Skip to main content
Erschienen in: Der Anaesthesist 3/2018

01.03.2018 | Muskelrelaxanzien | Leitthema

Vollrelaxation

Nutzen und Risiken

verfasst von: Dr. C. Unterbuchner, DESA, M. Blobner

Erschienen in: Die Anaesthesiologie | Ausgabe 3/2018

Einloggen, um Zugang zu erhalten

Zusammenfassung

Vollrelaxation (TOF-Count = 0) kann Intubationsbedingungen und laryngeale Operationsbedingungen verbessern. Sowohl bei nichtlaparoskopischer als auch bei laparoskopischer Chirurgie optimiert die Vollrelaxation die Operationsbedingungen statistisch signifikant. Die klinische Relevanz ist unklar. Die tiefe neuromuskuläre Blockade verbessert die laparoskopischen Operationsbedingungen bei der Verwendung niedriger intraabdomineller Drücke nur marginal. Bei Laparoskopien zeigen niedrige gegenüber höheren intraabdominellen Drücken keine Outcome-relevanten Vorteile, verschlechtern aber die Operationsbedingungen. Postoperative, residuelle Curarisierung kann durch quantitatives Monitoring und pharmakologische Reversierung/Antagonisierung vermieden werden.
Literatur
2.
Zurück zum Zitat Amaki Y, Haziri H, Sugimoto N et al (1990) The degree of muscle relaxation requested by the surgens during upper abdominal surgery. J Anesth 4:249–252CrossRefPubMed Amaki Y, Haziri H, Sugimoto N et al (1990) The degree of muscle relaxation requested by the surgens during upper abdominal surgery. J Anesth 4:249–252CrossRefPubMed
3.
Zurück zum Zitat Barrio J, Errando CL, San Miguel G et al (2016) Effect of depth of neuromuscular blockade on the abdominal space during pneumoperitoneum establishment in laparoscopic surgery. J Clin Anesth 34:197–203CrossRefPubMed Barrio J, Errando CL, San Miguel G et al (2016) Effect of depth of neuromuscular blockade on the abdominal space during pneumoperitoneum establishment in laparoscopic surgery. J Clin Anesth 34:197–203CrossRefPubMed
4.
Zurück zum Zitat Bisgaard T, Kehlet H, Rosenberg J (2001) Pain and convalescence after laparoscopic cholecystectomy. Eur J Surg 167:84–96CrossRefPubMed Bisgaard T, Kehlet H, Rosenberg J (2001) Pain and convalescence after laparoscopic cholecystectomy. Eur J Surg 167:84–96CrossRefPubMed
5.
Zurück zum Zitat Blobner M, Eriksson LI, Scholz J et al (2010) Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial. Eur J Anaesthesiol 27:874–881CrossRefPubMed Blobner M, Eriksson LI, Scholz J et al (2010) Reversal of rocuronium-induced neuromuscular blockade with sugammadex compared with neostigmine during sevoflurane anaesthesia: results of a randomised, controlled trial. Eur J Anaesthesiol 27:874–881CrossRefPubMed
6.
Zurück zum Zitat Blobner M, Frick CG, Stauble RB et al (2015) Neuromuscular blockade improves surgical conditions (NISCO). Surg Endosc 29:627–636CrossRefPubMed Blobner M, Frick CG, Stauble RB et al (2015) Neuromuscular blockade improves surgical conditions (NISCO). Surg Endosc 29:627–636CrossRefPubMed
7.
Zurück zum Zitat Bruintjes MH, van Helden EV, Braat AE et al (2017) Deep neuromuscular block to optimize surgical space conditions during laparoscopic surgery: a systematic review and meta-analysis. Br J Anaesth 118:834–842CrossRefPubMed Bruintjes MH, van Helden EV, Braat AE et al (2017) Deep neuromuscular block to optimize surgical space conditions during laparoscopic surgery: a systematic review and meta-analysis. Br J Anaesth 118:834–842CrossRefPubMed
8.
Zurück zum Zitat Brull SJ, Kopman AF (2017) Current status of neuromuscular reversal and monitoring: challenges and opportunities. Anesthesiology 126:173–190CrossRefPubMed Brull SJ, Kopman AF (2017) Current status of neuromuscular reversal and monitoring: challenges and opportunities. Anesthesiology 126:173–190CrossRefPubMed
9.
Zurück zum Zitat Brull SJ, Murphy GS (2010) Residual neuromuscular block: lessons unlearned. Part II: methods to reduce the risk of residual weakness. Anesth Analg 111:129–140CrossRefPubMed Brull SJ, Murphy GS (2010) Residual neuromuscular block: lessons unlearned. Part II: methods to reduce the risk of residual weakness. Anesth Analg 111:129–140CrossRefPubMed
10.
Zurück zum Zitat Capron F, Alla F, Hottier C et al (2004) Can acceleromyography detect low levels of residual paralysis? A probability approach to detect a mechanomyographic train-of-four ratio of 0.9. Anesthesiology 100:1119–1124CrossRefPubMed Capron F, Alla F, Hottier C et al (2004) Can acceleromyography detect low levels of residual paralysis? A probability approach to detect a mechanomyographic train-of-four ratio of 0.9. Anesthesiology 100:1119–1124CrossRefPubMed
11.
Zurück zum Zitat Casanova J, Pineiro P, De La Gala F et al (2017) Deep versus moderate neuromuscular block during one-lung ventilation in lung resection surgery. Rev Bras Anestesiol 67:288–293CrossRefPubMed Casanova J, Pineiro P, De La Gala F et al (2017) Deep versus moderate neuromuscular block during one-lung ventilation in lung resection surgery. Rev Bras Anestesiol 67:288–293CrossRefPubMed
12.
Zurück zum Zitat Cepeda MS, Africano JM, Polo R et al (2003) What decline in pain intensity is meaningful to patients with acute pain? Pain 105:151–157CrossRefPubMed Cepeda MS, Africano JM, Polo R et al (2003) What decline in pain intensity is meaningful to patients with acute pain? Pain 105:151–157CrossRefPubMed
13.
Zurück zum Zitat Chaudhari LS, Shetty AN, Buddhi M et al (1999) A comparison of continuous infusion of vecuronium and atracurium in midline and paramedian laparotomies. J Postgrad Med 45:5–9PubMed Chaudhari LS, Shetty AN, Buddhi M et al (1999) A comparison of continuous infusion of vecuronium and atracurium in midline and paramedian laparotomies. J Postgrad Med 45:5–9PubMed
14.
Zurück zum Zitat Chiu AW, Azadzoi KM, Hatzichristou DG et al (1994) Effects of intra-abdominal pressure on renal tissue perfusion during laparoscopy. J Endourol 8:99–103CrossRefPubMed Chiu AW, Azadzoi KM, Hatzichristou DG et al (1994) Effects of intra-abdominal pressure on renal tissue perfusion during laparoscopy. J Endourol 8:99–103CrossRefPubMed
15.
Zurück zum Zitat Dhonneur G, Kirov K, Motamed C et al (2007) Post-tetanic count at adductor pollicis is a better indicator of early diaphragmatic recovery than train-of-four count at corrugator supercilii. Br J Anaesth 99:376–379CrossRefPubMed Dhonneur G, Kirov K, Motamed C et al (2007) Post-tetanic count at adductor pollicis is a better indicator of early diaphragmatic recovery than train-of-four count at corrugator supercilii. Br J Anaesth 99:376–379CrossRefPubMed
16.
Zurück zum Zitat Donatsky AM, Bjerrum F, Gogenur I (2013) Surgical techniques to minimize shoulder pain after laparoscopic cholecystectomy. A systematic review. Surg Endosc 27:2275–2282CrossRefPubMed Donatsky AM, Bjerrum F, Gogenur I (2013) Surgical techniques to minimize shoulder pain after laparoscopic cholecystectomy. A systematic review. Surg Endosc 27:2275–2282CrossRefPubMed
17.
Zurück zum Zitat Dubois PE, Putz L, Jamart J et al (2014) Deep neuromuscular block improves surgical conditions during laparoscopic hysterectomy: a randomised controlled trial. Eur J Anaesthesiol 31:430–436CrossRefPubMed Dubois PE, Putz L, Jamart J et al (2014) Deep neuromuscular block improves surgical conditions during laparoscopic hysterectomy: a randomised controlled trial. Eur J Anaesthesiol 31:430–436CrossRefPubMed
18.
Zurück zum Zitat Duvaldestin P, Kuizenga K, Saldien V et al (2010) A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia. Anesth Analg 110:74–82CrossRefPubMed Duvaldestin P, Kuizenga K, Saldien V et al (2010) A randomized, dose-response study of sugammadex given for the reversal of deep rocuronium- or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia. Anesth Analg 110:74–82CrossRefPubMed
19.
Zurück zum Zitat El-Boghdadly K, Bailey CR, Wiles MD (2016) Postoperative sore throat: a systematic review. Anaesthesia 71:706–717CrossRefPubMed El-Boghdadly K, Bailey CR, Wiles MD (2016) Postoperative sore throat: a systematic review. Anaesthesia 71:706–717CrossRefPubMed
20.
Zurück zum Zitat El-Tahan MR, Regal M (2015) Target-controlled infusion of remifentanil without muscle relaxants allows acceptable surgical conditions during thoracotomy performed under sevoflurane anesthesia. J Cardiothorac Vasc Anesth 29:1557–1566CrossRefPubMed El-Tahan MR, Regal M (2015) Target-controlled infusion of remifentanil without muscle relaxants allows acceptable surgical conditions during thoracotomy performed under sevoflurane anesthesia. J Cardiothorac Vasc Anesth 29:1557–1566CrossRefPubMed
21.
Zurück zum Zitat Eleveld DJ, Kuizenga K, Proost JH et al (2007) A temporary decrease in twitch response during reversal of rocuronium-induced muscle relaxation with a small dose of sugammadex. Anesth Analg 104:582–584CrossRefPubMed Eleveld DJ, Kuizenga K, Proost JH et al (2007) A temporary decrease in twitch response during reversal of rocuronium-induced muscle relaxation with a small dose of sugammadex. Anesth Analg 104:582–584CrossRefPubMed
22.
Zurück zum Zitat Farrar JT (2010) Cut-points for the measurement of pain: the choice depends on what you want to study. Pain 149:163–164CrossRefPubMed Farrar JT (2010) Cut-points for the measurement of pain: the choice depends on what you want to study. Pain 149:163–164CrossRefPubMed
23.
Zurück zum Zitat Fernando PU, Viby-Mogensen J, Bonsu AK et al (1987) Relationship between posttetanic count and response to carinal stimulation during vecuronium-induced neuromuscular blockade. Acta Anaesthesiol Scand 31:593–596CrossRefPubMed Fernando PU, Viby-Mogensen J, Bonsu AK et al (1987) Relationship between posttetanic count and response to carinal stimulation during vecuronium-induced neuromuscular blockade. Acta Anaesthesiol Scand 31:593–596CrossRefPubMed
24.
Zurück zum Zitat Fuchs-Buder T, Claudius C, Skovgaard LT et al (2007) Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision. Acta Anaesthesiol Scand 51:789–808CrossRefPubMed Fuchs-Buder T, Claudius C, Skovgaard LT et al (2007) Good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents II: the Stockholm revision. Acta Anaesthesiol Scand 51:789–808CrossRefPubMed
25.
Zurück zum Zitat Fuchs-Buder T, Meistelman C, Alla F et al (2010) Antagonism of low degrees of atracurium-induced neuromuscular blockade: dose-effect relationship for neostigmine. Anesthesiology 112:34–40CrossRefPubMed Fuchs-Buder T, Meistelman C, Alla F et al (2010) Antagonism of low degrees of atracurium-induced neuromuscular blockade: dose-effect relationship for neostigmine. Anesthesiology 112:34–40CrossRefPubMed
26.
Zurück zum Zitat Fuchs-Buder T, Schreiber JU (2011) Muscle relaxants are obligatory for pediatric intubation: pro. Anaesthesist 60:474–475CrossRefPubMed Fuchs-Buder T, Schreiber JU (2011) Muscle relaxants are obligatory for pediatric intubation: pro. Anaesthesist 60:474–475CrossRefPubMed
27.
Zurück zum Zitat Fujita Y, Moriyama S, Aoki S et al (2015) Estimation of the success rate of anesthetic management for thymectomy in patients with myasthenia gravis treated without muscle relaxants: a retrospective observational cohort study. J Anesth 29:794–797CrossRefPubMed Fujita Y, Moriyama S, Aoki S et al (2015) Estimation of the success rate of anesthetic management for thymectomy in patients with myasthenia gravis treated without muscle relaxants: a retrospective observational cohort study. J Anesth 29:794–797CrossRefPubMed
29.
30.
Zurück zum Zitat Grosse-Sundrup M, Henneman JP, Sandberg WS et al (2012) Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study. BMJ 345:e6329CrossRefPubMedPubMedCentral Grosse-Sundrup M, Henneman JP, Sandberg WS et al (2012) Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study. BMJ 345:e6329CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Gueret G, Rossignol B, Kiss G et al (2004) Is muscle relaxant necessary for cardiac surgery? Anesth Analg 99:1330–1333CrossRefPubMed Gueret G, Rossignol B, Kiss G et al (2004) Is muscle relaxant necessary for cardiac surgery? Anesth Analg 99:1330–1333CrossRefPubMed
34.
Zurück zum Zitat Johr M (2011) Endotracheal intubation in pediatric patients: with or without neuromuscular blocking agents? Anaesthesist 60:406CrossRefPubMed Johr M (2011) Endotracheal intubation in pediatric patients: with or without neuromuscular blocking agents? Anaesthesist 60:406CrossRefPubMed
35.
Zurück zum Zitat Jones RK, Caldwell JE, Brull SJ et al (2008) Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine. Anesthesiology 109:816–824CrossRefPubMed Jones RK, Caldwell JE, Brull SJ et al (2008) Reversal of profound rocuronium-induced blockade with sugammadex: a randomized comparison with neostigmine. Anesthesiology 109:816–824CrossRefPubMed
36.
Zurück zum Zitat Julien-Marsollier F, Michelet D, Bellon M et al (2017) Muscle relaxation for tracheal intubation during paediatric anaesthesia: a meta-analysis and trial sequential analysis. Eur J Anaesthesiol 34:550–561CrossRefPubMed Julien-Marsollier F, Michelet D, Bellon M et al (2017) Muscle relaxation for tracheal intubation during paediatric anaesthesia: a meta-analysis and trial sequential analysis. Eur J Anaesthesiol 34:550–561CrossRefPubMed
37.
Zurück zum Zitat Kaufhold N, Schaller SJ, Stauble CG et al (2016) Sugammadex and neostigmine dose-finding study for reversal of residual neuromuscular block at a train-of-four ratio of 0.2 (SUNDRO20)dagger. Br J Anaesth 116:233–240CrossRefPubMed Kaufhold N, Schaller SJ, Stauble CG et al (2016) Sugammadex and neostigmine dose-finding study for reversal of residual neuromuscular block at a train-of-four ratio of 0.2 (SUNDRO20)dagger. Br J Anaesth 116:233–240CrossRefPubMed
39.
Zurück zum Zitat Kim HJ, Lee K, Park WK et al (2015) Deep neuromuscular block improves the surgical conditions for laryngeal microsurgery. Br J Anaesth 115:867–872CrossRefPubMed Kim HJ, Lee K, Park WK et al (2015) Deep neuromuscular block improves the surgical conditions for laryngeal microsurgery. Br J Anaesth 115:867–872CrossRefPubMed
40.
Zurück zum Zitat Kim MH, Lee KY, Lee KY et al (2016) Maintaining optimal surgical conditions with low Insufflation pressures is possible with deep neuromuscular blockade during laparoscopic colorectal surgery: a prospective, randomized, double-blind, parallel-group clinical trial. Medicine (Baltimore) 95:e2920CrossRef Kim MH, Lee KY, Lee KY et al (2016) Maintaining optimal surgical conditions with low Insufflation pressures is possible with deep neuromuscular blockade during laparoscopic colorectal surgery: a prospective, randomized, double-blind, parallel-group clinical trial. Medicine (Baltimore) 95:e2920CrossRef
41.
Zurück zum Zitat King M, Sujirattanawimol N, Danielson DR et al (2000) Requirements for muscle relaxants during radical retropubic prostatectomy. Anesthesiology 93:1392–1397CrossRefPubMed King M, Sujirattanawimol N, Danielson DR et al (2000) Requirements for muscle relaxants during radical retropubic prostatectomy. Anesthesiology 93:1392–1397CrossRefPubMed
42.
Zurück zum Zitat Kirov K, Motamed C, Ndoko SK et al (2007) TOF count at corrugator supercilii reflects abdominal muscles relaxation better than at adductor pollicis. Br J Anaesth 98:611–614CrossRefPubMed Kirov K, Motamed C, Ndoko SK et al (2007) TOF count at corrugator supercilii reflects abdominal muscles relaxation better than at adductor pollicis. Br J Anaesth 98:611–614CrossRefPubMed
43.
Zurück zum Zitat Koo BW, Oh AY, Seo KS et al (2016) Randomized clinical trial of moderate versus deep neuromuscular block for low-pressure pneumoperitoneum during laparoscopic cholecystectomy. World J Surg 40:2898–2903CrossRefPubMed Koo BW, Oh AY, Seo KS et al (2016) Randomized clinical trial of moderate versus deep neuromuscular block for low-pressure pneumoperitoneum during laparoscopic cholecystectomy. World J Surg 40:2898–2903CrossRefPubMed
44.
Zurück zum Zitat Kopman AF, Naguib M (2015) Laparoscopic surgery and muscle relaxants: is deep block helpful? Anesth Analg 120:51–58CrossRefPubMed Kopman AF, Naguib M (2015) Laparoscopic surgery and muscle relaxants: is deep block helpful? Anesth Analg 120:51–58CrossRefPubMed
45.
Zurück zum Zitat Kopman AF, Naguib M (2016) Is deep neuromuscular block beneficial in laparoscopic surgery? No, probably not. Acta Anaesthesiol Scand 60:717–722CrossRefPubMed Kopman AF, Naguib M (2016) Is deep neuromuscular block beneficial in laparoscopic surgery? No, probably not. Acta Anaesthesiol Scand 60:717–722CrossRefPubMed
46.
Zurück zum Zitat Kotake Y, Ochiai R, Suzuki T et al (2013) Reversal with sugammadex in the absence of monitoring did not preclude residual neuromuscular block. Anesth Analg 117:345–351CrossRefPubMed Kotake Y, Ochiai R, Suzuki T et al (2013) Reversal with sugammadex in the absence of monitoring did not preclude residual neuromuscular block. Anesth Analg 117:345–351CrossRefPubMed
48.
Zurück zum Zitat Li YL, Liu YL, Xu CM et al (2014) The effects of neuromuscular blockade on operating conditions during general anesthesia for spinal surgery. J Neurosurg Anesthesiol 26:45–49CrossRefPubMed Li YL, Liu YL, Xu CM et al (2014) The effects of neuromuscular blockade on operating conditions during general anesthesia for spinal surgery. J Neurosurg Anesthesiol 26:45–49CrossRefPubMed
51.
Zurück zum Zitat Maddineni VR, Mirakhur RK, McCoy EP (1994) Recovery of mivacurium block with or without anticholinesterases following administration by continuous infusion. Anaesthesia 49:946–948CrossRefPubMed Maddineni VR, Mirakhur RK, McCoy EP (1994) Recovery of mivacurium block with or without anticholinesterases following administration by continuous infusion. Anaesthesia 49:946–948CrossRefPubMed
52.
Zurück zum Zitat Madsen MV, Gatke MR, Springborg HH et al (2015) Optimising abdominal space with deep neuromuscular blockade in gynaecologic laparoscopy – a randomised, blinded crossover study. Acta Anaesthesiol Scand 59:441–447CrossRefPubMed Madsen MV, Gatke MR, Springborg HH et al (2015) Optimising abdominal space with deep neuromuscular blockade in gynaecologic laparoscopy – a randomised, blinded crossover study. Acta Anaesthesiol Scand 59:441–447CrossRefPubMed
53.
Zurück zum Zitat Madsen MV, Istre O, Springborg HH et al (2017) Deep neuromuscular blockade and low insufflation pressure during laparoscopic hysterectomy. Dan Med J 64(5):A5364PubMed Madsen MV, Istre O, Springborg HH et al (2017) Deep neuromuscular blockade and low insufflation pressure during laparoscopic hysterectomy. Dan Med J 64(5):A5364PubMed
54.
Zurück zum Zitat Madsen MV, Istre O, Staehr-Rye AK et al (2016) Postoperative shoulder pain after laparoscopic hysterectomy with deep neuromuscular blockade and low-pressure pneumoperitoneum: a randomised controlled trial. Eur J Anaesthesiol 33:341–347CrossRefPubMed Madsen MV, Istre O, Staehr-Rye AK et al (2016) Postoperative shoulder pain after laparoscopic hysterectomy with deep neuromuscular blockade and low-pressure pneumoperitoneum: a randomised controlled trial. Eur J Anaesthesiol 33:341–347CrossRefPubMed
55.
Zurück zum Zitat Madsen MV, Scheppan S, Mork E et al (2017) Influence of deep neuromuscular block on the surgeons assessment of surgical conditions during laparotomy: a randomized controlled double blinded trial with rocuronium and sugammadex. Br J Anaesth 119:435–442CrossRefPubMed Madsen MV, Scheppan S, Mork E et al (2017) Influence of deep neuromuscular block on the surgeons assessment of surgical conditions during laparotomy: a randomized controlled double blinded trial with rocuronium and sugammadex. Br J Anaesth 119:435–442CrossRefPubMed
56.
Zurück zum Zitat Madsen MV, Staehr-Rye AK, Claudius C et al (2016) Is deep neuromuscular blockade beneficial in laparoscopic surgery? Yes, probably. Acta Anaesthesiol Scand 60:710–716CrossRefPubMed Madsen MV, Staehr-Rye AK, Claudius C et al (2016) Is deep neuromuscular blockade beneficial in laparoscopic surgery? Yes, probably. Acta Anaesthesiol Scand 60:710–716CrossRefPubMed
57.
Zurück zum Zitat Madsen MV, Staehr-Rye AK, Gatke MR et al (2015) Neuromuscular blockade for optimising surgical conditions during abdominal and gynaecological surgery: a systematic review. Acta Anaesthesiol Scand 59:1–16CrossRefPubMed Madsen MV, Staehr-Rye AK, Gatke MR et al (2015) Neuromuscular blockade for optimising surgical conditions during abdominal and gynaecological surgery: a systematic review. Acta Anaesthesiol Scand 59:1–16CrossRefPubMed
58.
Zurück zum Zitat Magorian TT, Lynam DP, Caldwell JE et al (1990) Can early administration of neostigmine, in single or repeated doses, alter the course of neuromuscular recovery from a vecuronium-induced neuromuscular blockade? Anesthesiology 73:410–414CrossRefPubMed Magorian TT, Lynam DP, Caldwell JE et al (1990) Can early administration of neostigmine, in single or repeated doses, alter the course of neuromuscular recovery from a vecuronium-induced neuromuscular blockade? Anesthesiology 73:410–414CrossRefPubMed
59.
Zurück zum Zitat Martini CH, Boon M, Bevers RF et al (2014) Evaluation of surgical conditions during laparoscopic surgery in patients with moderate vs deep neuromuscular block. Br J Anaesth 112:498–505CrossRefPubMed Martini CH, Boon M, Bevers RF et al (2014) Evaluation of surgical conditions during laparoscopic surgery in patients with moderate vs deep neuromuscular block. Br J Anaesth 112:498–505CrossRefPubMed
60.
Zurück zum Zitat Maybauer DM, Geldner G, Blobner M et al (2007) Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuronium. Anaesthesia 62:12–17CrossRefPubMed Maybauer DM, Geldner G, Blobner M et al (2007) Incidence and duration of residual paralysis at the end of surgery after multiple administrations of cisatracurium and rocuronium. Anaesthesia 62:12–17CrossRefPubMed
61.
Zurück zum Zitat McLean DJ, Diaz-Gil D, Farhan HN et al (2015) Dose-dependent association between intermediate-acting neuromuscular-blocking agents and postoperative respiratory complications. Anesthesiology 122:1201–1213CrossRefPubMed McLean DJ, Diaz-Gil D, Farhan HN et al (2015) Dose-dependent association between intermediate-acting neuromuscular-blocking agents and postoperative respiratory complications. Anesthesiology 122:1201–1213CrossRefPubMed
62.
Zurück zum Zitat Mencke T, Echternach M, Kleinschmidt S et al (2003) Laryngeal morbidity and quality of tracheal intubation: a randomized controlled trial. Anesthesiology 98:1049–1056CrossRefPubMed Mencke T, Echternach M, Kleinschmidt S et al (2003) Laryngeal morbidity and quality of tracheal intubation: a randomized controlled trial. Anesthesiology 98:1049–1056CrossRefPubMed
63.
Zurück zum Zitat Mouton WG, Bessell JR, Otten KT et al (1999) Pain after laparoscopy. Surg Endosc 13:445–448CrossRefPubMed Mouton WG, Bessell JR, Otten KT et al (1999) Pain after laparoscopy. Surg Endosc 13:445–448CrossRefPubMed
64.
Zurück zum Zitat Mulier JP, Dillemans B, Van Cauwenberge S (2010) Impact of the patient’s body position on the intraabdominal workspace during laparoscopic surgery. Surg Endosc 24:1398–1402CrossRefPubMedPubMedCentral Mulier JP, Dillemans B, Van Cauwenberge S (2010) Impact of the patient’s body position on the intraabdominal workspace during laparoscopic surgery. Surg Endosc 24:1398–1402CrossRefPubMedPubMedCentral
65.
Zurück zum Zitat Murphy GS, Szokol JW, Marymont JH et al (2008) Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit. Anesth Analg 107:130–137CrossRefPubMed Murphy GS, Szokol JW, Marymont JH et al (2008) Residual neuromuscular blockade and critical respiratory events in the postanesthesia care unit. Anesth Analg 107:130–137CrossRefPubMed
66.
Zurück zum Zitat Nemes R, Fulesdi B, Pongracz A et al (2017) Impact of reversal strategies on the incidence of postoperative residual paralysis after rocuronium relaxation without neuromuscular monitoring: a partially randomised placebo controlled trial. Eur J Anaesthesiol 34:609–616CrossRefPubMed Nemes R, Fulesdi B, Pongracz A et al (2017) Impact of reversal strategies on the incidence of postoperative residual paralysis after rocuronium relaxation without neuromuscular monitoring: a partially randomised placebo controlled trial. Eur J Anaesthesiol 34:609–616CrossRefPubMed
67.
Zurück zum Zitat Nishio S, Takeda H, Yokoyama M (1999) Changes in urinary output during laparoscopic adrenalectomy. BJU Int 83:944–947CrossRefPubMed Nishio S, Takeda H, Yokoyama M (1999) Changes in urinary output during laparoscopic adrenalectomy. BJU Int 83:944–947CrossRefPubMed
68.
Zurück zum Zitat Ozdemir-van Brunschot DM, van Laarhoven KC, Scheffer GJ et al (2016) What is the evidence for the use of low-pressure pneumoperitoneum? A systematic review. Surg Endosc 30:2049–2065CrossRefPubMed Ozdemir-van Brunschot DM, van Laarhoven KC, Scheffer GJ et al (2016) What is the evidence for the use of low-pressure pneumoperitoneum? A systematic review. Surg Endosc 30:2049–2065CrossRefPubMed
71.
Zurück zum Zitat Paek CM, Yi JW, Lee BJ et al (2009) No supplemental muscle relaxants are required during propofol and remifentanil total intravenous anesthesia for laparoscopic pelvic surgery. J Laparoendosc Adv Surg Tech A 19:33–37CrossRefPubMed Paek CM, Yi JW, Lee BJ et al (2009) No supplemental muscle relaxants are required during propofol and remifentanil total intravenous anesthesia for laparoscopic pelvic surgery. J Laparoendosc Adv Surg Tech A 19:33–37CrossRefPubMed
72.
Zurück zum Zitat Paton F, Paulden M, Chambers D et al (2010) Sugammadex compared with neostigmine/glycopyrrolate for routine reversal of neuromuscular block: a systematic review and economic evaluation. Br J Anaesth 105:558–567CrossRefPubMedPubMedCentral Paton F, Paulden M, Chambers D et al (2010) Sugammadex compared with neostigmine/glycopyrrolate for routine reversal of neuromuscular block: a systematic review and economic evaluation. Br J Anaesth 105:558–567CrossRefPubMedPubMedCentral
73.
Zurück zum Zitat Plaud B, Debaene B, Donati F (2001) The corrugator supercilii, not the orbicularis oculi, reflects rocuronium neuromuscular blockade at the laryngeal adductor muscles. Anesthesiology 95:96–101CrossRefPubMed Plaud B, Debaene B, Donati F (2001) The corrugator supercilii, not the orbicularis oculi, reflects rocuronium neuromuscular blockade at the laryngeal adductor muscles. Anesthesiology 95:96–101CrossRefPubMed
74.
Zurück zum Zitat Pongracz A, Szatmari S, Nemes R et al (2013) Reversal of neuromuscular blockade with sugammadex at the reappearance of four twitches to train-of-four stimulation. Anesthesiology 119:36–42CrossRefPubMed Pongracz A, Szatmari S, Nemes R et al (2013) Reversal of neuromuscular blockade with sugammadex at the reappearance of four twitches to train-of-four stimulation. Anesthesiology 119:36–42CrossRefPubMed
75.
76.
Zurück zum Zitat Ripke F, Fink H, Blobner M (2014) Concepts for the avoidance of residual neuromuscular blockades after the administration of nondepolarizing muscle relaxants. Anasthesiol Intensivmed 55:564–576 Ripke F, Fink H, Blobner M (2014) Concepts for the avoidance of residual neuromuscular blockades after the administration of nondepolarizing muscle relaxants. Anasthesiol Intensivmed 55:564–576
77.
Zurück zum Zitat Rosenberg J, Herring WJ, Blobner M et al (2017) Deep neuromuscular blockade improves laparoscopic surgical conditions: a randomized, controlled study. Adv Ther 34:925–936CrossRefPubMed Rosenberg J, Herring WJ, Blobner M et al (2017) Deep neuromuscular blockade improves laparoscopic surgical conditions: a randomized, controlled study. Adv Ther 34:925–936CrossRefPubMed
78.
Zurück zum Zitat Schaller SJ, Fink H, Ulm K et al (2010) Sugammadex and neostigmine dose-finding study for reversal of shallow residual neuromuscular block. Anesthesiology 113:1054–1060CrossRefPubMed Schaller SJ, Fink H, Ulm K et al (2010) Sugammadex and neostigmine dose-finding study for reversal of shallow residual neuromuscular block. Anesthesiology 113:1054–1060CrossRefPubMed
79.
Zurück zum Zitat Schlaich N, Mertzlufft F, Soltesz S et al (2000) Remifentanil and propofol without muscle relaxants or with different doses of rocuronium for tracheal intubation in outpatient anaesthesia. Acta Anaesthesiol Scand 44:720–726CrossRefPubMed Schlaich N, Mertzlufft F, Soltesz S et al (2000) Remifentanil and propofol without muscle relaxants or with different doses of rocuronium for tracheal intubation in outpatient anaesthesia. Acta Anaesthesiol Scand 44:720–726CrossRefPubMed
80.
Zurück zum Zitat Staehr-Rye AK, Rasmussen LS, Rosenberg J et al (2014) Surgical space conditions during low-pressure laparoscopic cholecystectomy with deep versus moderate neuromuscular blockade: a randomized clinical study. Anesth Analg 119:1084–1092CrossRefPubMed Staehr-Rye AK, Rasmussen LS, Rosenberg J et al (2014) Surgical space conditions during low-pressure laparoscopic cholecystectomy with deep versus moderate neuromuscular blockade: a randomized clinical study. Anesth Analg 119:1084–1092CrossRefPubMed
81.
Zurück zum Zitat Tammisto T, Olkkola KT (1995) Dependence of the adequacy of muscle relaxation on the degree of neuromuscular block and depth of enflurane anesthesia during abdominal surgery. Anesth Analg 80:543–547PubMed Tammisto T, Olkkola KT (1995) Dependence of the adequacy of muscle relaxation on the degree of neuromuscular block and depth of enflurane anesthesia during abdominal surgery. Anesth Analg 80:543–547PubMed
82.
Zurück zum Zitat Todd MM, Hindman BJ, King BJ (2014) The implementation of quantitative electromyographic neuromuscular monitoring in an academic anesthesia department. Anesth Analg 119:323–331CrossRefPubMed Todd MM, Hindman BJ, King BJ (2014) The implementation of quantitative electromyographic neuromuscular monitoring in an academic anesthesia department. Anesth Analg 119:323–331CrossRefPubMed
83.
Zurück zum Zitat Toker A, Eroglu O, Ziyade S et al (2005) Comparison of early postoperative results of thymectomy: partial sternotomy vs. videothoracoscopy. Thorac Cardiovasc Surg 53:110–113CrossRefPubMed Toker A, Eroglu O, Ziyade S et al (2005) Comparison of early postoperative results of thymectomy: partial sternotomy vs. videothoracoscopy. Thorac Cardiovasc Surg 53:110–113CrossRefPubMed
84.
Zurück zum Zitat Torensma B, Martini CH, Boon M et al (2016) Deep neuromuscular block improves surgical conditions during bariatric surgery and reduces postoperative pain: a randomized double blind controlled trial. PLoS ONE 11:e167907CrossRefPubMedPubMedCentral Torensma B, Martini CH, Boon M et al (2016) Deep neuromuscular block improves surgical conditions during bariatric surgery and reduces postoperative pain: a randomized double blind controlled trial. PLoS ONE 11:e167907CrossRefPubMedPubMedCentral
85.
Zurück zum Zitat Unterbuchner C, Blobner M, Puhringer F et al (2017) Development of an algorithm using clinical tests to avoid post-operative residual neuromuscular block. BMC Anesthesiol 17:101CrossRefPubMedPubMedCentral Unterbuchner C, Blobner M, Puhringer F et al (2017) Development of an algorithm using clinical tests to avoid post-operative residual neuromuscular block. BMC Anesthesiol 17:101CrossRefPubMedPubMedCentral
86.
Zurück zum Zitat Unterbuchner C, Fink H, Blobner M (2010) The use of sugammadex in a patient with myasthenia gravis. Anaesthesia 65:302–305CrossRefPubMed Unterbuchner C, Fink H, Blobner M (2010) The use of sugammadex in a patient with myasthenia gravis. Anaesthesia 65:302–305CrossRefPubMed
87.
Zurück zum Zitat Unterbuchner C, Werkmann M (2017) Postoperative shoulder pain after laparoscopic hysterectomy with deep neuromuscular blockade and low-pressure pneumoperitoneum. Eur J Anaesthesiol 34:25–26CrossRefPubMed Unterbuchner C, Werkmann M (2017) Postoperative shoulder pain after laparoscopic hysterectomy with deep neuromuscular blockade and low-pressure pneumoperitoneum. Eur J Anaesthesiol 34:25–26CrossRefPubMed
88.
Zurück zum Zitat Viby-Mogensen J, Jensen NH, Engbaek J et al (1985) Tactile and visual evaluation of the response to train-of-four nerve stimulation. Anesthesiology 63:440–443CrossRefPubMed Viby-Mogensen J, Jensen NH, Engbaek J et al (1985) Tactile and visual evaluation of the response to train-of-four nerve stimulation. Anesthesiology 63:440–443CrossRefPubMed
89.
Zurück zum Zitat von Ungern-Sternberg BS (2011) Muscle relaxants are obligatory for pediatric intubation: con. Anaesthesist 60:476–478CrossRef von Ungern-Sternberg BS (2011) Muscle relaxants are obligatory for pediatric intubation: con. Anaesthesist 60:476–478CrossRef
90.
Zurück zum Zitat Warle MC, Berkers AW, Langenhuijsen JF et al (2013) Low-pressure pneumoperitoneum during laparoscopic donor nephrectomy to optimize live donors’ comfort. Clin Transplant 27:E478–483CrossRefPubMed Warle MC, Berkers AW, Langenhuijsen JF et al (2013) Low-pressure pneumoperitoneum during laparoscopic donor nephrectomy to optimize live donors’ comfort. Clin Transplant 27:E478–483CrossRefPubMed
91.
Zurück zum Zitat Weld KJ, Ames CD, Landman J et al (2005) Evaluation of intra-abdominal pressures and gas embolism during laparoscopic partial nephrectomy in a porcine model. J Urol 174:1457–1459CrossRefPubMed Weld KJ, Ames CD, Landman J et al (2005) Evaluation of intra-abdominal pressures and gas embolism during laparoscopic partial nephrectomy in a porcine model. J Urol 174:1457–1459CrossRefPubMed
92.
Zurück zum Zitat Werba A, Klezl M, Schramm W et al (1993) The level of neuromuscular block needed to suppress diaphragmatic movement during tracheal suction in patients with raised intracranial pressure: a study with vecuronium and atracurium. Anaesthesia 48:301–303CrossRefPubMed Werba A, Klezl M, Schramm W et al (1993) The level of neuromuscular block needed to suppress diaphragmatic movement during tracheal suction in patients with raised intracranial pressure: a study with vecuronium and atracurium. Anaesthesia 48:301–303CrossRefPubMed
93.
Zurück zum Zitat Yoo YC, Kim NY, Shin S et al (2015) The intraocular pressure under deep versus moderate neuromuscular blockade during low-pressure robot assisted laparoscopic radical prostatectomy in a randomized trial. PLoS ONE 10:e135412CrossRefPubMedPubMedCentral Yoo YC, Kim NY, Shin S et al (2015) The intraocular pressure under deep versus moderate neuromuscular blockade during low-pressure robot assisted laparoscopic radical prostatectomy in a randomized trial. PLoS ONE 10:e135412CrossRefPubMedPubMedCentral
Metadaten
Titel
Vollrelaxation
Nutzen und Risiken
verfasst von
Dr. C. Unterbuchner, DESA
M. Blobner
Publikationsdatum
01.03.2018
Verlag
Springer Medizin
Erschienen in
Die Anaesthesiologie / Ausgabe 3/2018
Print ISSN: 2731-6858
Elektronische ISSN: 2731-6866
DOI
https://doi.org/10.1007/s00101-018-0425-6

Weitere Artikel der Ausgabe 3/2018

Der Anaesthesist 3/2018 Zur Ausgabe

Update AINS

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.