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Graefe's Archive for Clinical and Experimental Ophthalmology

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19.08.2020 | Retinal Disorders

Vitreous levels of vascular endothelial growth factor, stromal cell–derived factor-1α, and angiopoietin-like protein 2 in patients with active proliferative diabetic retinopathy

verfasst von: Ali Keles, Kenan Sonmez, Yasemin Ozdamar Erol, Sema Nur Ayyıldız, Elmas Ogus

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 1/2021

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Abstract

Purpose

To determine the vitreous levels of vascular endothelial growth factor (VEGF), stromal cell–derived factor-1α (SDF-1α) and angiopoietin-like protein 2 (ANGPTL2) in patients with active proliferative diabetic retinopathy (PDR), and to ascertain their contribution on different clinical presentation of active PDR.

Methods

This case–control study included 31 eyes with active PDR and 10 eyes with idiopathic macular hole (MH) (control group). Eyes with active PDR were divided into three subgroups: vitreous hemorrhage (VH), tractional retinal detachment (TRD) caused by active fibrovascular membrane (FVM), and coexistence of VH and TRD with FVM. Vitreous samples obtained during vitrectomy were analyzed for concentrations of VEGF, SDF-1α, and ANGPTL2.

Results

Vitreous level of VEGF (2021 (168–6550) pg/ml vs 110.1 (74.5–236) pg/ml), SDF-1α (517 (194–1044) pg/ml vs 388 (320–535) pg/ml), and ANGPTL2 (725 (131–1590) ng/ml vs 196 (75.9–437) ng/ml) were significantly higher in eyes with active PDR than in control group (p < 0.001, p = 0.002, and p < 0.001, respectively). The concentrations of these meaditors in each active PDR subgroups were also significantly higher than control group (p < 0.05). The vitreous level of ANGPTL2 was significantly higher in eyes with TRD caused by FVM (1033 ± 401 ng/ml) than in eyes with VH (561 ± 237 ng/ml; p = 0.008).

Conclusion

High levels of SDF-1α, ANGPTL2 and particularly VEGF seem to be associated with PDR. Since the vitreous levels of ANGPTL2 tend to be higher in eyes with active fibrovascular tractional detachment, vitreous levels of this chemokine seem to be affected by the clinical presentation of vascularly active PDR eyes.

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Titel: Vitreous levels of vascular endothelial growth factor, stromal cell–derived factor-1α, and angiopoietin-like protein 2 in patients with active proliferative diabetic retinopathy
verfasst von: Ali Keles
Kenan Sonmez
Yasemin Ozdamar Erol
Sema Nur Ayyıldız
Elmas Ogus
Publikationsdatum: 19.08.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 1/2021
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-020-04889-0

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Vitreous levels of vascular endothelial growth factor, stromal cell–derived factor-1α, and angiopoietin-like protein 2 in patients with active proliferative diabetic retinopathy

Abstract

Purpose

Methods

Results

Conclusion

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