Food Sci Nutr. 2010;50(5):420–40.PubMedCrossRef Cordero Z, Drogan D, Weikert C, et al. Vitamin E and risk of cardiovascular diseases: a review of epidemiologic and clinical trial studies. Crit Rev Food Sci Nutr. 2010;50(5):420–40.PubMedCrossRef
59.
Zurück zum Zitat Li H, Horke S, Forstermann U. Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis. 2014;237(1):208–19.PubMedCrossRef Li H, Horke S, Forstermann U. Vascular oxidative stress, nitric oxide and atherosclerosis. Atherosclerosis. 2014;237(1):208–19.PubMedCrossRef
Metadaten
Titel
Vitamin E Supplementation and Mortality in Healthy People: A Meta-Analysis of Randomised Controlled Trials
verfasst von
Andrea J. Curtis
Michael Bullen
Loretta Piccenna
John J. McNeil
Publikationsdatum
01.12.2014
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe 6/2014
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-014-6560-7

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